iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004990

Ensembl Protein ID

ENSACAP00000006812.3

UniProt Accession

G1KFY5; G1KFY5_ANOCA

Protein Name

Inhibitor of growth protein

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000006973.3	ENSACAT00000006962.3	ENSACAP00000006812.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.50e-09	36.7	252	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C++ + +e  ++ C++  Cr ewfH+ C++l+    +p+ + w+CpkCr
   Q: 252  TYC-LCDQVSYGE--MIGCDNelCRiEWFHFSCVGLT---YKPKGK-WYCPKCR 298
           69*.*******99..**********************...888886.******8 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MMLGSPGQQP GGAGSGAAVS PAAASAGSGS ANAAGGGFGG VAGFPCGGGG GGGGGGGGSE 60
RFLARYVQDY LECVESLPLD MQRLASLLRE MDTRCREALK EIDEVYEKYK SEEDLAQKKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAAAGCCC CGCCTCCTAT CCCATCCCAG TCCCTCCTCC CTGTTTGTCT TCCGACGTCA 60
CACCCTTCAG AGCCAATGGC GTCGCCCTGG CGGGGAAGGC GGGAGAATGC GAACGAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

KEGG

acs:100560186

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	81.47	3.00e-89	321.00
IUUC-Apl-003705	Anas platyrhynchos	89.24	1.00e-91	328.00
IUUC-Ame-011426	Astyanax mexicanus	67.16	3.00e-75	274.00
IUUC-Bta-012721	Bos taurus	80.69	1.00e-88	318.00
IUUC-Cja-018960	Callithrix jacchus	81.08	4.00e-81	294.00
IUUC-Cfa-020869	Canis familiaris	81.47	5.00e-89	320.00
IUUC-Cpo-021414	Cavia porcellus	79.92	2.00e-87	315.00
IUUC-Csa-023304	Chlorocebus sabaeus	81.47	1.00e-81	295.00
IUUC-Dre-028562	Danio rerio	70.90	3.00e-84	304.00
IUUC-Dno-029945	Dasypus novemcinctus	81.47	5.00e-90	323.00
IUUC-Dor-030141	Dipodomys ordii	80.69	2.00e-86	311.00
IUUC-Ete-032709	Echinops telfairi	81.08	4.00e-98	350.00
IUUC-Eca-033432	Equus caballus	81.08	2.00e-88	318.00
IUUC-Eeu-035285	Erinaceus europaeus	85.22	2.00e-76	277.00
IUUC-Fca-036467	Felis catus	81.08	1.00e-88	318.00
IUUC-Fal-036700	Ficedula albicollis	88.79	2.00e-91	327.00
IUUC-Gmo-038748	Gadus morhua	61.34	9.00e-82	296.00
IUUC-Gga-040175	Gallus gallus	89.24	4.00e-92	330.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.04	2.00e-85	308.00
IUUC-Hsa-045837	Homo sapiens	81.47	1.00e-81	295.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	80.31	7.00e-88	316.00
IUUC-Lch-049965	Latimeria chalumnae	77.04	2.00e-92	331.00
IUUC-Laf-053353	Loxodonta africana	83.41	2.00e-84	304.00
IUUC-Mcc-055155	Macaca mulatta	83.33	1.00e-59	221.00
IUUC-Meu-056470	Macropus eugenii	83.07	4.00e-97	347.00
IUUC-Mga-059570	Meleagris gallopavo	88.79	4.00e-91	327.00
IUUC-Mmr-061385	Microcebus murinus	81.08	4.00e-81	293.00
IUUC-Mdo-062144	Monodelphis domestica	83.46	2.00e-97	348.00
IUUC-Mmu-063215	Mus musculus	81.47	2.00e-89	321.00
IUUC-Mpu-065749	Mustela putorius furo	81.17	1.00e-79	289.00
IUUC-Mlu-067245	Myotis lucifugus	66.01	2.00e-70	257.00
IUUC-Nle-069968	Nomascus leucogenys	84.21	2.00e-68	251.00
IUUC-Ont-071524	Oreochromis niloticus	68.16	3.00e-84	304.00
IUUC-Ocu-074870	Oryctolagus cuniculus	81.08	5.00e-89	320.00
IUUC-Oga-088336	Otolemur garnettii	81.47	2.00e-81	295.00
IUUC-Oar-090136	Ovis aries	80.31	3.00e-88	317.00
IUUC-Ptr-091348	Pan troglodytes	84.21	9.00e-69	252.00
IUUC-Pan-092819	Papio anubis	81.47	1.00e-81	295.00
IUUC-Pfo-096633	Poecilia formosa	68.28	5.00e-78	283.00
IUUC-Pab-098346	Pongo abelii	81.47	2.00e-81	295.00
IUUC-Pca-100278	Procavia capensis	81.89	1.00e-96	345.00
IUUC-Pva-103190	Pteropus vampyrus	81.08	5.00e-89	320.00
IUUC-Rno-104940	Rattus norvegicus	80.31	4.00e-88	317.00
IUUC-Sha-107533	Sarcophilus harrisii	83.07	2.00e-96	344.00
IUUC-Sar-113630	Sorex araneus	84.73	1.00e-74	272.00
IUUC-Ssc-115734	Sus scrofa	81.08	5.00e-89	320.00
IUUC-Tgu-117034	Taeniopygia guttata	89.24	2.00e-91	328.00
IUUC-Tru-118168	Takifugu rubripes	58.96	3.00e-77	281.00
IUUC-Tsy-119494	Tarsius syrichta	83.68	3.00e-68	250.00
IUUC-Tni-120100	Tetraodon nigroviridis	62.10	3.00e-72	264.00
IUUC-Ttr-128442	Tursiops truncatus	84.24	1.00e-75	275.00
IUUC-Vpa-130063	Vicugna pacos	80.69	1.00e-88	318.00
IUUC-Xtr-132348	Xenopus tropicalis	71.21	3.00e-61	228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence