iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090855

UUCD1 version

UUC-PaT-00285

Ensembl Protein ID

ENSPTRP00000012898.2

UniProt Accession

H2QA80; H2QA80_PANTR

Genbank Protein ID

JAA05178.1; JAA20381.1; JAA31189.1; JAA44440.1

Protein Name

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Genbank Nucleotide ID

AACZ03105828; GABF01001764; GABD01001911; GABE01000299

Gene Name

STUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000007553.2	ENSPTRT00000013925.2	ENSPTRP00000012898.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.50e-27	93.0	226	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p+++++ Is+elMr+P+++psGitydr+ Ie++l++ g+ +Pvtr+plt+e+l+Pnl+++++i+a+++en++
   Q: 226  DIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGW 299
           69********************************************************************9986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA 60
VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTTGCGG GAACGCGCCC TCAGCGAAGC AAGTGAGGCA TCTCACTGGG AAAGTCGAAT 60
GTGTGTGGCG GCCGCCGCCG AGGCCGGTTC CGAAGAGACC TCAGCAGGGC AGGCCAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0016874--F:ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071218--P:cellular response to misfolded protein
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0032091--P:negative regulation of protein binding
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0031647--P:regulation of protein stability
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	35.50	2.00e-38	152.00
IUUC-Aml-001350	Ailuropoda melanoleuca	97.20	7.00e-141	492.00
IUUC-Atr-003168	Amborella trichopoda	34.91	1.00e-29	123.00
IUUC-Apl-003736	Anas platyrhynchos	87.65	2.00e-127	447.00
IUUC-Aca-004751	Anolis carolinensis	85.21	9.00e-138	482.00
IUUC-Aly-006292	Arabidopsis lyrata	34.41	2.00e-44	172.00
IUUC-Ath-007012	Arabidopsis thaliana	33.69	3.00e-41	161.00
IUUC-Acl-008025	Aspergillus clavatus	32.52	2.00e-33	135.00
IUUC-Afl-008721	Aspergillus flavus	31.47	9.00e-31	127.00
IUUC-Afu-008853	Aspergillus fumigatus	32.52	5.00e-33	134.00
IUUC-Ani-009349	Aspergillus nidulans	31.27	3.00e-32	132.00
IUUC-Ang-009674	Aspergillus niger	33.33	7.00e-30	124.00
IUUC-Aor-010014	Aspergillus oryzae	29.81	3.00e-25	108.00
IUUC-Ate-010467	Aspergillus terreus	30.64	6.00e-27	114.00
IUUC-Ame-011215	Astyanax mexicanus	59.79	3.00e-87	314.00
IUUC-Bgr-011971	Blumeria graminis	29.39	7.00e-25	107.00
IUUC-Bta-013025	Bos taurus	97.34	3.00e-164	570.00
IUUC-Bci-013945	Botrytis cinerea	39.51	5.00e-15	74.70
IUUC-Bdi-014483	Brachypodium distachyon	38.04	1.00e-44	173.00
IUUC-Bol-015676	Brassica oleracea	35.34	2.00e-45	176.00
IUUC-Bra-017897	Brassica rapa	32.54	1.00e-28	119.00
IUUC-Cel-018323	Caenorhabditis elegans	40.79	1.00e-54	206.00
IUUC-Cja-019657	Callithrix jacchus	98.95	8.00e-170	588.00
IUUC-Cfa-020470	Canis familiaris	97.40	9.00e-129	452.00
IUUC-Cpo-022033	Cavia porcellus	97.36	7.00e-166	575.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	27.59	8.00e-28	117.00
IUUC-Csa-023038	Chlorocebus sabaeus	100.00	2.00e-162	564.00
IUUC-Cin-025381	Ciona intestinalis	52.67	3.00e-85	308.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.26	4.00e-38	151.00
IUUC-Dre-027610	Danio rerio	77.24	2.00e-132	464.00
IUUC-Dno-030087	Dasypus novemcinctus	95.71	2.00e-163	568.00
IUUC-Dor-031029	Dipodomys ordii	92.63	9.00e-152	529.00
IUUC-Dse-031275	Dothistroma septosporum	31.85	9.00e-26	110.00
IUUC-Dme-031856	Drosophila melanogaster	57.71	3.00e-93	334.00
IUUC-Ete-033087	Echinops telfairi	92.65	8.00e-134	469.00
IUUC-Eca-033512	Equus caballus	97.60	4.00e-141	493.00
IUUC-Eeu-034763	Erinaceus europaeus	90.76	4.00e-92	329.00
IUUC-Fca-036460	Felis catus	97.79	2.00e-155	540.00
IUUC-Fal-037441	Ficedula albicollis	87.76	3.00e-145	507.00
IUUC-Fox-038028	Fusarium oxysporum	30.72	3.00e-36	145.00
IUUC-Fso-038323	Fusarium solani	31.91	6.00e-28	117.00
IUUC-Gmo-038511	Gadus morhua	77.19	6.00e-127	446.00
IUUC-Ggr-039964	Gaeumannomyces graminis	33.68	4.00e-25	108.00
IUUC-Gga-040854	Gallus gallus	88.11	7.00e-145	506.00
IUUC-Gac-042175	Gasterosteus aculeatus	73.79	7.00e-123	432.00
IUUC-Gma-044046	Glycine max	35.14	3.00e-42	165.00
IUUC-Ggo-044512	Gorilla gorilla	100.00	2.00e-162	564.00
IUUC-Hsa-046872	Homo sapiens	100.00	2.00e-162	564.00
IUUC-Hvu-047661	Hordeum vulgare	34.40	4.00e-39	154.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	98.60	2.00e-168	584.00
IUUC-Lch-049988	Latimeria chalumnae	79.37	1.00e-132	465.00
IUUC-Lpe-050693	Leersia perrieri	34.42	2.00e-42	166.00
IUUC-Loc-052195	Lepisosteus oculatus	78.04	4.00e-113	400.00
IUUC-Lma-053207	Leptosphaeria maculans	30.62	6.00e-28	119.00
IUUC-Laf-054584	Loxodonta africana	95.38	2.00e-163	568.00
IUUC-Mcc-054689	Macaca mulatta	100.00	2.00e-162	564.00
IUUC-Meu-055998	Macropus eugenii	88.95	1.00e-81	296.00
IUUC-Mor-057116	Magnaporthe oryzae	34.39	4.00e-40	158.00
IUUC-Mtr-057684	Medicago truncatula	32.14	4.00e-38	151.00
IUUC-Mga-059332	Meleagris gallopavo	88.05	3.00e-127	447.00
IUUC-Mmr-061377	Microcebus murinus	98.60	3.00e-160	557.00
IUUC-Mdo-061963	Monodelphis domestica	91.26	9.00e-147	512.00
IUUC-Mmu-063146	Mus musculus	97.37	5.00e-161	559.00
IUUC-Mac-064932	Musa acuminata	34.63	9.00e-28	116.00
IUUC-Mpu-066418	Mustela putorius furo	97.54	2.00e-162	564.00
IUUC-Mlu-067066	Myotis lucifugus	97.36	1.00e-165	575.00
IUUC-Nfi-068601	Neosartorya fischeri	32.52	1.00e-32	133.00
IUUC-Ncr-068761	Neurospora crassa	41.67	3.00e-17	82.00
IUUC-Nle-069374	Nomascus leucogenys	100.00	2.00e-162	564.00
IUUC-Opr-070765	Ochotona princeps	93.44	1.00e-97	348.00
IUUC-Ont-071996	Oreochromis niloticus	79.65	2.00e-130	458.00
IUUC-Oba-075967	Oryza barthii	35.74	1.00e-43	169.00
IUUC-Obr-076440	Oryza brachyantha	33.91	9.00e-30	126.00
IUUC-Ogl-077495	Oryza glaberrima	35.74	1.00e-43	169.00
IUUC-Ogu-078247	Oryza glumaepatula	35.57	3.00e-39	155.00
IUUC-Oin-079376	Oryza indica	35.74	1.00e-43	169.00
IUUC-Olo-081083	Oryza longistaminata	31.52	2.00e-30	125.00
IUUC-Ome-081935	Oryza meridionalis	28.30	4.00e-20	94.40
IUUC-Oni-082535	Oryza nivara	35.57	3.00e-39	155.00
IUUC-Opu-083794	Oryza punctata	35.74	5.00e-43	167.00
IUUC-Oru-085153	Oryza rufipogon	35.74	2.00e-43	168.00
IUUC-Osa-085936	Oryza sativa	35.82	1.00e-16	79.30
IUUC-Ola-087081	Oryzias latipes	77.89	1.00e-129	455.00
IUUC-Olu-087790	Ostreococcus lucimarinus	31.90	1.00e-31	129.00
IUUC-Oga-088331	Otolemur garnettii	98.35	8.00e-165	572.00
IUUC-Oar-089987	Ovis aries	92.97	7.00e-137	479.00
IUUC-Pan-092801	Papio anubis	94.39	4.00e-157	546.00
IUUC-Psi-093393	Pelodiscus sinensis	86.85	4.00e-126	443.00
IUUC-Pma-094680	Petromyzon marinus	68.93	4.00e-110	390.00
IUUC-Pno-094913	Phaeosphaeria nodorum	31.88	1.00e-32	133.00
IUUC-Ppa-095508	Physcomitrella patens	32.50	1.00e-41	163.00
IUUC-Pfo-096850	Poecilia formosa	77.54	4.00e-127	447.00
IUUC-Pab-097963	Pongo abelii	100.00	2.00e-162	564.00
IUUC-Pop-098805	Populus trichocarpa	42.86	8.00e-25	106.00
IUUC-Pca-100788	Procavia capensis	96.37	2.00e-165	573.00
IUUC-Ppe-101221	Prunus persica	33.45	3.00e-43	168.00
IUUC-Pva-103076	Pteropus vampyrus	96.04	7.00e-165	572.00
IUUC-Pte-104237	Pyrenophora teres	31.82	7.00e-33	134.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	31.82	6.00e-33	134.00
IUUC-Rno-105204	Rattus norvegicus	97.37	2.00e-161	560.00
IUUC-Sha-106579	Sarcophilus harrisii	86.33	2.00e-126	444.00
IUUC-Smo-109525	Selaginella moellendorffii	35.77	2.00e-41	162.00
IUUC-Sit-110665	Setaria italica	35.36	1.00e-42	166.00
IUUC-Sly-111473	Solanum lycopersicum	35.59	8.00e-44	170.00
IUUC-Stu-112353	Solanum tuberosum	34.98	3.00e-42	165.00
IUUC-Sbi-114250	Sorghum bicolor	36.59	2.00e-44	172.00
IUUC-Ssc-115416	Sus scrofa	96.70	7.00e-165	572.00
IUUC-Tgu-117272	Taeniopygia guttata	93.52	6.00e-57	211.00
IUUC-Tru-117777	Takifugu rubripes	78.60	7.00e-129	452.00
IUUC-Tni-120572	Tetraodon nigroviridis	80.00	5.00e-130	456.00
IUUC-Tca-121149	Theobroma cacao	37.55	1.00e-47	182.00
IUUC-Tre-122230	Trichoderma reesei	33.21	2.00e-32	132.00
IUUC-Tvi-122678	Trichoderma virens	35.61	6.00e-41	160.00
IUUC-Tae-122986	Triticum aestivum	34.40	5.00e-42	164.00
IUUC-Tur-126009	Triticum urartu	34.23	1.00e-37	149.00
IUUC-Tme-126948	Tuber melanosporum	35.48	3.00e-41	161.00
IUUC-Ttr-129031	Tursiops truncatus	94.39	7.00e-163	565.00
IUUC-Vda-130023	Verticillium dahliae	32.97	1.00e-37	149.00
IUUC-Vvi-131091	Vitis vinifera	49.44	1.00e-25	108.00
IUUC-Xtr-132871	Xenopus tropicalis	82.86	4.00e-129	453.00
IUUC-Xma-134220	Xiphophorus maculatus	77.89	2.00e-127	448.00
IUUC-Yli-134462	Yarrowia lipolytica	27.92	2.00e-28	119.00
IUUC-Zma-135773	Zea mays	35.61	5.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence