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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064189
UUCD1 version UUC-MuM-00578
Ensembl Protein ID ENSMUSP00000045998.4
UniProt Accession Q80U95; Q0VB95; Q8BQZ6; Q8C7W6; Q8CDJ1; Q8VDL5; UBE3C_MOUSE
Genbank Protein ID BAC65469.1; BAC26709.1; BAC32585.1; BAC33557.1; AAH21525.1; AAI20732.1; AAI37627.1
Protein Name Ubiquitin-protein ligase E3C; HECT-type ubiquitin transferase E3C
Genbank Nucleotide ID AK122187; AK029973; AK046056; AK049125; BC021525; BC120731; BC137626
Gene Name Ube3c; Kiaa0010; Kiaa10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039000.8 ENSMUST00000049453.8 ENSMUSP00000045998.4
ENSMUSG00000039000.8 ENSMUST00000199032.1 ENSMUSP00000142474.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.30e-103 347.3 746 1083
Active Site
Position(s) Description Evidence
1051 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 746  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 831
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+y++l ++k++ e+d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 832  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYRNLLFLKSY-EEDVEELGLNFTVV--NNDLGEAQVVELKFGGKDIPVTGAN 915
           ******************9666889********************.67999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i+ ++ afr+G+ +v++le+l++F+++e+++li+G    +++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 916  RIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAqVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEG 1002
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  +  l++kLlyAie ++gFels
   Q: 1003 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS 1083
           ****************************88.*****99999**************************************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
 E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Protein Sequence
(Fasta)
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAV IIQSFIRGYR 60
DRKQQYFIQR SAFDQCTDSA QPGGTFCLAD GPNLTLLVRQ LLFFYKQSED SKRLIWLYQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064189|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCATCTTGG TACCTACGGC AGCGCGGTGC AGGCGCGAGT CGGGGCGTCC CTCGCTTGAC 60
GGTGGCGCGC TGTGGATAAA TAAGCAGCGG GGACAGGCCG GCCTCCAGCG TCGCCGCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064189|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
PROSITE

PS50237--HECT
PS50096--IQ
Pfam

PF00632--HECT
SMART

SM00119--HECTc
SM00015--IQ
Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
KEGG mmu:100763
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001355 Ailuropoda melanoleuca 90.68 0.00e+00 1909.00
IUUC-Apl-003731 Anas platyrhynchos 88.57 0.00e+00 1897.00
IUUC-Aca-005248 Anolis carolinensis 87.18 0.00e+00 1905.00
IUUC-Aly-005768 Arabidopsis lyrata 35.44 1.00e-107 384.00
IUUC-Ath-006576 Arabidopsis thaliana 29.89 6.00e-115 409.00
IUUC-Ago-007748 Ashbya gossypii 41.84 3.00e-76 280.00
IUUC-Acl-008158 Aspergillus clavatus 37.95 2.00e-75 278.00
IUUC-Afl-008398 Aspergillus flavus 33.85 3.00e-77 283.00
IUUC-Afu-008937 Aspergillus fumigatus 34.71 1.00e-79 291.00
IUUC-Ani-009252 Aspergillus nidulans 37.95 2.00e-79 291.00
IUUC-Ang-009773 Aspergillus niger 34.08 3.00e-77 283.00
IUUC-Aor-009940 Aspergillus oryzae 33.85 3.00e-77 283.00
IUUC-Ate-010395 Aspergillus terreus 39.02 4.00e-76 280.00
IUUC-Ame-010769 Astyanax mexicanus 62.83 0.00e+00 1039.00
IUUC-Bgr-012269 Blumeria graminis 37.61 1.00e-73 270.00
IUUC-Bta-012841 Bos taurus 89.95 0.00e+00 1917.00
IUUC-Bci-013743 Botrytis cinerea 29.64 2.00e-83 304.00
IUUC-Bdi-014123 Brachypodium distachyon 46.57 4.00e-101 363.00
IUUC-Bol-015390 Brassica oleracea 34.62 1.00e-99 358.00
IUUC-Bra-016853 Brassica rapa 35.54 1.00e-106 381.00
IUUC-Cel-018638 Caenorhabditis elegans 39.86 9.00e-90 325.00
IUUC-Cja-019743 Callithrix jacchus 90.80 0.00e+00 1915.00
IUUC-Cfa-021031 Canis familiaris 91.82 0.00e+00 1955.00
IUUC-Cpo-022401 Cavia porcellus 92.71 0.00e+00 1968.00
IUUC-Cre-022725 Chlamydomonas reinhardtii 44.76 9.00e-86 310.00
IUUC-Csa-024107 Chlorocebus sabaeus 93.07 0.00e+00 1985.00
IUUC-Cho-024750 Choloepus hoffmanni 82.29 0.00e+00 794.00
IUUC-Cin-025432 Ciona intestinalis 44.66 2.00e-97 349.00
IUUC-Cgl-026559 Colletotrichum gloeosporioides 34.15 3.00e-87 317.00
IUUC-Cne-026841 Cryptococcus neoformans 36.48 1.00e-94 341.00
IUUC-Cme-027265 Cyanidioschyzon merolae 46.62 2.00e-102 367.00
IUUC-Dre-028196 Danio rerio 77.86 0.00e+00 1600.00
IUUC-Dno-029024 Dasypus novemcinctus 92.53 0.00e+00 1977.00
IUUC-Dor-030483 Dipodomys ordii 92.17 0.00e+00 689.00
IUUC-Dse-031416 Dothistroma septosporum 34.08 2.00e-78 288.00
IUUC-Dme-031946 Drosophila melanogaster 36.85 0.00e+00 672.00
IUUC-Ete-032240 Echinops telfairi 81.45 3.00e-174 605.00
IUUC-Eca-033828 Equus caballus 92.09 0.00e+00 1932.00
IUUC-Eeu-034604 Erinaceus europaeus 85.77 6.00e-127 448.00
IUUC-Fca-035907 Felis catus 90.22 0.00e+00 1956.00
IUUC-Fal-037389 Ficedula albicollis 89.02 0.00e+00 1928.00
IUUC-Fox-037788 Fusarium oxysporum 37.61 6.00e-93 335.00
IUUC-Fso-038088 Fusarium solani 36.20 1.00e-89 325.00
IUUC-Gmo-039254 Gadus morhua 66.67 0.00e+00 1226.00
IUUC-Ggr-039941 Gaeumannomyces graminis 33.74 8.00e-83 302.00
IUUC-Gga-040310 Gallus gallus 88.19 0.00e+00 1913.00
IUUC-Gac-042054 Gasterosteus aculeatus 69.70 0.00e+00 1303.00
IUUC-Gma-042836 Glycine max 30.25 9.00e-103 368.00
IUUC-Ggo-045031 Gorilla gorilla 93.44 0.00e+00 1993.00
IUUC-Hsa-045880 Homo sapiens 93.35 0.00e+00 1992.00
IUUC-Itr-048555 Ictidomys tridecemlineatus 88.15 0.00e+00 706.00
IUUC-Kpa-049307 Komagataella pastoris 36.52 1.00e-64 241.00
IUUC-Lch-050403 Latimeria chalumnae 81.35 0.00e+00 1680.00
IUUC-Lpe-051428 Leersia perrieri 46.65 2.00e-95 344.00
IUUC-Loc-052218 Lepisosteus oculatus 80.66 0.00e+00 1692.00
IUUC-Lma-053096 Leptosphaeria maculans 38.44 3.00e-79 290.00
IUUC-Laf-054162 Loxodonta africana 87.07 0.00e+00 1658.00
IUUC-Mcc-055127 Macaca mulatta 93.17 0.00e+00 1988.00
IUUC-Meu-056187 Macropus eugenii 82.17 2.00e-104 374.00
IUUC-Mor-057021 Magnaporthe oryzae 34.49 1.00e-78 288.00
IUUC-Mpo-057570 Magnaporthe poae 36.24 2.00e-75 278.00
IUUC-Mtr-058154 Medicago truncatula 30.02 5.00e-104 372.00
IUUC-Mla-059124 Melampsora laricipopulina 48.03 9.00e-101 360.00
IUUC-Mga-059581 Meleagris gallopavo 88.50 0.00e+00 1905.00
IUUC-Mvi-060445 Microbotryum violaceum 37.38 1.00e-102 368.00
IUUC-Mmr-061360 Microcebus murinus 88.55 0.00e+00 1821.00
IUUC-Mdo-062194 Monodelphis domestica 85.82 0.00e+00 1909.00
IUUC-Mac-065275 Musa acuminata 49.63 2.00e-108 387.00
IUUC-Mpu-066439 Mustela putorius furo 90.73 0.00e+00 1904.00
IUUC-Mlu-068228 Myotis lucifugus 87.72 0.00e+00 1880.00
IUUC-Nfi-068280 Neosartorya fischeri 38.43 4.00e-78 286.00
IUUC-Ncr-068869 Neurospora crassa 35.61 7.00e-82 299.00
IUUC-Nle-069687 Nomascus leucogenys 92.93 0.00e+00 1935.00
IUUC-Opr-070592 Ochotona princeps 75.00 5.00e-122 432.00
IUUC-Ont-071836 Oreochromis niloticus 78.60 0.00e+00 1645.00
IUUC-Oan-072800 Ornithorhynchus anatinus 88.84 0.00e+00 1922.00
IUUC-Ocu-074587 Oryctolagus cuniculus 93.81 0.00e+00 2007.00
IUUC-Ola-087209 Oryzias latipes 77.84 0.00e+00 1620.00
IUUC-Olu-087699 Ostreococcus lucimarinus 42.86 1.00e-85 310.00
IUUC-Oga-088776 Otolemur garnettii 88.09 0.00e+00 1800.00
IUUC-Oar-089441 Ovis aries 89.50 0.00e+00 1900.00
IUUC-Ptr-091273 Pan troglodytes 93.26 0.00e+00 1989.00
IUUC-Pan-091981 Papio anubis 93.26 0.00e+00 1987.00
IUUC-Psi-093203 Pelodiscus sinensis 87.15 0.00e+00 1652.00
IUUC-Pma-094738 Petromyzon marinus 65.05 0.00e+00 1330.00
IUUC-Pno-095132 Phaeosphaeria nodorum 29.38 3.00e-59 223.00
IUUC-Ppa-095682 Physcomitrella patens 35.59 1.00e-112 401.00
IUUC-Pfo-097511 Poecilia formosa 78.78 0.00e+00 1655.00
IUUC-Pab-098634 Pongo abelii 90.22 0.00e+00 1907.00
IUUC-Pop-098928 Populus trichocarpa 34.94 3.00e-98 353.00
IUUC-Pca-100987 Procavia capensis 84.93 0.00e+00 855.00
IUUC-Ppe-102040 Prunus persica 30.09 4.00e-97 349.00
IUUC-Pva-103034 Pteropus vampyrus 86.63 0.00e+00 1794.00
IUUC-Pgr-103513 Puccinia graminis 39.18 8.00e-105 375.00
IUUC-Ptt-103967 Puccinia triticina 41.32 5.00e-93 335.00
IUUC-Pte-104105 Pyrenophora teres 34.21 1.00e-79 291.00
IUUC-Pyt-104449 Pyrenophora triticirepentis 34.21 3.00e-79 290.00
IUUC-Rno-105380 Rattus norvegicus 97.09 0.00e+00 1799.00
IUUC-Sce-106446 Saccharomyces cerevisiae 40.29 3.00e-67 250.00
IUUC-Sha-107108 Sarcophilus harrisii 82.69 0.00e+00 1754.00
IUUC-Sja-107889 Schizosaccharomyces japonicus 43.39 7.00e-93 335.00
IUUC-Spo-108097 Schizosaccharomyces pombe 43.87 1.00e-92 334.00
IUUC-Ssl-108520 Sclerotinia sclerotiorum 29.04 1.00e-80 295.00
IUUC-Sit-110457 Setaria italica 48.53 3.00e-98 353.00
IUUC-Sar-113687 Sorex araneus 80.76 0.00e+00 902.00
IUUC-Sre-115038 Sporisorium reilianum 44.47 1.00e-96 348.00
IUUC-Ssc-116168 Sus scrofa 81.34 0.00e+00 783.00
IUUC-Tgu-116729 Taeniopygia guttata 88.76 0.00e+00 1913.00
IUUC-Tru-118068 Takifugu rubripes 77.01 0.00e+00 1607.00
IUUC-Tsy-118942 Tarsius syrichta 93.70 0.00e+00 720.00
IUUC-Tni-120732 Tetraodon nigroviridis 76.54 0.00e+00 1557.00
IUUC-Tre-121892 Trichoderma reesei 37.66 2.00e-88 320.00
IUUC-Tvi-122354 Trichoderma virens 36.04 1.00e-89 324.00
IUUC-Tme-127102 Tuber melanosporum 35.69 6.00e-91 329.00
IUUC-Tbe-127351 Tupaia belangeri 80.36 0.00e+00 1518.00
IUUC-Ttr-129061 Tursiops truncatus 88.10 0.00e+00 1857.00
IUUC-Uma-129343 Ustilago maydis 44.47 2.00e-97 350.00
IUUC-Vda-129748 Verticillium dahliae 38.38 5.00e-80 292.00
IUUC-Vvi-131234 Vitis vinifera 29.99 1.00e-104 375.00
IUUC-Xtr-132094 Xenopus tropicalis 84.35 0.00e+00 1776.00
IUUC-Xma-133923 Xiphophorus maculatus 78.87 0.00e+00 1656.00
Created Date 25-Jun-2017

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