iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067709

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02003061

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000007654.2	ENSMLUT00000007678.2	ENSMLUP00000007010.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-109	366.8	1243	1564

Active Site

Position(s)	Description	Evidence
1532	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1243 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1328
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1329 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1411
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++           +f++e+r +
   Q: 1412 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNQ-----------RFNNEQRLR 1487
           ****************************************************************996...........58******* PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1488 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1564
           **************************************************************************985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAGSAREHLL FVRRRNPQMR YTLSPENLQS LAQGSRPENM ALQRANSDTD LVTSESRSSL 60
TASMYEYTLG RAQNLIIFWD IKEEVDPSDW IGLYHIDENS PANFWDSKNR GVTGTQKGQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGCT CGGCCCGGGA GCACCTGCTC TTCGTGCGGC GGCGGAACCC CCAGATGCGC 60
TACACGCTGA GCCCCGAGAA CCTGCAGAGC CTCGCCCAGG GCTCCCGGCC CGAGAACATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	90.46	0.00e+00	2787.00
IUUC-Apl-003935	Anas platyrhynchos	83.00	0.00e+00	2570.00
IUUC-Aca-004558	Anolis carolinensis	81.92	0.00e+00	2538.00
IUUC-Ame-010893	Astyanax mexicanus	86.78	0.00e+00	1267.00
IUUC-Bta-013093	Bos taurus	94.83	0.00e+00	1540.00
IUUC-Cja-019651	Callithrix jacchus	89.72	0.00e+00	2621.00
IUUC-Cfa-021232	Canis familiaris	97.85	0.00e+00	1589.00
IUUC-Cpo-021770	Cavia porcellus	86.44	0.00e+00	2679.00
IUUC-Csa-023970	Chlorocebus sabaeus	90.20	0.00e+00	2737.00
IUUC-Cho-024512	Choloepus hoffmanni	83.07	0.00e+00	2439.00
IUUC-Csv-026127	Ciona savignyi	70.87	1.00e-150	526.00
IUUC-Dre-028275	Danio rerio	84.04	0.00e+00	1445.00
IUUC-Dno-029963	Dasypus novemcinctus	88.95	0.00e+00	2606.00
IUUC-Dor-030282	Dipodomys ordii	84.52	0.00e+00	1836.00
IUUC-Dme-032217	Drosophila melanogaster	70.52	0.00e+00	631.00
IUUC-Ete-033132	Echinops telfairi	81.46	0.00e+00	1223.00
IUUC-Eca-033978	Equus caballus	90.13	0.00e+00	2746.00
IUUC-Eeu-035278	Erinaceus europaeus	62.97	0.00e+00	1172.00
IUUC-Fca-036157	Felis catus	89.95	0.00e+00	2739.00
IUUC-Fal-037110	Ficedula albicollis	96.35	0.00e+00	1582.00
IUUC-Gmo-039291	Gadus morhua	78.11	0.00e+00	978.00
IUUC-Gga-040821	Gallus gallus	82.97	0.00e+00	2577.00
IUUC-Gac-042456	Gasterosteus aculeatus	63.59	0.00e+00	1832.00
IUUC-Ggo-044862	Gorilla gorilla	90.92	0.00e+00	2657.00
IUUC-Hsa-046219	Homo sapiens	90.96	0.00e+00	2800.00
IUUC-Lch-050526	Latimeria chalumnae	75.70	0.00e+00	2330.00
IUUC-Loc-052648	Lepisosteus oculatus	85.37	0.00e+00	1479.00
IUUC-Laf-054005	Loxodonta africana	89.32	0.00e+00	2742.00
IUUC-Mcc-055314	Macaca mulatta	90.01	0.00e+00	2736.00
IUUC-Meu-056356	Macropus eugenii	65.17	0.00e+00	794.00
IUUC-Mga-060074	Meleagris gallopavo	82.50	0.00e+00	2472.00
IUUC-Mmr-061526	Microcebus murinus	89.95	0.00e+00	2727.00
IUUC-Mdo-063017	Monodelphis domestica	87.06	0.00e+00	2649.00
IUUC-Mmu-064165	Mus musculus	89.11	0.00e+00	2717.00
IUUC-Mpu-065835	Mustela putorius furo	81.61	0.00e+00	1516.00
IUUC-Nle-069308	Nomascus leucogenys	90.96	0.00e+00	2766.00
IUUC-Opr-070330	Ochotona princeps	77.50	0.00e+00	2238.00
IUUC-Ont-071345	Oreochromis niloticus	86.06	0.00e+00	1409.00
IUUC-Ocu-074775	Oryctolagus cuniculus	89.46	0.00e+00	2470.00
IUUC-Ola-087225	Oryzias latipes	63.27	0.00e+00	1787.00
IUUC-Oga-088177	Otolemur garnettii	87.58	0.00e+00	2621.00
IUUC-Oar-089452	Ovis aries	90.20	0.00e+00	2732.00
IUUC-Ptr-090806	Pan troglodytes	90.83	0.00e+00	2786.00
IUUC-Pan-091838	Papio anubis	90.79	0.00e+00	2623.00
IUUC-Psi-094090	Pelodiscus sinensis	83.13	0.00e+00	2558.00
IUUC-Pfo-096520	Poecilia formosa	64.61	0.00e+00	1892.00
IUUC-Pab-098405	Pongo abelii	91.02	0.00e+00	2768.00
IUUC-Pca-100441	Procavia capensis	84.14	0.00e+00	2122.00
IUUC-Pva-102324	Pteropus vampyrus	97.48	0.00e+00	1584.00
IUUC-Rno-105943	Rattus norvegicus	89.29	0.00e+00	2800.00
IUUC-Sha-106985	Sarcophilus harrisii	84.88	0.00e+00	2233.00
IUUC-Sar-113505	Sorex araneus	93.94	0.00e+00	1500.00
IUUC-Ssc-115439	Sus scrofa	87.99	0.00e+00	1815.00
IUUC-Tgu-117078	Taeniopygia guttata	79.39	0.00e+00	2436.00
IUUC-Tru-118671	Takifugu rubripes	79.71	0.00e+00	1411.00
IUUC-Tsy-119498	Tarsius syrichta	98.32	0.00e+00	703.00
IUUC-Tni-120619	Tetraodon nigroviridis	85.88	0.00e+00	1387.00
IUUC-Tbe-127975	Tupaia belangeri	87.80	0.00e+00	2302.00
IUUC-Ttr-128469	Tursiops truncatus	84.88	0.00e+00	2488.00
IUUC-Vpa-130498	Vicugna pacos	81.84	0.00e+00	2313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence