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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046756
UUCD1 version UUC-HoS-00996
Ensembl Protein ID ENSP00000489389.1
UniProt Accession Q9P2D0; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9Y3T8; IBTK_HUMAN
Genbank Protein ID AAY55906.1; AAY55907.1; AAY55908.1; BAA92655.2; CAI23414.1; CAI23416.1; AAH27490.1; AAH38244.2; AAH42171.2; AAI13697.1; AAI13699.1; CAB43239.1; AAG27170.1
Protein Name Inhibitor of Bruton tyrosine kinase
Genbank Nucleotide ID DQ005633; DQ005634; DQ005635; AB037838; AL050333; AL050333; BC027490; BC038244; BC042171; BC113696; BC113698; AL050018; AF235049
Gene Name IBTK; BTKI; KIAA1417
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000283068.1 ENST00000635454.1 ENSP00000489389.1
ENSG00000283068.1 ENST00000635314.1 ENSP00000489552.1
ENSG00000283068.1 ENST00000634585.1 ENSP00000489043.1
ENSG00000283068.1 ENST00000635384.1 ENSP00000489548.1
ENSG00000283068.1 ENST00000634571.1 ENSP00000488952.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
TCGAICGCCOSMICTHPA
HPM
DNA & RNA Element
UTRdbcircRNADbCircNetRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.20e-25 90.4 565 641
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmelees.............ksklmveikdvqpevfrallkFlYtgkld 66
           Dv+++vg++ f+ahk++La +S++F++lfl++ + s                   +++ v p+ f+ ll+F+Yt++ d
   Q: 565  DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSeftdiyqkdedsaG-CHLFVVEKVHPDMFEYLLQFIYTDTCD 641
           9****************************9999988899*****996532.23344445***************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
 Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Protein Sequence
(Fasta)
MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 60
SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046756|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCCTCTAC ATCCCCGTTC CCGATTCCTG TAGTAGCGGC TGTATTGCAG CCGCCTGCCG 60
AACTGACCCG GGTCTGGGGA CTGGCCCCTC TGGCGCCGTT CGGTTTCTCT TATTGCCTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046756|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR011333--SKP1/BTB/POZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
PS50012--RCC1_3
Pfam

PF12796--Ank_2
PF00651--BTB
PF00415--RCC1
SMART

SM00248--ANK
SM00225--BTB
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0019901--F:protein kinase binding
GO:0030292--F:protein tyrosine kinase inhibitor activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:0051209--P:release of sequestered calcium ion into cytosol
KEGG hsa:25998
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000696 Aegilops tauschii 31.35 3.00e-40 161.00
IUUC-Aml-001765 Ailuropoda melanoleuca 90.71 0.00e+00 2385.00
IUUC-Atr-003012 Amborella trichopoda 31.46 1.00e-32 135.00
IUUC-Apl-003868 Anas platyrhynchos 72.15 0.00e+00 1944.00
IUUC-Aca-004897 Anolis carolinensis 66.99 0.00e+00 1709.00
IUUC-Aly-005989 Arabidopsis lyrata 30.28 3.00e-36 147.00
IUUC-Ath-007268 Arabidopsis thaliana 30.73 1.00e-35 145.00
IUUC-Ago-007942 Ashbya gossypii 24.78 5.00e-11 63.90
IUUC-Acl-008353 Aspergillus clavatus 27.01 4.00e-32 134.00
IUUC-Afl-008409 Aspergillus flavus 26.28 3.00e-36 148.00
IUUC-Afu-008944 Aspergillus fumigatus 25.30 2.00e-33 138.00
IUUC-Ani-009309 Aspergillus nidulans 25.55 2.00e-31 132.00
IUUC-Ang-009872 Aspergillus niger 28.48 9.00e-38 153.00
IUUC-Aor-010054 Aspergillus oryzae 26.28 3.00e-36 148.00
IUUC-Ate-010319 Aspergillus terreus 21.99 3.00e-12 68.60
IUUC-Ame-010972 Astyanax mexicanus 57.09 0.00e+00 1423.00
IUUC-Bgr-012036 Blumeria graminis 26.14 2.00e-29 125.00
IUUC-Bta-012491 Bos taurus 90.32 0.00e+00 2388.00
IUUC-Bci-013874 Botrytis cinerea 25.77 9.00e-34 139.00
IUUC-Bdi-014094 Brachypodium distachyon 30.52 5.00e-41 163.00
IUUC-Bol-015876 Brassica oleracea 30.23 2.00e-32 134.00
IUUC-Bra-017155 Brassica rapa 30.23 1.00e-34 142.00
IUUC-Cja-019928 Callithrix jacchus 94.83 0.00e+00 2503.00
IUUC-Cfa-021191 Canis familiaris 91.06 0.00e+00 2446.00
IUUC-Cpo-021893 Cavia porcellus 86.22 0.00e+00 1470.00
IUUC-Csa-023410 Chlorocebus sabaeus 98.08 0.00e+00 2628.00
IUUC-Cho-024939 Choloepus hoffmanni 82.11 0.00e+00 1925.00
IUUC-Cin-025713 Ciona intestinalis 33.71 2.00e-139 490.00
IUUC-Cgl-026577 Colletotrichum gloeosporioides 23.64 4.00e-15 78.20
IUUC-Cne-026961 Cryptococcus neoformans 31.33 2.00e-21 99.00
IUUC-Cme-027274 Cyanidioschyzon merolae 30.62 1.00e-11 66.20
IUUC-Dre-027465 Danio rerio 54.80 0.00e+00 1372.00
IUUC-Dno-029885 Dasypus novemcinctus 90.55 0.00e+00 2408.00
IUUC-Dor-030105 Dipodomys ordii 87.22 0.00e+00 924.00
IUUC-Dse-031213 Dothistroma septosporum 26.79 1.00e-37 152.00
IUUC-Dme-031915 Drosophila melanogaster 28.89 8.00e-59 222.00
IUUC-Ete-033002 Echinops telfairi 75.30 0.00e+00 1895.00
IUUC-Eca-034271 Equus caballus 91.72 0.00e+00 2451.00
IUUC-Eeu-034921 Erinaceus europaeus 82.47 0.00e+00 2145.00
IUUC-Fca-036135 Felis catus 89.04 0.00e+00 2415.00
IUUC-Fal-036815 Ficedula albicollis 72.28 0.00e+00 1840.00
IUUC-Fox-037821 Fusarium oxysporum 25.07 3.00e-19 92.00
IUUC-Fso-038316 Fusarium solani 26.61 1.00e-21 99.80
IUUC-Gmo-038841 Gadus morhua 55.53 0.00e+00 1369.00
IUUC-Ggr-040105 Gaeumannomyces graminis 27.15 1.00e-20 96.30
IUUC-Gga-040756 Gallus gallus 72.13 0.00e+00 1872.00
