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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063460
UUCD1 version UUC-MuM-01057
Ensembl Protein ID ENSMUSP00000002825.5
UniProt Accession Q9Z277; B9EJ99; Q3URP5; Q3USR7; Q3UVM2; Q8CAU9; Q9CU68; BAZ1B_MOUSE
Genbank Protein ID AAD08676.1; EDL19376.1; AAI41400.1; BAB30992.1; BAC29862.1; BAE23247.1; BAE24264.1; BAE24643.1
Protein Name Tyrosine-protein kinase BAZ1B; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor homolog; Williams-Beuren syndrome chromosomal region 9 protein homolog
Genbank Nucleotide ID AF084480; CH466529; BC141399; AK017894; AK037737; AK137139; AK140172; AK141305
Gene Name Baz1b; Wbscr9; Wstf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000002748.7 ENSMUST00000002825.5 ENSMUSP00000002825.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.10e-12 46.3 1185 1232
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC+++ged+ +l+ C++C+++fH  Cl ++   e+p+ e w Cp C+
   Q: 1185 ARCKVCRKKGEDD-KLILCDECNKAFHLFCLRPA-LYEVPDGE-WQCPACQ 1232
           57*********98.6*******************.*******8.******6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
 Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Protein Sequence
(Fasta)
MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL 60
THKEAWEEEQ EVAELLKEEF PNWYEKLVLE MVHHNTASLE KLVDSAWLEI MTKYAVGEEC 120
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Protein Fasta Sequence


>IUUC-Mmu-063460|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
AGTCTGTGCG CTGGCCCGGC AGCGGGGGGG AGGAAGGGAA TCTCCCGCCA TTTTTCAATA 60
ATTTCCTCCC GTGCCCGCTG GAGAGGAGTC GTGACTGGCG GCCGCCGCGG CGGAGATCGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063460|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD
Gene Ontology

GO:0000793--C:condensed chromosome
GO:0016604--C:nuclear body
GO:0043596--C:nuclear replication fork
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0035173--F:histone kinase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0071884--F:vitamin D receptor activator activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006333--P:chromatin assembly or disassembly
GO:0006338--P:chromatin remodeling
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0006302--P:double-strand break repair
GO:0003007--P:heart morphogenesis
GO:0016572--P:histone phosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:22385
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002113 Ailuropoda melanoleuca 90.62 0.00e+00 2280.00
IUUC-Apl-003454 Anas platyrhynchos 78.33 0.00e+00 2080.00
IUUC-Ame-011469 Astyanax mexicanus 61.43 0.00e+00 1250.00
IUUC-Bta-012408 Bos taurus 89.70 0.00e+00 2363.00
IUUC-Cja-019194 Callithrix jacchus 89.64 0.00e+00 2347.00
IUUC-Cfa-021083 Canis familiaris 90.33 0.00e+00 2351.00
IUUC-Cpo-021422 Cavia porcellus 89.58 0.00e+00 2235.00
IUUC-Csa-023848 Chlorocebus sabaeus 91.12 0.00e+00 2407.00
IUUC-Dre-027895 Danio rerio 61.94 0.00e+00 1287.00
IUUC-Dno-029686 Dasypus novemcinctus 89.54 0.00e+00 2363.00
IUUC-Dor-030625 Dipodomys ordii 80.00 0.00e+00 1260.00
IUUC-Ete-032702 Echinops telfairi 89.61 0.00e+00 961.00
IUUC-Eca-033647 Equus caballus 90.69 0.00e+00 2338.00
IUUC-Eeu-034626 Erinaceus europaeus 85.38 0.00e+00 1915.00
IUUC-Fca-036092 Felis catus 89.99 0.00e+00 1945.00
IUUC-Fal-037127 Ficedula albicollis 77.76 0.00e+00 2080.00
IUUC-Gmo-039455 Gadus morhua 57.55 0.00e+00 1367.00
IUUC-Gga-041120 Gallus gallus 77.96 0.00e+00 2022.00
IUUC-Gac-041873 Gasterosteus aculeatus 58.64 0.00e+00 1405.00
IUUC-Ggo-045317 Gorilla gorilla 91.03 0.00e+00 2337.00
IUUC-Hsa-046773 Homo sapiens 91.05 0.00e+00 2390.00
IUUC-Itr-049026 Ictidomys tridecemlineatus 89.65 0.00e+00 2288.00
IUUC-Lch-050271 Latimeria chalumnae 67.60 0.00e+00 1599.00
IUUC-Loc-052699 Lepisosteus oculatus 64.31 0.00e+00 983.00
IUUC-Mcc-055171 Macaca mulatta 91.12 0.00e+00 2407.00
IUUC-Meu-055990 Macropus eugenii 81.82 0.00e+00 1910.00
IUUC-Mga-059913 Meleagris gallopavo 77.43 0.00e+00 1923.00
IUUC-Mmr-061681 Microcebus murinus 91.32 0.00e+00 2382.00
IUUC-Mdo-062486 Monodelphis domestica 84.34 0.00e+00 2144.00
IUUC-Mpu-066324 Mustela putorius furo 88.21 0.00e+00 1213.00
IUUC-Mlu-067334 Myotis lucifugus 90.05 0.00e+00 2424.00
IUUC-Nle-069983 Nomascus leucogenys 91.12 0.00e+00 2417.00
IUUC-Opr-070678 Ochotona princeps 78.37 0.00e+00 716.00
IUUC-Ont-071565 Oreochromis niloticus 60.88 0.00e+00 949.00
IUUC-Ocu-074779 Oryctolagus cuniculus 88.51 0.00e+00 2270.00
IUUC-Obr-076214 Oryza brachyantha 44.59 9.00e-13 70.50
IUUC-Ola-086746 Oryzias latipes 59.56 0.00e+00 1317.00
IUUC-Oga-088475 Otolemur garnettii 87.50 0.00e+00 2293.00
IUUC-Oar-090191 Ovis aries 88.26 0.00e+00 2264.00
IUUC-Ptr-090963 Pan troglodytes 91.39 0.00e+00 2382.00
IUUC-Pan-091819 Papio anubis 89.48 0.00e+00 1848.00
IUUC-Psi-093967 Pelodiscus sinensis 79.25 0.00e+00 1957.00
IUUC-Pfo-096939 Poecilia formosa 58.18 0.00e+00 978.00
IUUC-Pab-098679 Pongo abelii 90.81 0.00e+00 2227.00
IUUC-Pop-099061 Populus trichocarpa 65.52 6.00e-09 55.10
IUUC-Pva-102969 Pteropus vampyrus 90.66 0.00e+00 2193.00
IUUC-Rno-104927 Rattus norvegicus 97.57 0.00e+00 2455.00
IUUC-Sha-107021 Sarcophilus harrisii 81.61 0.00e+00 1971.00
IUUC-Ssc-116243 Sus scrofa 90.58 0.00e+00 2370.00
IUUC-Tgu-117073 Taeniopygia guttata 74.86 0.00e+00 1739.00
IUUC-Tru-118265 Takifugu rubripes 58.70 0.00e+00 1348.00
IUUC-Ttr-128885 Tursiops truncatus 87.10 0.00e+00 1923.00
IUUC-Xtr-131812 Xenopus tropicalis 62.57 0.00e+00 1511.00
Created Date 25-Jun-2017

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