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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045876
UUCD1 version UUC-HoS-00076
Ensembl Protein ID ENSP00000261245.4
UniProt Accession P51948; G3V1U8; Q15817; Q6ICQ7; MAT1_HUMAN
Genbank Protein ID CAA61112.1; CAA63356.1; AAB05248.1; AAN47195.1; EAW80788.1; CAG29332.1; EAW80787.1; AAH00820.1
Protein Name CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36
Genbank Nucleotide ID X87843; X92669; U61835; AY165512; AL132777; CR450336; CH471061; BC000820
Gene Name MNAT1; CAP35; MAT1; RNF66
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000020426.10 ENST00000261245.8 ENSP00000261245.4
ENSG00000020426.10 ENST00000539616.6 ENSP00000446437.2
ENSG00000020426.10 ENST00000554002.5 ENSP00000451379.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16935935
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.12 14.6 6 49
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCle.dfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+ C++  ++++   ++v+ CgH+ +++C+  +     + +++ +CP C
   Q: 6    CPRCKTtKYRNPslkLMVNVCGHTLCESCVDLL-----FVRGAGNCPEC 49
           88887744444333366899*********9655.....699999***99 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
 Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Protein Sequence
(Fasta)
MDDQGCPRCK TTKYRNPSLK LMVNVCGHTL CESCVDLLFV RGAGNCPECG TPLRKSNFRV 60
QLFEDPTVDK EVEIRKKVLK IYNKREEDFP SLREYNDFLE EVEEIVFNLT NNVDLDNTKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045876|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGAAGGGACC GTCTCTGCCA AGCGCCTGTT GGTAGGAACC TGCTTGGTCG CGTCTGAGGG 60
GGCTTGTAGG TGGCTCTGGC TGAAACAGGC GCCTGCGAGA GTCTGTAGGA GGGAAACCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045876|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015877--Cdk-activating_kinase_MAT1_cen
IPR004575--MAT1/Tfb3
IPR003903--UIM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50330--UIM
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF06391--MAT1
PF17121--zf-C3HC4_5
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005675--C:holo TFIIH complex
GO:0005654--C:nucleoplasm
GO:0061575--F:cyclin-dependent protein serine/threonine kinase activator activity
GO:0047485--F:protein N-terminus binding
GO:0008270--F:zinc ion binding
GO:0006370--P:7-methylguanosine mRNA capping
GO:0007512--P:adult heart development
GO:0008283--P:cell proliferation
GO:0006281--P:DNA repair
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0006468--P:protein phosphorylation
GO:0000079--P:regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0051592--P:response to calcium ion
GO:0006363--P:termination of RNA polymerase I transcription
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006361--P:transcription initiation from RNA polymerase I promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0021591--P:ventricular system development
KEGG hsa:4331
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000821 Aegilops tauschii 33.33 8.00e-08 50.40
IUUC-Aml-002414 Ailuropoda melanoleuca 98.38 2.00e-168 584.00
IUUC-Atr-002627 Amborella trichopoda 56.25 7.00e-18 83.60
IUUC-Apl-003312 Anas platyrhynchos 91.40 5.00e-129 453.00
IUUC-Aca-004731 Anolis carolinensis 86.73 8.00e-149 519.00
IUUC-Aly-006244 Arabidopsis lyrata 43.66 7.00e-16 76.60
IUUC-Ath-007136 Arabidopsis thaliana 43.66 7.00e-16 77.00
IUUC-Ago-007788 Ashbya gossypii 30.25 2.00e-28 119.00
IUUC-Acl-008179 Aspergillus clavatus 44.60 7.00e-33 134.00
IUUC-Afl-008465 Aspergillus flavus 45.19 1.00e-32 133.00
IUUC-Afu-009056 Aspergillus fumigatus 44.60 3.00e-33 135.00
IUUC-Ani-009235 Aspergillus nidulans 41.82 3.00e-08 52.40
IUUC-Ang-009677 Aspergillus niger 45.32 2.00e-33 136.00
IUUC-Aor-010017 Aspergillus oryzae 44.60 4.00e-33 135.00
IUUC-Ate-010259 Aspergillus terreus 44.60 1.00e-32 134.00
IUUC-Ame-010934 Astyanax mexicanus 71.34 1.00e-115 409.00
IUUC-Bgr-012074 Blumeria graminis 28.93 1.00e-26 114.00
IUUC-Bta-013329 Bos taurus 97.73 5.00e-167 580.00
IUUC-Bci-013704 Botrytis cinerea 30.00 5.00e-30 125.00
IUUC-Bdi-014672 Brachypodium distachyon 41.43 1.00e-13 69.70
IUUC-Bra-016949 Brassica rapa 46.48 4.00e-16 77.40
IUUC-Cel-018428 Caenorhabditis elegans 32.46 1.00e-44 173.00
IUUC-Cja-019720 Callithrix jacchus 98.38 5.00e-169 586.00
IUUC-Cfa-020319 Canis familiaris 97.41 2.00e-166 578.00
IUUC-Cpo-021652 Cavia porcellus 96.12 8.00e-164 569.00
IUUC-Cre-022749 Chlamydomonas reinhardtii 40.91 1.00e-12 66.20
IUUC-Csa-023560 Chlorocebus sabaeus 100.00 2.00e-171 594.00
IUUC-Cho-025042 Choloepus hoffmanni 58.90 9.00e-79 286.00
IUUC-Cin-025502 Ciona intestinalis 43.26 7.00e-71 260.00
IUUC-Csv-026302 Ciona savignyi 40.95 6.00e-69 254.00
IUUC-Cgl-026541 Colletotrichum gloeosporioides 20.14 4.00e-05 41.60
IUUC-Cne-027055 Cryptococcus neoformans 46.27 1.00e-33 137.00
IUUC-Cme-027128 Cyanidioschyzon merolae 44.07 2.00e-11 62.80
IUUC-Dre-027714 Danio rerio 75.24 2.00e-120 424.00
IUUC-Dno-029232 Dasypus novemcinctus 100.00 6.00e-94 336.00
IUUC-Dor-030996 Dipodomys ordii 70.25 3.00e-90 324.00
IUUC-Dse-031359 Dothistroma septosporum 47.76 2.00e-34 140.00
IUUC-Dme-031992 Drosophila melanogaster 52.90 2.00e-84 305.00
IUUC-Ete-032973 Echinops telfairi 53.40 3.00e-80 291.00
IUUC-Eca-034116 Equus caballus 98.71 5.00e-168 583.00
IUUC-Eeu-035143 Erinaceus europaeus 84.33 5.00e-114 403.00
IUUC-Fca-035960 Felis catus 98.06 2.00e-167 581.00
IUUC-Fal-037039 Ficedula albicollis 89.17 2.00e-112 397.00
IUUC-Fox-037882 Fusarium oxysporum 35.71 3.00e-22 99.40
IUUC-Fso-038318 Fusarium solani 31.44 1.00e-23 103.00
IUUC-Gmo-038905 Gadus morhua 73.29 3.00e-118 418.00
IUUC-Ggr-039857 Gaeumannomyces graminis 34.59 1.00e-14 73.90
IUUC-Gga-041216 Gallus gallus 90.61 3.00e-137 481.00
IUUC-Gac-041987 Gasterosteus aculeatus 74.27 6.00e-123 433.00
IUUC-Gma-044312 Glycine max 51.47 9.00e-18 83.20
IUUC-Ggo-044930 Gorilla gorilla 90.94 5.00e-150 523.00
IUUC-Hvu-047088 Hordeum vulgare 40.00 4.00e-13 67.80
IUUC-Itr-048476 Ictidomys tridecemlineatus 98.08 2.00e-104 371.00
IUUC-Kpa-049202 Komagataella pastoris 31.96 1.00e-27 117.00
IUUC-Lch-049886 Latimeria chalumnae 82.79 6.00e-134 470.00
IUUC-Lpe-051199 Leersia perrieri 44.29 9.00e-15 73.20
IUUC-Loc-052556 Lepisosteus oculatus 76.55 3.00e-111 394.00
IUUC-Lma-053002 Leptosphaeria maculans 43.28 2.00e-29 123.00
IUUC-Laf-054516 Loxodonta africana 97.40 1.00e-165 575.00
IUUC-Mcc-054761 Macaca mulatta 99.63 1.00e-145 508.00
IUUC-Mor-057048 Magnaporthe oryzae 36.76 1.00e-22 100.00
IUUC-Mpo-057598 Magnaporthe poae 37.38 2.00e-12 65.50
IUUC-Mtr-058131 Medicago truncatula 50.75 2.00e-16 79.00
IUUC-Mla-059009 Melampsora laricipopulina 52.55 5.00e-38 150.00
IUUC-Mga-060199 Meleagris gallopavo 88.94 3.00e-70 257.00
IUUC-Mvi-060382 Microbotryum violaceum 43.51 4.00e-32 132.00
IUUC-Mmr-061671 Microcebus murinus 85.11 4.00e-137 480.00
IUUC-Mdo-062228 Monodelphis domestica 96.73 1.00e-162 565.00
IUUC-Mmu-064416 Mus musculus 95.78 9.00e-163 565.00
IUUC-Mac-064807 Musa acuminata 48.44 2.00e-14 72.40
IUUC-Mpu-066455 Mustela putorius furo 97.73 9.00e-167 579.00
IUUC-Mlu-067325 Myotis lucifugus 96.28 9.00e-106 375.00
IUUC-Nfi-068566 Neosartorya fischeri 45.19 1.00e-32 134.00
IUUC-Ncr-068687 Neurospora crassa 39.32 2.00e-23 102.00
IUUC-Nle-069937 Nomascus leucogenys 100.00 2.00e-171 594.00
IUUC-Opr-070321 Ochotona princeps 70.50 6.00e-93 333.00
IUUC-Ont-072636 Oreochromis niloticus 75.90 6.00e-121 426.00
IUUC-Oan-072915 Ornithorhynchus anatinus 84.58 2.00e-104 371.00
IUUC-Ocu-074547 Oryctolagus cuniculus 98.38 2.00e-160 557.00
IUUC-Oba-075269 Oryza barthii 44.29 2.00e-14 72.40
IUUC-Obr-076081 Oryza brachyantha 42.86 1.00e-14 73.20
IUUC-Ogl-077011 Oryza glaberrima 44.29 2.00e-14 72.40
IUUC-Ogu-078667 Oryza glumaepatula 44.29 2.00e-14 72.40
IUUC-Oin-079153 Oryza indica 44.29 2.00e-14 72.40
IUUC-Olo-080344 Oryza longistaminata 44.83 5.00e-11 61.20
IUUC-Ome-081805 Oryza meridionalis 41.43 1.00e-13 70.50
IUUC-Oni-082783 Oryza nivara 41.43 2.00e-13 68.60
IUUC-Opu-083247 Oryza punctata 42.86 3.00e-14 71.60
IUUC-Oru-085262 Oryza rufipogon 44.29 2.00e-14 72.40
IUUC-Osa-086250 Oryza sativa 44.29 1.00e-14 72.80
IUUC-Ola-086780 Oryzias latipes 74.92 1.00e-123 435.00
IUUC-Olu-087653 Ostreococcus lucimarinus 39.39 9.00e-12 63.20
IUUC-Oga-088012 Otolemur garnettii 85.53 4.00e-138 483.00
IUUC-Oar-090274 Ovis aries 90.29 3.00e-147 514.00
IUUC-Ptr-090780 Pan troglodytes 100.00 2.00e-171 594.00
IUUC-Pan-091815 Papio anubis 79.57 5.00e-85 306.00
IUUC-Psi-093883 Pelodiscus sinensis 89.00 4.00e-149 520.00
IUUC-Pma-094717 Petromyzon marinus 56.49 9.00e-54 203.00
IUUC-Pno-094958 Phaeosphaeria nodorum 44.53 8.00e-32 130.00
IUUC-Ppa-095445 Physcomitrella patens 56.67 2.00e-16 79.00
IUUC-Pfo-096051 Poecilia formosa 71.79 1.00e-98 352.00
IUUC-Pab-097609 Pongo abelii 94.77 1.00e-144 505.00
IUUC-Pop-099460 Populus trichocarpa 52.11 9.00e-19 86.70
IUUC-Pca-101094 Procavia capensis 97.13 1.00e-144 505.00
IUUC-Ppe-101481 Prunus persica 51.47 4.00e-17 81.30
IUUC-Pva-103219 Pteropus vampyrus 96.76 5.00e-154 536.00
IUUC-Pgr-103557 Puccinia graminis 48.91 3.00e-36 146.00
IUUC-Ptt-103719 Puccinia triticina 48.91 6.00e-37 148.00
IUUC-Pte-104301 Pyrenophora teres 42.34 2.00e-27 116.00
IUUC-Pyt-104486 Pyrenophora triticirepentis 45.00 9.00e-28 117.00
IUUC-Rno-105846 Rattus norvegicus 96.43 8.00e-164 569.00
IUUC-Sce-106405 Saccharomyces cerevisiae 45.19 6.00e-29 121.00
IUUC-Sha-107594 Sarcophilus harrisii 92.86 1.00e-72 265.00
IUUC-Sja-107951 Schizosaccharomyces japonicus 33.55 1.00e-35 143.00
IUUC-Spo-108137 Schizosaccharomyces pombe 44.68 2.00e-33 135.00
IUUC-Ssl-108503 Sclerotinia sclerotiorum 28.06 2.00e-32 132.00
IUUC-Smo-109621 Selaginella moellendorffii 43.06 2.00e-16 78.20
IUUC-Sit-110672 Setaria italica 47.14 2.00e-15 75.90
IUUC-Sly-111744 Solanum lycopersicum 57.81 2.00e-18 85.50
IUUC-Stu-112343 Solanum tuberosum 56.25 1.00e-17 83.20
IUUC-Sar-113298 Sorex araneus 92.86 1.00e-129 455.00
IUUC-Sbi-113918 Sorghum bicolor 42.86 2.00e-14 72.00
IUUC-Sre-114991 Sporisorium reilianum 47.01 6.00e-32 131.00
IUUC-Ssc-116152 Sus scrofa 98.51 7.00e-100 355.00
IUUC-Tgu-116452 Taeniopygia guttata 89.97 6.00e-148 516.00
IUUC-Tru-118621 Takifugu rubripes 73.23 3.00e-118 417.00
IUUC-Tsy-119500 Tarsius syrichta 84.79 1.00e-137 482.00
IUUC-Tni-120454 Tetraodon nigroviridis 61.95 5.00e-85 307.00
IUUC-Tca-121192 Theobroma cacao 46.48 5.00e-17 80.90
IUUC-Tre-122011 Trichoderma reesei 33.67 6.00e-24 105.00
IUUC-Tvi-122317 Trichoderma virens 29.78 6.00e-27 114.00
IUUC-Tae-123854 Triticum aestivum 41.43 4.00e-14 71.20
IUUC-Tur-126556 Triticum urartu 41.43 8.00e-14 70.10
IUUC-Tme-127135 Tuber melanosporum 49.64 6.00e-31 128.00
IUUC-Tbe-127287 Tupaia belangeri 96.77 2.00e-144 504.00
IUUC-Ttr-128864 Tursiops truncatus 98.06 8.00e-167 579.00
IUUC-Uma-129539 Ustilago maydis 50.41 1.00e-34 140.00
IUUC-Vda-129713 Verticillium dahliae 43.64 2.00e-18 86.70
IUUC-Vpa-130462 Vicugna pacos 93.20 2.00e-154 538.00
IUUC-Vvi-130988 Vitis vinifera 50.00 1.00e-16 79.30
IUUC-Xtr-131830 Xenopus tropicalis 81.20 8.00e-104 369.00
IUUC-Xma-133952 Xiphophorus maculatus 71.43 1.00e-99 355.00
IUUC-Yli-134433 Yarrowia lipolytica 31.48 6.00e-32 131.00
IUUC-Zma-134867 Zea mays 41.43 4.00e-14 70.90
Created Date 25-Jun-2017

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