IUUC-Gac-041957 Gasterosteus aculeatus 57.62 0.00e+00 1435.00
IUUC-Gma-043801 Glycine max 30.59 4.00e-41 163.00
IUUC-Ggo-044737 Gorilla gorilla 96.01 0.00e+00 2528.00
IUUC-Itr-048204 Ictidomys tridecemlineatus 92.39 0.00e+00 2436.00
IUUC-Lch-050082 Latimeria chalumnae 75.14 7.00e-81 292.00
IUUC-Lpe-050709 Leersia perrieri 31.72 1.00e-42 169.00
IUUC-Loc-052669 Lepisosteus oculatus 62.51 0.00e+00 1615.00
IUUC-Lma-053227 Leptosphaeria maculans 27.48 3.00e-38 155.00
IUUC-Laf-053898 Loxodonta africana 90.25 0.00e+00 2368.00
IUUC-Mcc-055614 Macaca mulatta 97.86 0.00e+00 2597.00
IUUC-Meu-056803 Macropus eugenii 54.97 0.00e+00 1135.00
IUUC-Mor-056973 Magnaporthe oryzae 22.49 4.00e-38 154.00
IUUC-Mpo-057627 Magnaporthe poae 21.79 4.00e-29 124.00
IUUC-Mtr-058718 Medicago truncatula 31.35 4.00e-41 164.00
IUUC-Mla-058948 Melampsora laricipopulina 28.71 8.00e-30 127.00
IUUC-Mga-059344 Meleagris gallopavo 71.28 0.00e+00 1833.00
IUUC-Mvi-060265 Microbotryum violaceum 26.49 8.00e-29 123.00
IUUC-Mmr-061025 Microcebus murinus 92.68 0.00e+00 2447.00
IUUC-Mdo-061884 Monodelphis domestica 78.10 0.00e+00 2051.00
IUUC-Mmu-063492 Mus musculus 85.82 0.00e+00 2237.00
IUUC-Mac-065442 Musa acuminata 29.40 1.00e-38 155.00
IUUC-Mpu-065714 Mustela putorius furo 89.88 0.00e+00 2396.00
IUUC-Mlu-068229 Myotis lucifugus 88.49 0.00e+00 2319.00
IUUC-Nfi-068585 Neosartorya fischeri 25.71 1.00e-34 142.00
IUUC-Ncr-068789 Neurospora crassa 28.68 2.00e-18 89.40
IUUC-Nle-070017 Nomascus leucogenys 98.89 0.00e+00 2621.00
IUUC-Opr-070430 Ochotona princeps 75.46 0.00e+00 1936.00
IUUC-Ont-071686 Oreochromis niloticus 58.69 0.00e+00 1483.00
IUUC-Oan-073539 Ornithorhynchus anatinus 75.64 0.00e+00 1845.00
IUUC-Ocu-074076 Oryctolagus cuniculus 90.99 0.00e+00 2392.00
IUUC-Oba-075204 Oryza barthii 31.73 4.00e-43 170.00
IUUC-Obr-076797 Oryza brachyantha 32.90 5.00e-42 166.00
IUUC-Ogl-077619 Oryza glaberrima 32.15 4.00e-44 173.00
IUUC-Ogu-078961 Oryza glumaepatula 31.94 2.00e-43 171.00
IUUC-Oin-079261 Oryza indica 31.94 2.00e-43 171.00
IUUC-Olo-080829 Oryza longistaminata 31.94 1.00e-43 172.00
IUUC-Ome-081599 Oryza meridionalis 31.73 3.00e-43 171.00
IUUC-Oni-082029 Oryza nivara 31.94 6.00e-43 169.00
IUUC-Opu-083657 Oryza punctata 32.29 9.00e-43 169.00
IUUC-Oru-084765 Oryza rufipogon 31.94 2.00e-43 171.00
IUUC-Osa-086136 Oryza sativa 31.94 1.00e-42 168.00
IUUC-Ola-087419 Oryzias latipes 59.71 0.00e+00 1510.00
IUUC-Oga-088885 Otolemur garnettii 88.54 0.00e+00 2327.00
IUUC-Oar-090361 Ovis aries 89.59 0.00e+00 2365.00
IUUC-Ptr-091424 Pan troglodytes 99.41 0.00e+00 2640.00
IUUC-Pan-092557 Papio anubis 96.75 0.00e+00 2569.00
IUUC-Psi-093980 Pelodiscus sinensis 73.20 0.00e+00 1923.00
IUUC-Pno-094989 Phaeosphaeria nodorum 28.66 2.00e-32 135.00
IUUC-Ppa-095929 Physcomitrella patens 33.53 4.00e-41 163.00
IUUC-Pfo-096296 Poecilia formosa 55.88 0.00e+00 1422.00
IUUC-Pab-097552 Pongo abelii 99.26 0.00e+00 2635.00
IUUC-Pop-099124 Populus trichocarpa 30.32 1.00e-41 165.00
IUUC-Pca-100417 Procavia capensis 84.79 0.00e+00 931.00
IUUC-Ppe-101574 Prunus persica 35.71 4.00e-38 154.00
IUUC-Pva-102906 Pteropus vampyrus 85.96 0.00e+00 2251.00
IUUC-Pgr-103405 Puccinia graminis 28.30 7.00e-32 134.00
IUUC-Ptt-103743 Puccinia triticina 29.41 4.00e-36 147.00
IUUC-Pte-104407 Pyrenophora teres 27.07 4.00e-39 157.00
IUUC-Pyt-104646 Pyrenophora triticirepentis 27.07 4.00e-39 157.00
IUUC-Rno-105118 Rattus norvegicus 83.83 0.00e+00 2173.00
IUUC-Sha-106797 Sarcophilus harrisii 77.31 0.00e+00 1994.00
IUUC-Sja-107740 Schizosaccharomyces japonicus 28.80 4.00e-42 167.00
IUUC-Spo-108090 Schizosaccharomyces pombe 32.87 6.00e-39 157.00
IUUC-Ssl-108513 Sclerotinia sclerotiorum 24.56 1.00e-27 119.00
IUUC-Smo-109576 Selaginella moellendorffii 33.80 1.00e-37 152.00
IUUC-Sit-110676 Setaria italica 31.17 3.00e-42 167.00
IUUC-Sly-111572 Solanum lycopersicum 28.87 2.00e-30 128.00
IUUC-Sar-113437 Sorex araneus 80.06 0.00e+00 2039.00
IUUC-Sbi-114124 Sorghum bicolor 30.99 3.00e-40 160.00
IUUC-Sre-114999 Sporisorium reilianum 28.61 1.00e-33 140.00
IUUC-Ssc-116088 Sus scrofa 90.47 0.00e+00 2305.00
IUUC-Tgu-116854 Taeniopygia guttata 72.37 0.00e+00 1886.00
IUUC-Tru-117552 Takifugu rubripes 56.74 0.00e+00 1422.00
IUUC-Tsy-118821 Tarsius syrichta 86.84 0.00e+00 2025.00
IUUC-Tni-119891 Tetraodon nigroviridis 57.02 0.00e+00 1433.00
IUUC-Tca-121015 Theobroma cacao 29.63 1.00e-38 155.00
IUUC-Tre-122202 Trichoderma reesei 26.17 4.00e-23 104.00
IUUC-Tvi-122439 Trichoderma virens 26.36 2.00e-22 102.00
IUUC-Tae-123606 Triticum aestivum 31.86 3.00e-41 164.00
IUUC-Tur-126077 Triticum urartu 31.82 2.00e-39 158.00
IUUC-Tme-127029 Tuber melanosporum 29.27 2.00e-28 122.00
IUUC-Tbe-127811 Tupaia belangeri 77.91 0.00e+00 1208.00
IUUC-Ttr-128664 Tursiops truncatus 85.87 0.00e+00 2029.00
IUUC-Uma-129427 Ustilago maydis 28.75 3.00e-32 135.00
IUUC-Vda-129791 Verticillium dahliae 26.32 6.00e-22 100.00
IUUC-Vpa-130558 Vicugna pacos 84.04 0.00e+00 2149.00
IUUC-Vvi-131602 Vitis vinifera 34.84 1.00e-37 152.00
IUUC-Xtr-131965 Xenopus tropicalis 62.79 0.00e+00 1554.00
IUUC-Xma-133569 Xiphophorus maculatus 56.04 0.00e+00 1430.00
IUUC-Yli-134409 Yarrowia lipolytica 31.18 2.00e-26 115.00
IUUC-Zma-135450 Zea mays 30.72 4.00e-42 167.00
Created Date 25-Jun-2017

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