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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063429
UUCD1 version UUC-MuM-00793
Ensembl Protein ID ENSMUSP00000061234.3
UniProt Accession Q8R3Y8; Q8BJC9; Q8C0B1; Q8CI76; I2BP1_MOUSE
Genbank Protein ID BAC27572.1; BAC39883.1; AAH19164.2; AAH36162.1
Protein Name Interferon regulatory factor 2-binding protein 1; Probable E3 ubiquitin-protein ligase IRF2BP1; Probable RING-type E3 ubiquitin transferase IRF2BP1
Genbank Nucleotide ID AK031834; AK087457; BC019164; BC036162
Gene Name Irf2bp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000044030.4 ENSMUST00000053713.4 ENSMUSP00000061234.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 96.40 0.00e+00 912.00 IUUC-Hsa-046110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
 Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
Protein Sequence
(Fasta)
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV 60
LPEGRSPGPP ALKHPTSKDL ASTGSQGSQL PPPQAQAQPS GTGGSVSGPD RYDRATSSSR 120
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Protein Fasta Sequence


>IUUC-Mmu-063429|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GCGGCCTCTG GGGCAGAAGA AGGAGGTGGA GGCGACGGCG GCCGTTGCAG CGGCGTCGGC 60
GGCGCGAGCG GAGCGGCGGG AGCCTGGGGC GGCGGCGCCC GAGGCCCATC GAGGAGCTGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063429|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022750--Interferon_reg_fac2-bd1_2_Znf
IPR018957--Znf_C3HC4_RING-type
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF11261--IRF-2BP1_2
PF00097--zf-C3HC4
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0016740--F:transferase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG mmu:272359
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000186 Aegilops tauschii 35.59 9.00e-03 32.30
IUUC-Aca-004493 Anolis carolinensis 59.01 0.00e+00 635.00
IUUC-Bta-012691 Bos taurus 93.12 0.00e+00 847.00
IUUC-Cfa-020153 Canis familiaris 96.23 0.00e+00 943.00
IUUC-Cpo-021918 Cavia porcellus 94.62 0.00e+00 928.00
IUUC-Csa-023365 Chlorocebus sabaeus 95.89 0.00e+00 944.00
IUUC-Dre-027787 Danio rerio 49.21 3.00e-147 515.00
IUUC-Dno-029864 Dasypus novemcinctus 95.04 0.00e+00 986.00
IUUC-Dor-030217 Dipodomys ordii 96.08 0.00e+00 729.00
IUUC-Eca-033451 Equus caballus 95.62 0.00e+00 927.00
IUUC-Fca-035677 Felis catus 95.55 0.00e+00 953.00
IUUC-Gmo-039514 Gadus morhua 41.96 4.00e-83 302.00
IUUC-Ggo-045243 Gorilla gorilla 96.23 0.00e+00 943.00
IUUC-Hsa-046110 Homo sapiens 96.40 0.00e+00 945.00
IUUC-Itr-048330 Ictidomys tridecemlineatus 96.92 0.00e+00 944.00
IUUC-Mcc-055423 Macaca mulatta 95.72 0.00e+00 942.00
IUUC-Meu-056349 Macropus eugenii 73.45 2.00e-161 561.00
IUUC-Mmr-061735 Microcebus murinus 96.06 0.00e+00 942.00
IUUC-Mdo-062840 Monodelphis domestica 71.01 8.00e-136 477.00
IUUC-Mpu-066580 Mustela putorius furo 95.72 0.00e+00 944.00
IUUC-Nle-069106 Nomascus leucogenys 96.06 0.00e+00 952.00
IUUC-Ont-071903 Oreochromis niloticus 43.42 9.00e-86 311.00
IUUC-Ocu-074681 Oryctolagus cuniculus 76.00 8.00e-180 623.00
IUUC-Obr-076824 Oryza brachyantha 24.20 1.30e-01 30.40
IUUC-Oga-088405 Otolemur garnettii 94.52 0.00e+00 969.00
IUUC-Oar-089381 Ovis aries 92.70 0.00e+00 702.00
IUUC-Ptr-091612 Pan troglodytes 96.40 0.00e+00 945.00
IUUC-Pan-091919 Papio anubis 95.89 0.00e+00 948.00
IUUC-Pfo-096484 Poecilia formosa 48.76 7.00e-123 434.00
IUUC-Pab-098642 Pongo abelii 96.23 0.00e+00 946.00
IUUC-Ppe-101159 Prunus persica 29.63 2.70e-02 33.10
IUUC-Pva-102937 Pteropus vampyrus 95.21 0.00e+00 978.00
IUUC-Rno-105343 Rattus norvegicus 99.66 0.00e+00 921.00
IUUC-Sly-111785 Solanum lycopersicum 31.88 1.70e-02 32.70
IUUC-Ssc-115265 Sus scrofa 95.72 0.00e+00 952.00
IUUC-Tru-117754 Takifugu rubripes 41.75 1.00e-107 383.00
Created Date 25-Jun-2017

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