iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035534

Ensembl Protein ID

ENSFCAP00000022100.1

UniProt Accession

M3X649; M3X649_FELCA

Genbank Protein ID

ENSFCAP00000022100

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AANG02002631

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000002655.2	ENSFCAT00000002655.2	ENSFCAP00000022100.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-89	301.0	288	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+     ++p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 288  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCVM---TSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 372
           9*****************************.9999987...578********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k        +         s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 373  DAHEFLIAILDVLHRHSKD-------D---------SVGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 445
           *****************22.......2.........233457899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 446  CATFSSqspegadstvsrddhipgipSLTDCLQWFTRPEYLGSSAKIKCSSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 532
           9887669999********************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++++  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 533  INTFISFPLELDMTPFLASTKDSRMKedqpptdctpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 619
           *****************99555554467778888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 620  -SEGYLLFYHKQ 630
           .********985 PP

Organism

Felis catus

Protein Sequence
(Fasta)

DLTWSDSGGD KEVLPSTPPR CYSSSSPLCP RRKPRPRPQP RVRARALPGP SAPPQPPAHP 60
PPQLLTRPQS WRRSRRRSRP GSRPQKLQSC SPDLGGSADR GGLGDWLLEV QFDQGPTGCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTGACGT GGAGTGACAG CGGCGGCGAT AAGGAGGTGC TCCCTTCAAC CCCACCTCGC 60
TGTTACAGCA GCTCTTCGCC CCTTTGCCCG CGCCGCAAGC CCCGCCCTCG GCCCCAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	92.13	0.00e+00	1023.00
IUUC-Csa-023824	Chlorocebus sabaeus	94.12	0.00e+00	990.00
IUUC-Eca-033872	Equus caballus	94.89	0.00e+00	1004.00
IUUC-Ggo-045109	Gorilla gorilla	93.10	0.00e+00	967.00
IUUC-Hsa-045765	Homo sapiens	95.07	0.00e+00	1007.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	94.70	0.00e+00	941.00
IUUC-Mcc-055420	Macaca mulatta	93.59	0.00e+00	1020.00
IUUC-Mla-059185	Melampsora laricipopulina	33.43	3.00e-43	169.00
IUUC-Mmr-061690	Microcebus murinus	94.37	0.00e+00	1020.00
IUUC-Mmu-063435	Mus musculus	80.19	0.00e+00	821.00
IUUC-Mac-065419	Musa acuminata	33.87	2.00e-73	269.00
IUUC-Mpu-065679	Mustela putorius furo	92.28	0.00e+00	1010.00
IUUC-Mlu-067084	Myotis lucifugus	92.74	0.00e+00	1005.00
IUUC-Nle-069859	Nomascus leucogenys	95.26	0.00e+00	1008.00
IUUC-Ocu-074365	Oryctolagus cuniculus	92.26	0.00e+00	958.00
IUUC-Ptr-091479	Pan troglodytes	94.88	0.00e+00	1008.00
IUUC-Pan-091707	Papio anubis	93.93	0.00e+00	987.00
IUUC-Pab-097894	Pongo abelii	94.91	0.00e+00	1010.00
IUUC-Rno-105644	Rattus norvegicus	80.51	0.00e+00	840.00
IUUC-Sar-113426	Sorex araneus	80.78	0.00e+00	828.00
IUUC-Ssc-115500	Sus scrofa	92.05	0.00e+00	974.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence