iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115535

Ensembl Protein ID

ENSSSCP00000024488.1

UniProt Accession

I3LK74; I3LK74_PIG

Protein Name

Uncharacterized protein

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000024373.1	ENSSSCT00000029290.1	ENSSSCP00000024488.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.90e-81	272.5	1650	2002

Active Site

Position(s)	Description	Evidence
1969	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1650 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1732
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaesdieelgldltfsvseeilgetkee 154
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl +vdp +++s+  +++ +  + + l+ d + ++++ ++   +  
   Q: 1733 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDVDPVVARSVYHLEDIVR-QKKRLEQDKSQTKESLQYALETLI 1818
           **********************************654444******************9964.445555566666666678888999 PP
   S: 155  eLkpgGenipVtneNkeeYvklvveyrlke...gikeqveafreGfneviplellslFteeelellicGe..eeidvedlkketkyk 236
           eLk gG++ipVt+ N+eeY +l++ + l+    g+   +  fr+Gf++v+pl++l++F +eel++l+cG+  +++d+++l + ++ +
   Q: 1819 ELKKGGKDIPVTIHNLEEYLRLLIYFELQAsnfGVSWDFLGFRDGFESVFPLSHLQYFYPEELDQLLCGSkaDTWDAKTLMECCRPD 1905
           9***************************9866679999999*****************************7778999999999999* PP
   S: 237  ggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....dasddrlPssnTCfnyLkLPeYsskei 318
           +gyt+ds+a+++++e+l++f+         FvTgs+rlP+gGf++l+p l+++rk     ++ dd lPs++TC+nyLkLP+Yss ei
   Q: 1906 HGYTHDSRAVKFLFEILSSFE---------FVTGSPRLPVGGFRSLNPPLTIVRKtfestENPDDFLPSVMTCVNYLKLPDYSSIEI 1983
           *******************95.........****************************988888*********************** PP
   S: 319  lkekLlyAieet.kgFels 336
           ++ekLl+A +e+ ++F+ls
   Q: 1984 MREKLLMAAREGqQSFHLS 2002
           ****************985 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSCSSSSA VIVPQPEDPD RANTSERQKT 60
GQVPKKDNSR GVKRSASPDY NRTNSPSSAK KPKALQHTES PSETNKPHSK SKKRHLDQEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTTTTTCC CTTTTTTTTT TTTTCCCCTT TTAGTGAATG GTAGTGTCTA GAAAGGGTAT 60
GTCCCTTCAA GAGAGAGGTG CCAATGTCCA ACCGGCCTAA TAACAATCCA GGGGGGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.46	3.00e-107	383.00
IUUC-Aml-001502	Ailuropoda melanoleuca	91.76	0.00e+00	3440.00
IUUC-Atr-002821	Amborella trichopoda	34.80	2.00e-98	354.00
IUUC-Apl-003531	Anas platyrhynchos	87.33	0.00e+00	3162.00
IUUC-Aly-005962	Arabidopsis lyrata	36.26	2.00e-95	344.00
IUUC-Ath-006636	Arabidopsis thaliana	36.26	3.00e-95	343.00
IUUC-Ago-007875	Ashbya gossypii	34.95	6.00e-70	259.00
