iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062771

UUCD1 version

UUC-MoD-00745

Ensembl Protein ID

ENSMODP00000016709.3

UniProt Accession

F7DTS8; F7DTS8_MONDO

Protein Name

Uncharacterized protein

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013364.4	ENSMODT00000017019.4	ENSMODP00000016709.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-08	35.6	349	387
UBD/Alpha-Helix/CUE	2.40e-11	43.5	464	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 349  CAICWDSMQS-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 387
           ********99.9*****************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 464  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 505
           5889*********************.***************95 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSLSE PGPSAGPGEP EALTSSQQPP 60
PPQPPPPSAP PGPGGPRARD VAQYLLSDSL FVWVLVNTAC CFLMLVAKLI QCVVFGPLRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGCTGC TCTTCCTGGA GCGCTTTCCC TGGCCCAGCC TCCGCACCTA CACGGGCCTC 60
AGCGGTCTGG CGCTGCTGGG CACCATCGTG AGTGCCTACC GCGCCCTCAG CTTGTCCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mdo:100015225

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	91.14	0.00e+00	995.00
IUUC-Apl-003404	Anas platyrhynchos	89.32	0.00e+00	960.00
IUUC-Aca-004559	Anolis carolinensis	85.28	0.00e+00	866.00
IUUC-Ame-011640	Astyanax mexicanus	71.45	0.00e+00	833.00
IUUC-Bta-012980	Bos taurus	83.72	0.00e+00	1035.00
IUUC-Cel-018598	Caenorhabditis elegans	25.52	3.00e-34	139.00
IUUC-Cja-019577	Callithrix jacchus	90.02	0.00e+00	1133.00
IUUC-Cfa-020793	Canis familiaris	91.43	0.00e+00	1002.00
IUUC-Cpo-022387	Cavia porcellus	89.86	0.00e+00	1095.00
IUUC-Csa-023168	Chlorocebus sabaeus	90.32	0.00e+00	1137.00
IUUC-Cho-024433	Choloepus hoffmanni	93.62	0.00e+00	832.00
IUUC-Cin-025215	Ciona intestinalis	43.97	2.00e-145	509.00
IUUC-Csv-026133	Ciona savignyi	49.71	9.00e-132	463.00
IUUC-Dre-027594	Danio rerio	68.51	0.00e+00	781.00
IUUC-Dno-029407	Dasypus novemcinctus	93.01	0.00e+00	994.00
IUUC-Dor-030961	Dipodomys ordii	93.73	0.00e+00	1023.00
IUUC-Ete-032962	Echinops telfairi	84.41	0.00e+00	841.00
IUUC-Eca-033683	Equus caballus	85.43	0.00e+00	1034.00
IUUC-Eeu-034515	Erinaceus europaeus	97.78	3.00e-79	288.00
IUUC-Fca-035398	Felis catus	93.75	0.00e+00	971.00
IUUC-Fal-036758	Ficedula albicollis	81.70	0.00e+00	892.00
IUUC-Gmo-039014	Gadus morhua	68.85	0.00e+00	765.00
IUUC-Gga-040575	Gallus gallus	84.02	0.00e+00	1034.00
IUUC-Gac-041414	Gasterosteus aculeatus	66.72	0.00e+00	746.00
IUUC-Hsa-046272	Homo sapiens	90.02	0.00e+00	1127.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	92.17	0.00e+00	986.00
IUUC-Lch-050491	Latimeria chalumnae	75.16	0.00e+00	878.00
IUUC-Loc-052758	Lepisosteus oculatus	72.06	0.00e+00	852.00
IUUC-Laf-053452	Loxodonta africana	92.86	0.00e+00	995.00
IUUC-Mcc-055820	Macaca mulatta	92.88	0.00e+00	1009.00
IUUC-Meu-056726	Macropus eugenii	88.35	0.00e+00	892.00
IUUC-Mga-059937	Meleagris gallopavo	87.80	0.00e+00	957.00
IUUC-Mmr-060730	Microcebus murinus	87.10	0.00e+00	1077.00
IUUC-Mmu-064219	Mus musculus	89.38	0.00e+00	1118.00
IUUC-Mpu-066796	Mustela putorius furo	92.70	0.00e+00	1006.00
IUUC-Mlu-068189	Myotis lucifugus	91.08	0.00e+00	995.00
IUUC-Nle-069239	Nomascus leucogenys	89.79	0.00e+00	1081.00
IUUC-Opr-070702	Ochotona princeps	84.78	2.00e-137	483.00
IUUC-Ont-072033	Oreochromis niloticus	69.37	0.00e+00	819.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.08	0.00e+00	872.00
IUUC-Ocu-074145	Oryctolagus cuniculus	89.25	0.00e+00	1124.00
IUUC-Ogl-077929	Oryza glaberrima	51.16	2.00e-11	61.60
IUUC-Ola-087152	Oryzias latipes	67.90	0.00e+00	786.00
IUUC-Oga-088486	Otolemur garnettii	93.07	0.00e+00	997.00
IUUC-Oar-089310	Ovis aries	91.61	0.00e+00	1017.00
IUUC-Ptr-090649	Pan troglodytes	92.47	0.00e+00	1023.00
IUUC-Pan-091692	Papio anubis	86.02	0.00e+00	1062.00
IUUC-Psi-093064	Pelodiscus sinensis	95.23	0.00e+00	782.00
IUUC-Pma-094763	Petromyzon marinus	77.46	5.00e-97	347.00
IUUC-Ppa-095969	Physcomitrella patens	30.25	1.00e-37	151.00
IUUC-Pfo-096810	Poecilia formosa	70.13	0.00e+00	803.00
IUUC-Pab-097859	Pongo abelii	92.70	0.00e+00	1008.00
IUUC-Pca-100344	Procavia capensis	85.03	0.00e+00	1044.00
IUUC-Pva-103114	Pteropus vampyrus	65.75	0.00e+00	706.00
IUUC-Rno-105880	Rattus norvegicus	87.52	0.00e+00	1060.00
IUUC-Sha-107015	Sarcophilus harrisii	96.77	0.00e+00	1042.00
IUUC-Smo-109664	Selaginella moellendorffii	30.41	2.00e-32	134.00
IUUC-Sar-113397	Sorex araneus	97.04	0.00e+00	758.00
IUUC-Ssc-115988	Sus scrofa	86.46	7.00e-137	479.00
IUUC-Tgu-116717	Taeniopygia guttata	89.22	0.00e+00	950.00
IUUC-Tru-117805	Takifugu rubripes	68.14	0.00e+00	819.00
IUUC-Tsy-119442	Tarsius syrichta	86.56	0.00e+00	920.00
IUUC-Tni-119777	Tetraodon nigroviridis	71.82	3.00e-174	604.00
IUUC-Tbe-127322	Tupaia belangeri	67.47	3.00e-113	402.00
IUUC-Ttr-128181	Tursiops truncatus	91.58	0.00e+00	1017.00
IUUC-Vpa-130483	Vicugna pacos	84.52	0.00e+00	656.00
IUUC-Xtr-132614	Xenopus tropicalis	74.12	0.00e+00	802.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence