iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000060006.6	ENSDART00000146576.2	ENSDARP00000117300.1
ENSDARG00000060006.6	ENSDART00000084061.5	ENSDARP00000078496.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-135	452.3	677	1008

Active Site

Position(s)	Description	Evidence
978	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           +++lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+ll
   Q: 677  PDSLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 763
           6789*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++e+++g+t++++Lkp+G+++ Vtn+Nk+eY++
   Q: 764  DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYID 845
           *************************************99...6666..7************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r+ +++++q++af eGf+e+ip++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r 
   Q: 846  LVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRI 932
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++LqFvTg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP Y++ e l+ekLl+A+e+++gFe
   Q: 933  RLLQFVTGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGFE 1008
           ***************************************************************************8 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MATNFEPIYG LSEDENESRI LRVKVIAGID LAKKDIIGAS DPYVKLSLYV ADENRELALV 60
QTKTIKKTLN PKWNEEFYFR VCPQNHRLLF EVFDENRLAH IGLDRPKNGH FNNGQTRDDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGAGGAA GTGAATGATT CGCGTTTGCA CTTGACGAGG GGAAATCATA TTGTTGGGGG 60
AAATTAAGCG TGTATCCACC TAAATTCCGC CGTTAAATGA GATTAAACTG GCGGACGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	78.21	0.00e+00	1415.00
IUUC-Apl-003893	Anas platyrhynchos	78.39	0.00e+00	1453.00
IUUC-Aca-004744	Anolis carolinensis	75.73	0.00e+00	1405.00
IUUC-Acl-008273	Aspergillus clavatus	47.98	1.00e-159	557.00
IUUC-Afl-008713	Aspergillus flavus	48.53	1.00e-158	553.00
IUUC-Afu-009103	Aspergillus fumigatus	48.05	4.00e-159	555.00
IUUC-Ani-009259	Aspergillus nidulans	47.88	5.00e-158	551.00
IUUC-Ang-009738	Aspergillus niger	54.12	5.00e-151	528.00
IUUC-Aor-010053	Aspergillus oryzae	57.38	3.00e-100	358.00
IUUC-Ate-010529	Aspergillus terreus	48.05	4.00e-160	558.00
IUUC-Ame-010810	Astyanax mexicanus	91.85	0.00e+00	1095.00
IUUC-Bgr-012148	Blumeria graminis	46.74	2.00e-152	533.00
IUUC-Bta-012679	Bos taurus	78.98	0.00e+00	1327.00
IUUC-Bci-013785	Botrytis cinerea	46.49	2.00e-153	536.00
IUUC-Cel-018564	Caenorhabditis elegans	50.73	7.00e-180	624.00
IUUC-Cja-018732	Callithrix jacchus	78.92	0.00e+00	1508.00
IUUC-Cfa-021226	Canis familiaris	79.90	0.00e+00	1496.00
IUUC-Cpo-021671	Cavia porcellus	78.00	0.00e+00	1464.00
IUUC-Csa-023344	Chlorocebus sabaeus	77.73	0.00e+00	1486.00
IUUC-Cho-024832	Choloepus hoffmanni	94.89	0.00e+00	719.00
IUUC-Cin-025157	Ciona intestinalis	61.39	0.00e+00	773.00
IUUC-Csv-026098	Ciona savignyi	67.49	0.00e+00	636.00
IUUC-Dno-029466	Dasypus novemcinctus	79.21	0.00e+00	1506.00
IUUC-Dor-030138	Dipodomys ordii	76.39	0.00e+00	1371.00
IUUC-Dme-032166	Drosophila melanogaster	68.13	0.00e+00	714.00
IUUC-Ete-033145	Echinops telfairi	73.89	0.00e+00	1077.00
IUUC-Eca-033445	Equus caballus	79.76	0.00e+00	1316.00
IUUC-Eeu-035247	Erinaceus europaeus	78.45	0.00e+00	1183.00
IUUC-Fca-035489	Felis catus	77.02	0.00e+00	1270.00
IUUC-Fal-037604	Ficedula albicollis	76.68	0.00e+00	1475.00
IUUC-Fox-037774	Fusarium oxysporum	46.09	2.00e-152	533.00
IUUC-Gmo-039674	Gadus morhua	81.30	0.00e+00	1500.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.42	1.00e-152	533.00
IUUC-Gga-040703	Gallus gallus	79.21	0.00e+00	1504.00
IUUC-Gac-042020	Gasterosteus aculeatus	84.35	0.00e+00	1568.00
IUUC-Ggo-045332	Gorilla gorilla	77.99	0.00e+00	1427.00
IUUC-Hsa-045968	Homo sapiens	79.01	0.00e+00	1500.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	65.57	0.00e+00	817.00
IUUC-Lch-050443	Latimeria chalumnae	79.26	0.00e+00	1328.00
IUUC-Loc-052662	Lepisosteus oculatus	85.05	0.00e+00	1547.00
IUUC-Laf-053850	Loxodonta africana	78.70	0.00e+00	1477.00
IUUC-Mcc-055821	Macaca mulatta	79.26	0.00e+00	1476.00
IUUC-Meu-056897	Macropus eugenii	85.02	8.00e-151	528.00
IUUC-Mor-057097	Magnaporthe oryzae	44.36	6.00e-153	535.00
IUUC-Mpo-057442	Magnaporthe poae	51.44	4.00e-144	505.00
IUUC-Mga-059264	Meleagris gallopavo	63.08	0.00e+00	898.00
IUUC-Mvi-060395	Microbotryum violaceum	54.73	1.00e-152	534.00
IUUC-Mmr-060798	Microcebus murinus	75.92	0.00e+00	1380.00
IUUC-Mdo-062173	Monodelphis domestica	77.95	0.00e+00	1508.00
IUUC-Mmu-064136	Mus musculus	78.33	0.00e+00	1492.00
IUUC-Mpu-066765	Mustela putorius furo	79.76	0.00e+00	1476.00
IUUC-Mlu-067565	Myotis lucifugus	79.18	0.00e+00	1327.00
IUUC-Nfi-068427	Neosartorya fischeri	48.05	2.00e-159	556.00
IUUC-Ncr-068918	Neurospora crassa	46.33	2.00e-152	533.00
IUUC-Nle-069070	Nomascus leucogenys	76.35	0.00e+00	1437.00
IUUC-Opr-071044	Ochotona princeps	86.03	0.00e+00	1078.00
IUUC-Ont-072044	Oreochromis niloticus	85.34	0.00e+00	1634.00
IUUC-Oan-073032	Ornithorhynchus anatinus	75.14	0.00e+00	1199.00
IUUC-Ocu-074160	Oryctolagus cuniculus	77.90	0.00e+00	1450.00
IUUC-Ola-087467	Oryzias latipes	83.76	0.00e+00	1566.00
IUUC-Oga-088460	Otolemur garnettii	78.44	0.00e+00	1308.00
IUUC-Oar-090198	Ovis aries	79.10	0.00e+00	1466.00
IUUC-Ptr-090939	Pan troglodytes	79.01	0.00e+00	1500.00
IUUC-Pan-092284	Papio anubis	79.21	0.00e+00	1502.00
IUUC-Psi-093645	Pelodiscus sinensis	78.49	0.00e+00	1498.00
IUUC-Pma-094364	Petromyzon marinus	81.67	0.00e+00	839.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.98	9.00e-158	551.00
IUUC-Pfo-096768	Poecilia formosa	95.02	0.00e+00	991.00
IUUC-Pab-098088	Pongo abelii	79.18	0.00e+00	1485.00
IUUC-Pca-100714	Procavia capensis	70.63	0.00e+00	979.00
IUUC-Pva-102354	Pteropus vampyrus	78.23	0.00e+00	1417.00
IUUC-Pgr-103620	Puccinia graminis	53.11	7.00e-147	514.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-123	437.00
IUUC-Pte-104016	Pyrenophora teres	52.99	1.00e-150	527.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	52.99	1.00e-150	527.00
IUUC-Rno-105318	Rattus norvegicus	77.40	0.00e+00	1451.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.29	7.00e-162	564.00
IUUC-Sha-107482	Sarcophilus harrisii	79.89	0.00e+00	1348.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.98	9.00e-155	540.00
IUUC-Stu-112582	Solanum tuberosum	35.54	2.00e-53	204.00
IUUC-Ssc-115950	Sus scrofa	63.83	0.00e+00	1059.00
IUUC-Tgu-117130	Taeniopygia guttata	78.80	0.00e+00	1487.00
IUUC-Tru-118610	Takifugu rubripes	84.61	0.00e+00	1603.00
IUUC-Tsy-119492	Tarsius syrichta	74.72	0.00e+00	1342.00
IUUC-Tni-120113	Tetraodon nigroviridis	79.28	0.00e+00	1448.00
IUUC-Tbe-127408	Tupaia belangeri	77.32	0.00e+00	753.00
IUUC-Ttr-128235	Tursiops truncatus	90.55	0.00e+00	1009.00
IUUC-Vda-129753	Verticillium dahliae	45.93	1.00e-151	530.00
IUUC-Vpa-130503	Vicugna pacos	80.62	0.00e+00	806.00
IUUC-Xtr-132859	Xenopus tropicalis	79.28	0.00e+00	1487.00
IUUC-Xma-133797	Xiphophorus maculatus	85.50	0.00e+00	1594.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence