iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021702

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02013690

Gene Name

TRIM59

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000006122.3	ENSCPOT00000006186.2	ENSCPOP00000005522.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.50e-07	29.3	6	89
E3 activity/RING/RING	7.50e-09	36.0	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           +e++CpI + +++dP +lp+ +t+ rs++e  l+ +g+           +cP +r+ +       e+l  n +lr++i+++ +e
   Q: 6    DELMCPICYSIFEDPRILPCSHTFCRSCLESVLQASGNfyiwrplriplKCPNCRSVTeitptGIESLPVNFALRAIIEKYQQE 89
           799******************************999999**********99999986644221345666699999999999876 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p++lpC H+f+++Cl+ +     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRILPCSHTFCRSCLESV----LQASGNFYiwrplriplkCPNCR 60
           **********.**************9888....566666666666666666****8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MHNFEDELMC PICYSIFEDP RILPCSHTFC RSCLESVLQA SGNFYIWRPL RIPLKCPNCR 60
SVTEITPTGI ESLPVNFALR AIIEKYQQED HPDVIFCPEH YKQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACAATT TTGAGGATGA GTTAATGTGT CCCATTTGTT ACAGTATTTT TGAAGATCCT 60
CGTATTCTAC CATGCTCTCA TACATTTTGT AGAAGTTGTT TGGAAAGTGT TCTTCAGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	78.86	0.00e+00	649.00
IUUC-Apl-003996	Anas platyrhynchos	62.96	7.00e-114	403.00
IUUC-Aca-005141	Anolis carolinensis	54.11	7.00e-121	426.00
IUUC-Ame-011353	Astyanax mexicanus	49.67	1.00e-92	333.00
IUUC-Bta-013440	Bos taurus	80.33	3.00e-174	603.00
IUUC-Cfa-021168	Canis familiaris	79.95	0.00e+00	656.00
IUUC-Csa-024141	Chlorocebus sabaeus	76.87	2.00e-165	575.00
IUUC-Dre-028408	Danio rerio	45.34	2.00e-83	302.00
IUUC-Dno-029180	Dasypus novemcinctus	77.11	0.00e+00	630.00
IUUC-Eca-034357	Equus caballus	78.95	0.00e+00	635.00
IUUC-Fca-036287	Felis catus	79.60	0.00e+00	657.00
IUUC-Gga-040739	Gallus gallus	55.22	3.00e-126	444.00
IUUC-Ggo-045307	Gorilla gorilla	76.44	6.00e-175	606.00
IUUC-Hsa-045690	Homo sapiens	76.62	3.00e-175	607.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	80.35	0.00e+00	668.00
IUUC-Laf-054522	Loxodonta africana	77.06	0.00e+00	638.00
IUUC-Mcc-055145	Macaca mulatta	77.36	2.00e-177	615.00
IUUC-Meu-056214	Macropus eugenii	45.65	5.00e-54	204.00
IUUC-Mmr-061197	Microcebus murinus	80.35	0.00e+00	668.00
IUUC-Mdo-062631	Monodelphis domestica	57.58	9.00e-122	429.00
IUUC-Mmu-064217	Mus musculus	75.87	9.00e-176	609.00
IUUC-Mpu-065691	Mustela putorius furo	80.10	0.00e+00	662.00
IUUC-Mlu-067742	Myotis lucifugus	77.89	7.00e-178	616.00
IUUC-Nle-069722	Nomascus leucogenys	75.87	0.00e+00	631.00
IUUC-Oan-073382	Ornithorhynchus anatinus	55.16	6.00e-120	423.00
IUUC-Oar-089206	Ovis aries	78.30	0.00e+00	655.00
IUUC-Pan-092189	Papio anubis	77.61	5.00e-178	616.00
IUUC-Psi-093523	Pelodiscus sinensis	57.49	5.00e-131	460.00
IUUC-Pma-094162	Petromyzon marinus	33.54	1.00e-46	179.00
IUUC-Pfo-096032	Poecilia formosa	44.30	8.00e-82	297.00
IUUC-Pva-103089	Pteropus vampyrus	79.90	0.00e+00	629.00
IUUC-Rno-105440	Rattus norvegicus	76.62	2.00e-177	615.00
IUUC-Ssc-115809	Sus scrofa	78.86	6.00e-178	616.00
IUUC-Tru-118402	Takifugu rubripes	42.86	7.00e-84	303.00
IUUC-Tni-119737	Tetraodon nigroviridis	42.12	2.00e-80	292.00
IUUC-Ttr-128921	Tursiops truncatus	78.95	0.00e+00	628.00
IUUC-Vpa-130397	Vicugna pacos	79.35	0.00e+00	659.00
IUUC-Xtr-132752	Xenopus tropicalis	47.30	7.00e-86	310.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence