iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098634

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01364086

Gene Name

UBE3C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000018227.1	ENSPPYT00000021241.1	ENSPPYP00000020431.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-86	291.1	746	1080

Active Site

Position(s)	Description	Evidence
1048	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 746  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 831
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e+d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 832  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EDDVEELGLNFTV--VNNDLGEAQVVELKFGGKDIPVTSAN 915
           ******************9666889********************.6788887666665..5889********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketky.kggytedspaiqwFwevle 254
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i+    k+   +  ggy++d+++i+ Fw+v e
   Q: 916  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAqVPISGIXXKACVHFaIGGYSKDHRVIKVFWRV-E 1001
           ****************************************************5566666666666887899************95.* PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f +ee++++++ +T++    ++ f+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1002 GFGKEEKRKLMKNMTSCT---HAVFQELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1080
           ******************...5569****88.*****99999**************************************985 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQYSIQR SAFDRCATLS QSGGAFPIAN GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCAGCT TCGAAGGTGA CTTCAAGACG CGGCCCAAGG TGTCCCTTGG CGGCGCGAGC 60
AGGAAGGTGA GGGCCGGGCT GGCGGGGCGC CCTCGGCTCG GGGCCTGCTC GGCCAGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	90.78	0.00e+00	1878.00
IUUC-Apl-003731	Anas platyrhynchos	87.75	0.00e+00	1855.00
IUUC-Aca-005248	Anolis carolinensis	86.35	0.00e+00	1844.00
IUUC-Acl-008158	Aspergillus clavatus	35.18	5.00e-64	239.00
IUUC-Afl-008398	Aspergillus flavus	31.79	8.00e-65	242.00
IUUC-Afu-008937	Aspergillus fumigatus	35.67	2.00e-66	248.00
IUUC-Ang-009773	Aspergillus niger	31.79	2.00e-66	248.00
IUUC-Aor-009940	Aspergillus oryzae	31.79	9.00e-65	242.00
IUUC-Ate-010395	Aspergillus terreus	34.75	4.00e-64	240.00
IUUC-Ame-010769	Astyanax mexicanus	59.81	0.00e+00	971.00
IUUC-Bgr-012269	Blumeria graminis	35.15	8.00e-65	240.00
IUUC-Bta-012841	Bos taurus	90.06	0.00e+00	1889.00
IUUC-Bci-013743	Botrytis cinerea	29.10	2.00e-71	264.00
IUUC-Cel-018638	Caenorhabditis elegans	38.01	2.00e-82	301.00
IUUC-Cja-019743	Callithrix jacchus	93.69	0.00e+00	1922.00
IUUC-Cfa-021031	Canis familiaris	92.19	0.00e+00	1929.00
IUUC-Cpo-022401	Cavia porcellus	90.31	0.00e+00	1899.00
IUUC-Csa-024107	Chlorocebus sabaeus	96.59	0.00e+00	2000.00
IUUC-Cho-024750	Choloepus hoffmanni	77.34	0.00e+00	734.00
IUUC-Cin-025432	Ciona intestinalis	43.90	6.00e-92	330.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	31.83	6.00e-75	276.00
IUUC-Cne-026841	Cryptococcus neoformans	31.52	8.00e-80	292.00
IUUC-Cme-027265	Cyanidioschyzon merolae	43.88	1.00e-91	330.00
IUUC-Dre-028196	Danio rerio	74.17	0.00e+00	1521.00
IUUC-Dno-029024	Dasypus novemcinctus	93.09	0.00e+00	1956.00
IUUC-Dor-030483	Dipodomys ordii	90.77	0.00e+00	681.00
IUUC-Dme-031946	Drosophila melanogaster	34.63	3.00e-173	602.00
IUUC-Ete-032240	Echinops telfairi	83.86	2.00e-174	606.00
IUUC-Eca-033828	Equus caballus	92.38	0.00e+00	1912.00
IUUC-Eeu-034604	Erinaceus europaeus	85.38	4.00e-127	449.00
IUUC-Fca-035907	Felis catus	91.34	0.00e+00	1930.00
IUUC-Fal-037389	Ficedula albicollis	87.93	0.00e+00	1882.00
IUUC-Fox-037788	Fusarium oxysporum	34.54	2.00e-78	287.00
IUUC-Fso-038088	Fusarium solani	33.58	2.00e-76	281.00
IUUC-Gmo-039254	Gadus morhua	68.46	0.00e+00	1224.00
IUUC-Gga-040310	Gallus gallus	87.65	0.00e+00	1873.00
IUUC-Gac-042054	Gasterosteus aculeatus	68.91	0.00e+00	1288.00
IUUC-Ggo-045031	Gorilla gorilla	96.77	0.00e+00	2004.00
IUUC-Hsa-045880	Homo sapiens	96.86	0.00e+00	2005.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	90.76	0.00e+00	718.00
IUUC-Lch-050403	Latimeria chalumnae	79.71	0.00e+00	1608.00
IUUC-Loc-052218	Lepisosteus oculatus	78.18	0.00e+00	1623.00
IUUC-Laf-054162	Loxodonta africana	90.65	0.00e+00	1675.00
IUUC-Mcc-055127	Macaca mulatta	96.49	0.00e+00	1996.00
IUUC-Meu-056187	Macropus eugenii	82.17	3.00e-105	376.00
IUUC-Mor-057021	Magnaporthe oryzae	32.75	3.00e-66	247.00
IUUC-Mla-059124	Melampsora laricipopulina	44.61	2.00e-90	325.00
IUUC-Mga-059581	Meleagris gallopavo	87.67	0.00e+00	1860.00
IUUC-Mvi-060445	Microbotryum violaceum	35.68	3.00e-91	330.00
IUUC-Mmr-061360	Microcebus murinus	89.60	0.00e+00	1821.00
IUUC-Mdo-062194	Monodelphis domestica	84.68	0.00e+00	1863.00
IUUC-Mmu-064189	Mus musculus	90.22	0.00e+00	1932.00
IUUC-Mpu-066439	Mustela putorius furo	90.18	0.00e+00	1858.00
IUUC-Mlu-068228	Myotis lucifugus	86.53	0.00e+00	1834.00
IUUC-Nfi-068280	Neosartorya fischeri	35.67	1.00e-66	248.00
IUUC-Nle-069687	Nomascus leucogenys	96.14	0.00e+00	1944.00
IUUC-Opr-070592	Ochotona princeps	78.90	2.00e-128	453.00
IUUC-Ont-071836	Oreochromis niloticus	75.18	0.00e+00	1574.00
IUUC-Oan-072800	Ornithorhynchus anatinus	88.48	0.00e+00	1878.00
IUUC-Ocu-074587	Oryctolagus cuniculus	94.46	0.00e+00	1978.00
IUUC-Ola-087209	Oryzias latipes	75.28	0.00e+00	1553.00
IUUC-Oga-088776	Otolemur garnettii	88.01	0.00e+00	1767.00
IUUC-Oar-089441	Ovis aries	88.96	0.00e+00	1866.00
IUUC-Ptr-091273	Pan troglodytes	96.77	0.00e+00	2003.00
IUUC-Pan-091981	Papio anubis	96.59	0.00e+00	2001.00
IUUC-Psi-093203	Pelodiscus sinensis	88.70	0.00e+00	1671.00
IUUC-Pma-094738	Petromyzon marinus	62.03	0.00e+00	1248.00
IUUC-Pfo-097511	Poecilia formosa	75.09	0.00e+00	1584.00
IUUC-Pca-100987	Procavia capensis	91.89	0.00e+00	784.00
IUUC-Pva-103034	Pteropus vampyrus	86.27	0.00e+00	1752.00
IUUC-Pgr-103513	Puccinia graminis	35.31	2.00e-94	340.00
IUUC-Ptt-103967	Puccinia triticina	38.25	2.00e-81	297.00
IUUC-Rno-105380	Rattus norvegicus	92.00	0.00e+00	1733.00
IUUC-Sce-106446	Saccharomyces cerevisiae	37.08	5.00e-60	226.00
IUUC-Sha-107108	Sarcophilus harrisii	81.78	0.00e+00	1716.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	29.01	5.00e-70	259.00
IUUC-Sar-113687	Sorex araneus	81.96	0.00e+00	912.00
IUUC-Sre-115038	Sporisorium reilianum	41.18	7.00e-87	315.00
IUUC-Ssc-116168	Sus scrofa	87.21	0.00e+00	804.00
IUUC-Tgu-116729	Taeniopygia guttata	87.75	0.00e+00	1875.00
IUUC-Tru-118068	Takifugu rubripes	74.35	0.00e+00	1544.00
IUUC-Tsy-118942	Tarsius syrichta	96.13	0.00e+00	717.00
IUUC-Tni-120732	Tetraodon nigroviridis	73.25	0.00e+00	1484.00
IUUC-Tbe-127351	Tupaia belangeri	80.52	0.00e+00	1487.00
IUUC-Ttr-129061	Tursiops truncatus	87.74	0.00e+00	1830.00
IUUC-Uma-129343	Ustilago maydis	41.67	3.00e-88	320.00
IUUC-Vda-129748	Verticillium dahliae	35.09	1.00e-66	248.00
IUUC-Xtr-132094	Xenopus tropicalis	83.16	0.00e+00	1723.00
IUUC-Xma-133923	Xiphophorus maculatus	75.37	0.00e+00	1587.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence