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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045970
Ensembl Protein ID ENSP00000384545.1
UniProt Accession Q9Y2F9; D3DW19; Q5JY73; BTBD3_HUMAN
Genbank Protein ID BAA76796.2; CAC22147.1; CAI22619.1; EAX10327.1; EAX10328.1; AAI01528.1; AAI09316.1; AAI09317.1
Protein Name BTB/POZ domain-containing protein 3
Genbank Nucleotide ID AB023169; AL035448; AL035448; CH471133; CH471133; BC101527; BC109315; BC109316
Gene Name BTBD3; KIAA0952
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132640.14 ENST00000405977.5 ENSP00000384545.1
ENSG00000132640.14 ENST00000449299.5 ENSP00000410502.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.20e-15 59.3 120 188
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           aDv +vvg     ++ + hk+vLa  SsvF+a+f++el e   k+++ i dv+p +f a+lk++Y++++d+
   Q: 120  ADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAED--KDEIRIPDVEPAAFLAMLKYIYCDEIDL 188
           69*****555569***************************8..6************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).
 Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).
Protein Sequence
(Fasta)
MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKANTSSSSS NSSKLPPVCY EIITLKTKKK 60
KMAADIFPRK KPANSSSTSV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN AMMFNNDLMA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045970|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCGCATG CCCCGTATCC AAGGCCGCCT CCGGGAGCAC CTCCCATGCC GCTCCGCTCC 60
CTCCCGGTGA CCGGGCACGC GCGCTCGCTC CCGCAGAGCG TGCCCTGCGT GCGGGTGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045970|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR
SMART

SM00875--BACK
SM00225--BTB
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0021987--P:cerebral cortex development
GO:0048813--P:dendrite morphogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG hsa:22903
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002161 Ailuropoda melanoleuca 97.72 0.00e+00 984.00
IUUC-Apl-003517 Anas platyrhynchos 94.46 0.00e+00 959.00
IUUC-Aca-005304 Anolis carolinensis 96.31 0.00e+00 920.00
IUUC-Ame-010761 Astyanax mexicanus 88.71 0.00e+00 802.00
IUUC-Bta-012570 Bos taurus 96.77 0.00e+00 960.00
IUUC-Cja-019511 Callithrix jacchus 99.62 0.00e+00 1022.00
IUUC-Cfa-020647 Canis familiaris 99.57 0.00e+00 965.00
IUUC-Cpo-021351 Cavia porcellus 96.62 0.00e+00 1004.00
IUUC-Csa-024059 Chlorocebus sabaeus 99.78 0.00e+00 966.00
IUUC-Cho-025005 Choloepus hoffmanni 97.71 0.00e+00 999.00
IUUC-Cin-025639 Ciona intestinalis 66.51 5.00e-175 607.00
IUUC-Csv-026142 Ciona savignyi 67.97 1.00e-171 595.00
IUUC-Dre-028307 Danio rerio 87.76 0.00e+00 872.00
IUUC-Dno-029035 Dasypus novemcinctus 98.12 0.00e+00 960.00
IUUC-Dor-030552 Dipodomys ordii 98.80 4.00e-143 501.00
IUUC-Dme-032181 Drosophila melanogaster 68.76 1.00e-180 626.00
IUUC-Ete-032361 Echinops telfairi 94.84 0.00e+00 967.00
IUUC-Eca-034159 Equus caballus 98.96 0.00e+00 971.00
IUUC-Eeu-035112 Erinaceus europaeus 97.43 9.00e-140 490.00
IUUC-Fca-036566 Felis catus 97.16 0.00e+00 1005.00
IUUC-Fal-036746 Ficedula albicollis 96.96 0.00e+00 913.00
IUUC-Gmo-039441 Gadus morhua 84.70 0.00e+00 865.00
IUUC-Gga-040851 Gallus gallus 95.41 0.00e+00 959.00
IUUC-Gac-042237 Gasterosteus aculeatus 86.04 0.00e+00 860.00
IUUC-Ggo-044742 Gorilla gorilla 98.08 0.00e+00 1020.00
IUUC-Itr-048115 Ictidomys tridecemlineatus 98.28 0.00e+00 1009.00
IUUC-Lch-050181 Latimeria chalumnae 88.17 0.00e+00 886.00
IUUC-Loc-051843 Lepisosteus oculatus 93.93 0.00e+00 871.00
IUUC-Laf-053856 Loxodonta africana 96.58 0.00e+00 986.00
IUUC-Mcc-054976 Macaca mulatta 99.78 0.00e+00 966.00
IUUC-Meu-056720 Macropus eugenii 95.60 0.00e+00 968.00
IUUC-Mga-059773 Meleagris gallopavo 95.41 0.00e+00 959.00
IUUC-Mmr-060616 Microcebus murinus 89.56 0.00e+00 861.00
IUUC-Mdo-062550 Monodelphis domestica 96.37 0.00e+00 966.00
IUUC-Mmu-064102 Mus musculus 95.28 0.00e+00 972.00
IUUC-Mpu-066911 Mustela putorius furo 99.57 0.00e+00 965.00
IUUC-Mlu-067224 Myotis lucifugus 97.18 0.00e+00 1013.00
IUUC-Nle-069698 Nomascus leucogenys 99.79 0.00e+00 1000.00
IUUC-Opr-070684 Ochotona princeps 97.90 0.00e+00 1005.00
IUUC-Ont-072550 Oreochromis niloticus 89.10 0.00e+00 881.00
IUUC-Oan-072789 Ornithorhynchus anatinus 95.79 0.00e+00 963.00
IUUC-Ocu-074474 Oryctolagus cuniculus 99.57 0.00e+00 965.00
IUUC-Ola-087257 Oryzias latipes 87.76 0.00e+00 874.00
IUUC-Oga-088423 Otolemur garnettii 97.72 0.00e+00 1006.00
IUUC-Oar-089546 Ovis aries 97.15 0.00e+00 1001.00
IUUC-Ptr-090861 Pan troglodytes 99.81 0.00e+00 1024.00
IUUC-Pan-092637 Papio anubis 99.78 0.00e+00 966.00
IUUC-Psi-093667 Pelodiscus sinensis 97.18 0.00e+00 914.00
IUUC-Pma-094204 Petromyzon marinus 83.07 0.00e+00 681.00
IUUC-Pfo-097155 Poecilia formosa 83.75 0.00e+00 867.00
IUUC-Pab-097700 Pongo abelii 99.79 0.00e+00 999.00
IUUC-Pca-100199 Procavia capensis 97.18 0.00e+00 806.00
IUUC-Pva-102923 Pteropus vampyrus 99.04 0.00e+00 1014.00
IUUC-Rno-105022 Rattus norvegicus 95.64 0.00e+00 973.00
IUUC-Sar-113399 Sorex araneus 97.33 0.00e+00 1004.00
IUUC-Ssc-115621 Sus scrofa 97.53 0.00e+00 1007.00
IUUC-Tgu-116670 Taeniopygia guttata 95.22 0.00e+00 959.00
IUUC-Tru-118366 Takifugu rubripes 85.93 0.00e+00 858.00
IUUC-Tsy-119141 Tarsius syrichta 98.67 0.00e+00 1009.00
IUUC-Tni-120629 Tetraodon nigroviridis 87.19 0.00e+00 869.00
IUUC-Tbe-127769 Tupaia belangeri 87.86 0.00e+00 879.00
IUUC-Vpa-130749 Vicugna pacos 97.90 0.00e+00 1006.00
IUUC-Xtr-131984 Xenopus tropicalis 89.29 0.00e+00 875.00
Created Date 25-Jun-2017

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