IUUC-Acl-008242	Aspergillus clavatus	32.23	1.00e-90	328.00
IUUC-Afl-008736	Aspergillus flavus	35.04	7.00e-89	322.00
IUUC-Afu-008812	Aspergillus fumigatus	31.78	2.00e-91	331.00
IUUC-Ani-009407	Aspergillus nidulans	34.29	4.00e-90	327.00
IUUC-Ang-009763	Aspergillus niger	35.53	2.00e-87	318.00
IUUC-Aor-009941	Aspergillus oryzae	28.68	5.00e-91	329.00
IUUC-Ate-010459	Aspergillus terreus	32.68	3.00e-64	241.00
IUUC-Ame-011761	Astyanax mexicanus	84.04	0.00e+00	2799.00
IUUC-Bgr-012265	Blumeria graminis	31.82	6.00e-90	326.00
IUUC-Bta-013070	Bos taurus	93.11	0.00e+00	3458.00
IUUC-Bci-013890	Botrytis cinerea	36.18	2.00e-84	308.00
IUUC-Bdi-014046	Brachypodium distachyon	36.18	1.00e-103	371.00
IUUC-Bol-015942	Brassica oleracea	40.93	2.00e-95	344.00
IUUC-Bra-016849	Brassica rapa	40.93	3.00e-95	344.00
IUUC-Cja-019046	Callithrix jacchus	90.60	0.00e+00	3363.00
IUUC-Cfa-020521	Canis familiaris	89.92	0.00e+00	3291.00
IUUC-Cpo-021639	Cavia porcellus	87.48	0.00e+00	3281.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	37.89	1.00e-74	273.00
IUUC-Csa-023231	Chlorocebus sabaeus	92.82	0.00e+00	3438.00
IUUC-Cho-024380	Choloepus hoffmanni	89.84	0.00e+00	2046.00
IUUC-Cin-025482	Ciona intestinalis	47.49	1.00e-134	473.00
IUUC-Csv-026121	Ciona savignyi	46.58	0.00e+00	1437.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	32.08	5.00e-90	326.00
IUUC-Cne-026857	Cryptococcus neoformans	36.38	6.00e-77	283.00
IUUC-Cme-027226	Cyanidioschyzon merolae	32.02	4.00e-64	240.00
IUUC-Dre-028174	Danio rerio	83.91	0.00e+00	2846.00
IUUC-Dor-030939	Dipodomys ordii	82.77	0.00e+00	2598.00
IUUC-Dse-031444	Dothistroma septosporum	36.47	8.00e-87	316.00
IUUC-Dme-032162	Drosophila melanogaster	66.37	2.00e-169	590.00
IUUC-Ete-032345	Echinops telfairi	87.36	0.00e+00	2180.00
IUUC-Eca-033229	Equus caballus	91.08	0.00e+00	3350.00
IUUC-Eeu-035205	Erinaceus europaeus	83.46	0.00e+00	2954.00
IUUC-Fca-036444	Felis catus	90.99	0.00e+00	3381.00
IUUC-Fal-037131	Ficedula albicollis	88.67	0.00e+00	3274.00
IUUC-Fox-038035	Fusarium oxysporum	34.49	3.00e-87	316.00
IUUC-Fso-038320	Fusarium solani	34.04	2.00e-87	318.00
IUUC-Gmo-039497	Gadus morhua	82.71	0.00e+00	2814.00
IUUC-Ggr-040057	Gaeumannomyces graminis	32.18	5.00e-89	323.00
IUUC-Gga-041021	Gallus gallus	88.72	0.00e+00	3278.00
IUUC-Gac-042474	Gasterosteus aculeatus	79.37	0.00e+00	2880.00
IUUC-Gma-043060	Glycine max	36.04	5.00e-103	369.00
IUUC-Ggo-044855	Gorilla gorilla	90.65	0.00e+00	3366.00
IUUC-Hsa-046147	Homo sapiens	93.16	0.00e+00	3381.00
IUUC-Hvu-047775	Hordeum vulgare	36.46	1.00e-105	378.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.49	0.00e+00	3363.00
IUUC-Kpa-049098	Komagataella pastoris	36.42	9.00e-73	269.00
IUUC-Lch-049818	Latimeria chalumnae	83.02	0.00e+00	2959.00
IUUC-Lpe-051017	Leersia perrieri	35.66	3.00e-99	357.00
IUUC-Loc-051777	Lepisosteus oculatus	82.76	0.00e+00	3112.00
IUUC-Lma-052990	Leptosphaeria maculans	35.96	3.00e-90	327.00
IUUC-Laf-053727	Loxodonta africana	91.22	0.00e+00	3360.00
IUUC-Mcc-055799	Macaca mulatta	91.37	0.00e+00	3341.00
IUUC-Meu-056065	Macropus eugenii	90.66	0.00e+00	1991.00
IUUC-Mor-057054	Magnaporthe oryzae	31.78	1.00e-86	315.00
IUUC-Mpo-057417	Magnaporthe poae	35.96	3.00e-89	324.00
IUUC-Mtr-057849	Medicago truncatula	34.94	2.00e-96	347.00
IUUC-Mla-058870	Melampsora laricipopulina	39.08	5.00e-87	316.00
IUUC-Mga-059580	Meleagris gallopavo	88.53	0.00e+00	2855.00
IUUC-Mvi-060507	Microbotryum violaceum	36.53	2.00e-93	338.00
IUUC-Mmr-060816	Microcebus murinus	92.72	0.00e+00	3419.00
IUUC-Mdo-062866	Monodelphis domestica	88.31	0.00e+00	3145.00
IUUC-Mmu-063906	Mus musculus	93.75	0.00e+00	3421.00
IUUC-Mac-064675	Musa acuminata	35.85	6.00e-94	338.00
IUUC-Mpu-066199	Mustela putorius furo	91.51	0.00e+00	3362.00
IUUC-Mlu-067110	Myotis lucifugus	94.24	0.00e+00	3450.00
IUUC-Nfi-068482	Neosartorya fischeri	31.78	3.00e-91	330.00
IUUC-Ncr-068906	Neurospora crassa	36.09	7.00e-90	326.00
IUUC-Nle-069410	Nomascus leucogenys	91.13	0.00e+00	3346.00
IUUC-Opr-070401	Ochotona princeps	83.48	0.00e+00	1859.00
IUUC-Ont-072100	Oreochromis niloticus	78.88	0.00e+00	2926.00
IUUC-Oan-073121	Ornithorhynchus anatinus	89.16	0.00e+00	3393.00
IUUC-Ocu-074623	Oryctolagus cuniculus	90.89	0.00e+00	3350.00
IUUC-Oba-075380	Oryza barthii	34.38	2.00e-97	350.00
IUUC-Obr-076915	Oryza brachyantha	34.85	1.00e-99	358.00
IUUC-Ogl-077055	Oryza glaberrima	35.51	8.00e-99	355.00
IUUC-Ogu-078892	Oryza glumaepatula	37.96	2.00e-96	347.00
IUUC-Oin-079256	Oryza indica	35.35	8.00e-98	352.00
IUUC-Olo-080343	Oryza longistaminata	35.35	4.00e-98	353.00
IUUC-Ome-081422	Oryza meridionalis	35.07	9.00e-98	352.00
IUUC-Oni-082469	Oryza nivara	35.87	2.00e-99	357.00
IUUC-Opu-083792	Oryza punctata	34.38	1.00e-88	322.00
IUUC-Oru-084439	Oryza rufipogon	38.14	6.00e-97	349.00
IUUC-Osa-085972	Oryza sativa	35.37	4.00e-97	348.00
IUUC-Ola-087173	Oryzias latipes	79.81	0.00e+00	2932.00
IUUC-Olu-087871	Ostreococcus lucimarinus	34.18	1.00e-74	273.00
IUUC-Oga-087908	Otolemur garnettii	90.37	0.00e+00	3360.00
IUUC-Oar-090277	Ovis aries	94.29	0.00e+00	3508.00
IUUC-Ptr-091543	Pan troglodytes	93.26	0.00e+00	3387.00
IUUC-Pan-092243	Papio anubis	91.32	0.00e+00	3343.00
IUUC-Psi-093150	Pelodiscus sinensis	88.14	0.00e+00	3309.00
IUUC-Pno-094891	Phaeosphaeria nodorum	37.15	8.00e-92	332.00
IUUC-Ppa-095181	Physcomitrella patens	39.38	2.00e-89	323.00
IUUC-Pfo-096267	Poecilia formosa	78.17	0.00e+00	2902.00
IUUC-Pab-098072	Pongo abelii	90.74	0.00e+00	3365.00
IUUC-Pop-099190	Populus trichocarpa	37.65	3.00e-96	347.00
IUUC-Pca-100311	Procavia capensis	85.74	0.00e+00	3085.00
IUUC-Ppe-101284	Prunus persica	34.64	3.00e-95	343.00
IUUC-Pva-102215	Pteropus vampyrus	85.44	0.00e+00	1229.00
IUUC-Pgr-103694	Puccinia graminis	38.12	2.00e-85	311.00
IUUC-Ptt-103916	Puccinia triticina	36.35	3.00e-79	290.00
IUUC-Pte-104346	Pyrenophora teres	36.18	1.00e-89	325.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	36.55	2.00e-90	328.00
IUUC-Rno-105315	Rattus norvegicus	90.69	0.00e+00	3283.00
IUUC-Sce-106273	Saccharomyces cerevisiae	33.84	2.00e-60	228.00
IUUC-Sha-106835	Sarcophilus harrisii	90.80	0.00e+00	3425.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	35.89	2.00e-80	294.00
IUUC-Spo-108081	Schizosaccharomyces pombe	36.53	2.00e-79	291.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	36.18	3.00e-87	317.00
IUUC-Smo-109590	Selaginella moellendorffii	40.23	8.00e-95	342.00
IUUC-Sit-110717	Setaria italica	35.61	1.00e-101	365.00
IUUC-Sly-111469	Solanum lycopersicum	36.15	1.00e-102	368.00
IUUC-Stu-112896	Solanum tuberosum	35.35	2.00e-88	319.00
IUUC-Sar-113224	Sorex araneus	87.46	0.00e+00	1865.00
IUUC-Sbi-114313	Sorghum bicolor	35.25	8.00e-104	372.00
IUUC-Sre-114993	Sporisorium reilianum	32.85	6.00e-87	317.00
IUUC-Tgu-117493	Taeniopygia guttata	88.15	0.00e+00	2594.00
IUUC-Tru-118669	Takifugu rubripes	76.68	0.00e+00	2814.00
IUUC-Tsy-119373	Tarsius syrichta	90.77	0.00e+00	1754.00
IUUC-Tni-120049	Tetraodon nigroviridis	74.27	0.00e+00	832.00
IUUC-Tca-121779	Theobroma cacao	36.54	8.00e-98	352.00
IUUC-Tre-122195	Trichoderma reesei	32.93	3.00e-84	307.00
IUUC-Tvi-122650	Trichoderma virens	33.48	4.00e-88	320.00
IUUC-Tae-123580	Triticum aestivum	36.38	2.00e-105	376.00
IUUC-Tur-126295	Triticum urartu	36.31	2.00e-106	380.00
IUUC-Tme-126964	Tuber melanosporum	36.69	5.00e-85	310.00
IUUC-Tbe-128149	Tupaia belangeri	77.14	0.00e+00	1350.00
IUUC-Ttr-128165	Tursiops truncatus	90.23	0.00e+00	2886.00
IUUC-Uma-129365	Ustilago maydis	34.38	6.00e-74	273.00
IUUC-Vda-129725	Verticillium dahliae	38.05	1.00e-89	325.00
IUUC-Vpa-130678	Vicugna pacos	94.25	0.00e+00	2568.00
IUUC-Vvi-131147	Vitis vinifera	35.86	7.00e-101	362.00
IUUC-Xtr-132636	Xenopus tropicalis	83.95	0.00e+00	3105.00
IUUC-Xma-133458	Xiphophorus maculatus	78.69	0.00e+00	2945.00
IUUC-Yli-134481	Yarrowia lipolytica	37.37	7.00e-83	302.00
IUUC-Zma-135782	Zea mays	35.33	8.00e-100	359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence