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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063754
UUCD1 version UUC-MuM-00610
Ensembl Protein ID ENSMUSP00000034239.7
UniProt Accession Q8BG40; Q8CD18; Q8R1J0; Q9CWV2; KTNB1_MOUSE
Genbank Protein ID BAB26884.1; BAC27487.1; BAC28588.1; BAC33697.1; BAC40067.1; AAH24500.1; AAH45200.1
Protein Name Katanin p80 WD40 repeat-containing subunit B1; p80 katanin
Genbank Nucleotide ID AK010364; AK031630; AK034103; AK049345; AK087973; BC024500; BC045200
Gene Name Katnb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031787.8 ENSMUST00000034239.8 ENSMUSP00000034239.7
ENSMUSG00000031787.8 ENSMUST00000212968.1 ENSMUSP00000148781.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.70e-45 151.0 145 180
UBD/Beta-Prp 7.80e-60 203.7 15 258
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 258
           ***********************************************************766.556544 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
 Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Protein Sequence
(Fasta)
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063754|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCCGGAGG TTTTGTTGTG AGGGTCGGTT GTCAAGCAGC GACCAATCAG GGCAAAGGAT 60
GGAGGCAAGT GGGGGTCGCG CCTGGAGGGA AGCCTTGGCC TCCAGAGCTA CAGCTGCAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063754|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF13925--Katanin_con80
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030426--C:growth cone
GO:0008352--C:katanin complex
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0070840--F:dynein complex binding
GO:0008568--F:microtubule-severing ATPase activity
GO:0046982--F:protein heterodimerization activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0010942--P:positive regulation of cell death
GO:0031117--P:positive regulation of microtubule depolymerization
GO:0010976--P:positive regulation of neuron projection development
KEGG mmu:74187
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000954 Aegilops tauschii 48.10 1.00e-84 308.00
IUUC-Aml-002187 Ailuropoda melanoleuca 87.41 0.00e+00 1065.00
IUUC-Atr-002899 Amborella trichopoda 54.33 2.00e-101 363.00
IUUC-Apl-003305 Anas platyrhynchos 77.29 0.00e+00 992.00
IUUC-Aca-004635 Anolis carolinensis 80.21 0.00e+00 951.00
IUUC-Aly-005711 Arabidopsis lyrata 51.68 9.00e-101 361.00
IUUC-Ath-007606 Arabidopsis thaliana 51.68 9.00e-101 361.00
IUUC-Ame-010870 Astyanax mexicanus 56.04 2.00e-94 339.00
IUUC-Bta-012527 Bos taurus 93.09 0.00e+00 1151.00
IUUC-Bdi-014652 Brachypodium distachyon 53.38 1.00e-102 367.00
IUUC-Bol-015242 Brassica oleracea 50.67 6.00e-99 355.00
IUUC-Bra-017390 Brassica rapa 51.01 2.00e-99 357.00
IUUC-Cja-019706 Callithrix jacchus 93.64 0.00e+00 1072.00
IUUC-Cfa-020139 Canis familiaris 78.53 0.00e+00 732.00
IUUC-Cpo-021710 Cavia porcellus 94.38 0.00e+00 1148.00
IUUC-Cre-022746 Chlamydomonas reinhardtii 41.55 1.00e-68 254.00
IUUC-Csa-023546 Chlorocebus sabaeus 95.14 0.00e+00 1053.00
IUUC-Cin-025156 Ciona intestinalis 42.02 5.00e-157 548.00
IUUC-Csv-025962 Ciona savignyi 49.66 9.00e-90 323.00
IUUC-Dre-028215 Danio rerio 61.64 0.00e+00 833.00
IUUC-Dno-029314 Dasypus novemcinctus 93.16 0.00e+00 1090.00
IUUC-Dor-030482 Dipodomys ordii 95.14 0.00e+00 1194.00
IUUC-Dme-032188 Drosophila melanogaster 40.69 6.00e-59 222.00
IUUC-Eca-034143 Equus caballus 93.31 0.00e+00 1150.00
IUUC-Fca-035924 Felis catus 94.22 0.00e+00 1129.00
IUUC-Fal-037387 Ficedula albicollis 79.00 0.00e+00 987.00
IUUC-Gmo-038692 Gadus morhua 64.82 5.00e-152 531.00
IUUC-Gga-040597 Gallus gallus 78.82 0.00e+00 1031.00
IUUC-Gac-042004 Gasterosteus aculeatus 61.84 0.00e+00 817.00
IUUC-Gma-044134 Glycine max 32.11 1.00e-103 370.00
IUUC-Ggo-044761 Gorilla gorilla 95.29 0.00e+00 1073.00
IUUC-Hsa-045698 Homo sapiens 95.14 0.00e+00 1093.00
IUUC-Hvu-047649 Hordeum vulgare 53.38 1.00e-102 367.00
IUUC-Itr-048697 Ictidomys tridecemlineatus 94.38 0.00e+00 1124.00
IUUC-Lch-049674 Latimeria chalumnae 67.74 0.00e+00 914.00
IUUC-Lpe-051554 Leersia perrieri 54.39 7.00e-105 375.00
IUUC-Loc-052623 Lepisosteus oculatus 66.09 0.00e+00 888.00
IUUC-Laf-054587 Loxodonta africana 94.38 0.00e+00 1148.00
IUUC-Mcc-055851 Macaca mulatta 95.14 0.00e+00 1073.00
IUUC-Meu-056704 Macropus eugenii 88.91 0.00e+00 1148.00
IUUC-Mtr-058053 Medicago truncatula 52.68 2.00e-103 370.00
IUUC-Mga-059608 Meleagris gallopavo 78.42 0.00e+00 1016.00
IUUC-Mmr-061154 Microcebus murinus 92.87 0.00e+00 1092.00
IUUC-Mdo-062365 Monodelphis domestica 85.37 0.00e+00 1082.00
IUUC-Mac-064667 Musa acuminata 52.76 2.00e-99 356.00
IUUC-Mpu-066245 Mustela putorius furo 94.07 0.00e+00 1085.00
IUUC-Mlu-067692 Myotis lucifugus 94.47 0.00e+00 1120.00
IUUC-Nle-070051 Nomascus leucogenys 92.55 0.00e+00 1056.00
IUUC-Opr-070855 Ochotona princeps 94.22 0.00e+00 1139.00
IUUC-Ont-071883 Oreochromis niloticus 59.21 0.00e+00 811.00
IUUC-Oan-073293 Ornithorhynchus anatinus 89.11 0.00e+00 1006.00
IUUC-Ocu-074644 Oryctolagus cuniculus 94.98 0.00e+00 1153.00
IUUC-Oba-075448 Oryza barthii 54.73 3.00e-105 376.00
IUUC-Obr-076385 Oryza brachyantha 53.72 3.00e-104 373.00
IUUC-Ogl-077427 Oryza glaberrima 54.73 1.00e-105 378.00
IUUC-Ogu-079022 Oryza glumaepatula 49.35 2.00e-97 350.00
IUUC-Oin-079811 Oryza indica 52.27 2.00e-102 367.00
IUUC-Olo-080245 Oryza longistaminata 52.27 2.00e-102 367.00
IUUC-Ome-081239 Oryza meridionalis 54.14 6.00e-102 365.00
IUUC-Oni-082640 Oryza nivara 54.73 3.00e-105 376.00
IUUC-Opu-083748 Oryza punctata 54.39 8.00e-105 375.00
IUUC-Oru-084609 Oryza rufipogon 54.73 3.00e-105 376.00
IUUC-Osa-086267 Oryza sativa 49.35 1.00e-97 350.00
IUUC-Ola-087483 Oryzias latipes 56.28 0.00e+00 630.00
IUUC-Oga-087964 Otolemur garnettii 94.53 0.00e+00 1160.00
IUUC-Oar-089483 Ovis aries 91.59 0.00e+00 1103.00
IUUC-Ptr-091387 Pan troglodytes 95.29 0.00e+00 1095.00
IUUC-Pan-092623 Papio anubis 95.14 0.00e+00 1073.00
IUUC-Psi-093830 Pelodiscus sinensis 80.87 0.00e+00 1039.00
IUUC-Pma-094135 Petromyzon marinus 44.06 4.00e-37 147.00
IUUC-Ppa-095379 Physcomitrella patens 54.67 1.00e-96 347.00
IUUC-Pfo-096755 Poecilia formosa 57.45 0.00e+00 785.00
IUUC-Pab-097564 Pongo abelii 93.86 0.00e+00 944.00
IUUC-Pop-099149 Populus trichocarpa 52.68 5.00e-103 369.00
IUUC-Pca-100357 Procavia capensis 99.52 4.00e-126 445.00
IUUC-Ppe-101237 Prunus persica 52.68 8.00e-103 368.00
IUUC-Pva-102397 Pteropus vampyrus 89.97 0.00e+00 1052.00
IUUC-Rno-105349 Rattus norvegicus 97.87 0.00e+00 1214.00
IUUC-Smo-109409 Selaginella moellendorffii 53.98 7.00e-100 358.00
IUUC-Sit-110360 Setaria italica 54.73 4.00e-105 376.00
IUUC-Sly-111307 Solanum lycopersicum 53.02 1.00e-98 354.00
IUUC-Stu-112462 Solanum tuberosum 52.60 5.00e-95 342.00
IUUC-Sar-112953 Sorex araneus 82.02 5.00e-109 388.00
IUUC-Sbi-114389 Sorghum bicolor 47.46 4.00e-94 339.00
IUUC-Ssc-115949 Sus scrofa 90.27 0.00e+00 834.00
IUUC-Tgu-117461 Taeniopygia guttata 78.23 0.00e+00 1012.00
IUUC-Tru-117865 Takifugu rubripes 59.12 0.00e+00 778.00
IUUC-Tsy-119036 Tarsius syrichta 78.23 4.00e-75 275.00
IUUC-Tni-120903 Tetraodon nigroviridis 60.30 0.00e+00 767.00
IUUC-Tca-121185 Theobroma cacao 51.68 4.00e-100 359.00
IUUC-Tae-125263 Triticum aestivum 53.72 9.00e-103 368.00
IUUC-Tur-126181 Triticum urartu 48.45 4.00e-94 339.00
IUUC-Tbe-127518 Tupaia belangeri 79.56 2.00e-176 612.00
IUUC-Ttr-128172 Tursiops truncatus 93.62 0.00e+00 1111.00
IUUC-Vvi-131489 Vitis vinifera 53.36 2.00e-103 370.00
IUUC-Xtr-132915 Xenopus tropicalis 73.17 0.00e+00 954.00
IUUC-Xma-134133 Xiphophorus maculatus 57.31 0.00e+00 776.00
Created Date 25-Jun-2017

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