iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027636

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BX640518

Gene Name

BX640518.1; socs6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000058565.2	ENSDART00000081449.2	ENSDARP00000075890.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.70e-17	62.2	472	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 472  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 519
           5788999********************888...***************997 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MKKISLKTIR KSLNIKGKED GDFVMLQQPT IAAEFTKDDT LFGGCYTKGL VGCDLNGEDE 60
KGHKSRSKSE SLMGTLKRRL STKQKAKVKG GSSAVGSGDD DDTFSSSSVP ISFNEVKAQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTACCGCTA GTTCACTTAT TCACAATTCA TTTTATCTCA CTTTTTTTGC AGATGACGGT 60
CACATGATTG ACGTTTCTCA GTCACATGGC CGGACTCTGC GGTTAGCATC CATCGGTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

dre:558703

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	70.90	0.00e+00	660.00
IUUC-Apl-004035	Anas platyrhynchos	70.90	0.00e+00	678.00
IUUC-Aca-004782	Anolis carolinensis	69.96	0.00e+00	658.00
IUUC-Ame-011790	Astyanax mexicanus	76.94	0.00e+00	694.00
IUUC-Bta-012579	Bos taurus	92.12	2.00e-101	362.00
IUUC-Bol-015843	Brassica oleracea	28.77	2.50e-02	33.50
IUUC-Cja-019528	Callithrix jacchus	69.96	0.00e+00	683.00
IUUC-Cfa-020678	Canis familiaris	70.34	0.00e+00	690.00
IUUC-Cpo-021947	Cavia porcellus	70.52	0.00e+00	692.00
IUUC-Csa-023935	Chlorocebus sabaeus	69.44	0.00e+00	686.00
IUUC-Cho-024477	Choloepus hoffmanni	68.47	0.00e+00	672.00
IUUC-Cin-025413	Ciona intestinalis	67.65	3.00e-65	242.00
IUUC-Csv-026247	Ciona savignyi	66.87	5.00e-64	238.00
IUUC-Dno-029048	Dasypus novemcinctus	69.59	0.00e+00	683.00
IUUC-Dor-030401	Dipodomys ordii	68.89	0.00e+00	662.00
IUUC-Ete-033116	Echinops telfairi	41.55	3.00e-47	182.00
IUUC-Eca-033825	Equus caballus	70.34	0.00e+00	668.00
IUUC-Fca-036253	Felis catus	69.40	5.00e-178	617.00
IUUC-Fal-037614	Ficedula albicollis	71.08	0.00e+00	680.00
IUUC-Gmo-038928	Gadus morhua	76.78	0.00e+00	727.00
IUUC-Gga-040177	Gallus gallus	71.27	0.00e+00	681.00
IUUC-Gac-042263	Gasterosteus aculeatus	78.92	0.00e+00	793.00
IUUC-Ggo-045288	Gorilla gorilla	69.59	0.00e+00	686.00
IUUC-Hsa-046409	Homo sapiens	70.15	0.00e+00	689.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	70.15	0.00e+00	662.00
IUUC-Lch-050354	Latimeria chalumnae	72.25	0.00e+00	713.00
IUUC-Loc-052319	Lepisosteus oculatus	77.17	0.00e+00	768.00
IUUC-Laf-054070	Loxodonta africana	68.89	0.00e+00	686.00
IUUC-Mcc-055045	Macaca mulatta	69.44	0.00e+00	686.00
IUUC-Meu-055917	Macropus eugenii	70.34	0.00e+00	701.00
IUUC-Mga-059273	Meleagris gallopavo	71.08	0.00e+00	691.00
IUUC-Mmr-061597	Microcebus murinus	70.34	0.00e+00	684.00
IUUC-Mdo-062492	Monodelphis domestica	40.00	1.00e-50	193.00
IUUC-Mmu-063374	Mus musculus	65.81	2.00e-176	612.00
IUUC-Mpu-065967	Mustela putorius furo	69.78	0.00e+00	661.00
IUUC-Mlu-067532	Myotis lucifugus	69.81	0.00e+00	677.00
IUUC-Nle-069373	Nomascus leucogenys	70.15	0.00e+00	688.00
IUUC-Opr-070873	Ochotona princeps	68.33	0.00e+00	702.00
IUUC-Ont-072498	Oreochromis niloticus	78.73	0.00e+00	795.00
IUUC-Oan-072943	Ornithorhynchus anatinus	57.99	1.00e-73	270.00
IUUC-Ocu-073870	Oryctolagus cuniculus	69.63	0.00e+00	662.00
IUUC-Ola-086866	Oryzias latipes	92.14	2.00e-113	401.00
IUUC-Oga-089057	Otolemur garnettii	68.89	0.00e+00	662.00
IUUC-Oar-089841	Ovis aries	52.06	8.00e-131	460.00
IUUC-Ptr-091054	Pan troglodytes	69.96	0.00e+00	687.00
IUUC-Pma-094253	Petromyzon marinus	64.66	4.00e-94	338.00
IUUC-Pfo-097179	Poecilia formosa	73.51	0.00e+00	684.00
IUUC-Pab-097702	Pongo abelii	70.34	0.00e+00	691.00
IUUC-Pca-100671	Procavia capensis	63.05	5.00e-81	295.00
IUUC-Rno-106044	Rattus norvegicus	64.16	5.00e-175	607.00
IUUC-Sha-107139	Sarcophilus harrisii	67.54	6.00e-178	617.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	4.40e-02	32.00
IUUC-Sly-111748	Solanum lycopersicum	23.01	1.30e+00	27.70
IUUC-Ssc-115343	Sus scrofa	69.07	0.00e+00	669.00
IUUC-Tgu-117061	Taeniopygia guttata	71.27	0.00e+00	682.00
IUUC-Tni-119829	Tetraodon nigroviridis	75.89	0.00e+00	721.00
IUUC-Ttr-129148	Tursiops truncatus	69.44	0.00e+00	642.00
IUUC-Vpa-130780	Vicugna pacos	68.15	4.00e-180	624.00
IUUC-Vvi-130966	Vitis vinifera	32.69	6.30e-02	31.20
IUUC-Xtr-132513	Xenopus tropicalis	68.28	0.00e+00	665.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence