iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027878

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CR749747

Gene Name

usp44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000089861.2	ENSDART00000124514.2	ENSDARP00000104741.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-97	328.0	295	683

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+                 ++                                       
   Q: 295  TGLRNLGNTCYMNSILQVLSHLHVFRECFLRldlnqaleL-------LASavsrklglsaqrviqpkglnqgsglsggasrsrnmeliq 376
           7******************************744333330.......333666777777778899999999999999999999999999 PP
   S: 43   ....kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedksels 127
               ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el++           + + ++ 
   Q: 377  pkepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWQLIPAFRGYAQQDAQEFLCELLDKVQHELERT---------RTLTPATV 456
           988899999************************************************************552.........22233344 PP
   S: 128  deaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesftkeeelegenkyyce 209
             ++++  k+  s+++++F+gql sq++cl+cd++s++ epf+dlsl++p++ +++ +        l+++L++ft++e leg+  y c+
   Q: 457  PANQRRLIKQVLSVVNTIFHGQLLSQVRCLACDHRSNTIEPFWDLSLEFPERYHSNSKdaaqvpcGLTEMLAKFTETEALEGAI-YACD 544
           557899********************************************999887779999999****************965.**** PP
   S: 210  kckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvv 285
            c++k++           a+k+l+++klP+vL lhLkRf++s + ++reki  +v+f +eL+++p+c++++ +  +  +  Y+L+avv+
   Q: 545  YCNNKRRrfcskqvvlteAQKQLMVHKLPHVLRLHLKRFRWSGR-NHREKIGVHVQFEQELNMEPYCCKDSGNLPHpqHFLYQLSAVVM 632
           ***999999999999999***********************997.8889********************888776555889******** PP
   S: 286  HsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           H+G +++sGHY+a+++n++g+ W++++Dsk +++  eev++   ++aY+lfY++
   Q: 633  HHGkGFGSGHYTAFCYNTEGGfWVHCNDSKLSVCAVEEVCK---AQAYILFYTQ 683
           *****************9999********************...********98 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALQHFKE 60
QHHPLALEVN ELYVYCYLCD DYVLNDNATG DLKLLRSTLS AIKSQCYEVT TRSGRTLRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGTCACGG AGGGACACTC CACGCGACAA GTGTGTAGAC AAGATGGCGC TTGCTGTTGT 60
GCCACAGAAG TAACCAGTGC TTGACGAAAA ATCAGGTTAG TAAAATATCA CCTTTTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	65.58	0.00e+00	896.00
IUUC-Apl-003673	Anas platyrhynchos	70.62	0.00e+00	927.00
IUUC-Aca-004434	Anolis carolinensis	69.12	0.00e+00	937.00
IUUC-Ame-010986	Astyanax mexicanus	86.80	0.00e+00	1113.00
IUUC-Bta-012774	Bos taurus	65.16	0.00e+00	889.00
IUUC-Cja-019619	Callithrix jacchus	65.16	0.00e+00	886.00
IUUC-Cfa-020957	Canis familiaris	64.68	0.00e+00	909.00
IUUC-Cpo-022233	Cavia porcellus	69.69	1.00e-167	583.00
IUUC-Csa-023177	Chlorocebus sabaeus	63.96	0.00e+00	884.00
IUUC-Cho-024877	Choloepus hoffmanni	60.40	3.00e-158	551.00
IUUC-Cin-025587	Ciona intestinalis	49.54	2.00e-111	397.00
IUUC-Csv-025814	Ciona savignyi	44.80	4.00e-151	528.00
IUUC-Dno-029832	Dasypus novemcinctus	65.11	0.00e+00	902.00
IUUC-Ete-032627	Echinops telfairi	63.97	0.00e+00	889.00
IUUC-Eca-033863	Equus caballus	64.29	0.00e+00	872.00
IUUC-Eeu-035225	Erinaceus europaeus	61.53	0.00e+00	832.00
IUUC-Fca-036288	Felis catus	65.44	0.00e+00	887.00
IUUC-Fal-037207	Ficedula albicollis	68.70	0.00e+00	902.00
IUUC-Gga-040457	Gallus gallus	70.48	0.00e+00	916.00
IUUC-Gac-042371	Gasterosteus aculeatus	74.38	6.00e-168	583.00
IUUC-Ggo-044926	Gorilla gorilla	64.59	0.00e+00	889.00
IUUC-Hsa-046079	Homo sapiens	64.14	0.00e+00	887.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	65.86	0.00e+00	896.00
IUUC-Lch-050260	Latimeria chalumnae	66.71	0.00e+00	861.00
IUUC-Loc-051981	Lepisosteus oculatus	72.77	0.00e+00	951.00
IUUC-Laf-054491	Loxodonta africana	64.45	0.00e+00	874.00
IUUC-Mcc-055694	Macaca mulatta	64.10	0.00e+00	885.00
IUUC-Meu-055971	Macropus eugenii	50.83	4.00e-111	395.00
IUUC-Mga-059523	Meleagris gallopavo	71.19	0.00e+00	927.00
IUUC-Mmr-060885	Microcebus murinus	65.07	0.00e+00	901.00
IUUC-Mdo-063018	Monodelphis domestica	68.58	0.00e+00	916.00
IUUC-Mmu-064012	Mus musculus	59.75	0.00e+00	819.00
IUUC-Mpu-066207	Mustela putorius furo	64.87	0.00e+00	905.00
IUUC-Mlu-066929	Myotis lucifugus	62.03	0.00e+00	845.00
IUUC-Nle-069486	Nomascus leucogenys	61.21	0.00e+00	787.00
IUUC-Opr-070375	Ochotona princeps	61.02	0.00e+00	818.00
IUUC-Ont-071637	Oreochromis niloticus	76.03	0.00e+00	962.00
IUUC-Oan-073030	Ornithorhynchus anatinus	66.61	0.00e+00	741.00
IUUC-Ocu-074836	Oryctolagus cuniculus	62.45	0.00e+00	863.00
IUUC-Oga-088367	Otolemur garnettii	65.63	0.00e+00	881.00
IUUC-Oar-089953	Ovis aries	64.87	0.00e+00	895.00
IUUC-Ptr-090980	Pan troglodytes	64.14	0.00e+00	890.00
IUUC-Pan-092748	Papio anubis	64.46	0.00e+00	892.00
IUUC-Psi-093353	Pelodiscus sinensis	62.92	0.00e+00	828.00
IUUC-Pfo-096860	Poecilia formosa	73.53	0.00e+00	949.00
IUUC-Pab-098514	Pongo abelii	65.30	0.00e+00	895.00
IUUC-Pca-100449	Procavia capensis	60.99	0.00e+00	789.00
IUUC-Pva-102984	Pteropus vampyrus	64.69	0.00e+00	905.00
IUUC-Rno-105190	Rattus norvegicus	61.07	0.00e+00	798.00
IUUC-Sha-106965	Sarcophilus harrisii	68.97	0.00e+00	910.00
IUUC-Ssc-115299	Sus scrofa	64.78	0.00e+00	900.00
IUUC-Tgu-117160	Taeniopygia guttata	68.23	0.00e+00	915.00
IUUC-Tru-118156	Takifugu rubripes	75.36	0.00e+00	954.00
IUUC-Tsy-118814	Tarsius syrichta	61.07	0.00e+00	781.00
IUUC-Tni-119733	Tetraodon nigroviridis	71.43	0.00e+00	952.00
IUUC-Tbe-128084	Tupaia belangeri	61.99	0.00e+00	856.00
IUUC-Ttr-128928	Tursiops truncatus	65.49	0.00e+00	898.00
IUUC-Vpa-130706	Vicugna pacos	64.50	0.00e+00	897.00
IUUC-Xtr-132061	Xenopus tropicalis	69.64	0.00e+00	887.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence