iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097894

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ABGA01164066

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000020395.1	ENSPPYT00000023792.1	ENSPPYP00000022830.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-90	302.6	364	706

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 364  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 448
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k                  s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 449  DAHEFLIAILDVLHRHSKD----------------DSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 521
           *****************22................1223456899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 522  CATFDSqnperadstvsrddhipgipSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 608
           98776689999*******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 609  INTFISFPLELDMTPFLASTKESRMKegqpptdcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 695
           *****************99665555578888888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 696  -SEGYLLFYHKQ 706
           .********985 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAQVRETSLP SGSGARWISG GGGGASPEEA VEKAEKMEEA AAGATKASSR REAEEMKLEP 60
LQEREPAPEE NLTWSSSGGD EKVLPSIPLR CHSSSSPVCP RRKPRPRPQP RARSRSQPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAGG TTCGAGAAAC TTCTTTGCCC TCCGGCTCTG GGGCCCGTTG GATCTCCGGA 60
GGTGGGGGAG GAGCCTCTCC TGAGGAGGCG GTTGAGAAGG CGGAGAAAAT GGAGGAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pon:100439953

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	93.36	0.00e+00	992.00
IUUC-Cja-019402	Callithrix jacchus	96.92	0.00e+00	755.00
IUUC-Csa-023824	Chlorocebus sabaeus	98.48	0.00e+00	1045.00
IUUC-Eca-033872	Equus caballus	94.32	0.00e+00	1002.00
IUUC-Fca-035534	Felis catus	93.65	0.00e+00	1009.00
IUUC-Ggo-045109	Gorilla gorilla	96.93	0.00e+00	1014.00
IUUC-Hsa-045765	Homo sapiens	99.16	0.00e+00	1152.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	94.89	0.00e+00	956.00
IUUC-Mcc-055420	Macaca mulatta	97.99	0.00e+00	1078.00
IUUC-Mmr-061690	Microcebus murinus	94.93	0.00e+00	1035.00
IUUC-Mmu-063435	Mus musculus	80.60	0.00e+00	832.00
IUUC-Mac-065419	Musa acuminata	33.87	3.00e-74	272.00
IUUC-Mpu-065679	Mustela putorius furo	94.12	0.00e+00	983.00
IUUC-Mlu-067084	Myotis lucifugus	92.20	0.00e+00	1004.00
IUUC-Nle-069859	Nomascus leucogenys	99.62	0.00e+00	1062.00
IUUC-Ocu-074365	Oryctolagus cuniculus	93.40	0.00e+00	977.00
IUUC-Ptr-091479	Pan troglodytes	98.73	0.00e+00	1193.00
IUUC-Pan-091707	Papio anubis	98.29	0.00e+00	1041.00
IUUC-Rno-105644	Rattus norvegicus	79.60	0.00e+00	843.00
IUUC-Sar-113426	Sorex araneus	80.00	0.00e+00	833.00
IUUC-Ssc-115500	Sus scrofa	91.30	0.00e+00	984.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence