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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046853
Ensembl Protein ID ENSP00000382507.2
UniProt Accession Q14CS0; B3KWZ3; UBX2B_HUMAN
Genbank Protein ID BAG54305.1; AAI13646.1
Protein Name UBX domain-containing protein 2B; NSFL1 cofactor p37; p97 cofactor p37
Genbank Nucleotide ID AK126300; BC113645
Gene Name UBXN2B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000215114.7 ENST00000399598.6 ENSP00000382507.2
ENSG00000215114.7 ENST00000520732.5 ENSP00000427759.1
ENSG00000215114.7 ENST00000523409.5 ENSP00000428314.1
ENSG00000215114.7 ENST00000521796.1 ENSP00000428241.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UFD/UBX 4.30e-14 54.5 255 327
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/UBX
   S: 4    eqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsl 77
           +++++qiRl+dG+rl ++F+s++++ ++++f+   +  +    F Lv++fP+++l++e+   tl ea+++++  l
   Q: 255  PTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVqSRPEFAALDFILVTSFPNKELTDESL--TLLEADILNTVLL 327
           589******************************7788889999*****************..********99877 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
 Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
Protein Sequence
(Fasta)
MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK ATVFKSPRTP 60
PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL NEATRASGDD KSKSFTGGGY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046853|ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTTCGGGTA GCGGGGACGC GCACGCACCT TGCGCGTCTT CGCCCCTCCT GCGGTTGCCA 60
GGCAACCGGC CCCGGAAGTT GCGGCAGGTG CGTCCGCAGC GGGCGCCGCT AGCCAGCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046853|ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR012989--SEP_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS51399--SEP
PS50033--UBX
Pfam

PF08059--SEP
PF00789--UBX
SMART

SM00553--SEP
SM00166--UBX
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0043130--F:ubiquitin binding
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG hsa:137886
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001637 Ailuropoda melanoleuca 95.47 0.00e+00 640.00
IUUC-Apl-003738 Anas platyrhynchos 71.56 1.00e-121 429.00
IUUC-Aca-005097 Anolis carolinensis 72.67 5.00e-124 437.00
IUUC-Acl-008176 Aspergillus clavatus 39.66 3.00e-30 125.00
IUUC-Afl-008553 Aspergillus flavus 34.03 6.00e-25 108.00
IUUC-Aor-010016 Aspergillus oryzae 34.03 6.00e-25 108.00
IUUC-Bta-012629 Bos taurus 91.59 6.00e-160 556.00
IUUC-Cja-019732 Callithrix jacchus 85.50 9.00e-148 516.00
IUUC-Cfa-021132 Canis familiaris 95.47 0.00e+00 643.00
IUUC-Cpo-021389 Cavia porcellus 89.94 4.00e-168 583.00
IUUC-Csa-023362 Chlorocebus sabaeus 98.19 0.00e+00 640.00
IUUC-Cgl-026628 Colletotrichum gloeosporioides 32.78 8.00e-23 101.00
IUUC-Dno-029956 Dasypus novemcinctus 92.62 5.00e-169 587.00
IUUC-Dor-031124 Dipodomys ordii 83.12 1.00e-139 489.00
IUUC-Eca-034063 Equus caballus 92.45 0.00e+00 626.00
IUUC-Fca-035606 Felis catus 92.75 4.00e-180 623.00
IUUC-Fal-036923 Ficedula albicollis 72.89 9.00e-123 433.00
IUUC-Ggr-039971 Gaeumannomyces graminis 26.57 1.00e-14 74.30
IUUC-Gga-040906 Gallus gallus 71.12 4.00e-140 490.00
IUUC-Ggo-044801 Gorilla gorilla 100.00 0.00e+00 629.00
IUUC-Hvu-047203 Hordeum vulgare 31.89 2.00e-29 122.00
IUUC-Itr-047910 Ictidomys tridecemlineatus 94.27 6.00e-146 509.00
IUUC-Lpe-051122 Leersia perrieri 35.00 1.00e-32 134.00
IUUC-Lma-053319 Leptosphaeria maculans 33.83 1.00e-33 137.00
IUUC-Laf-053854 Loxodonta africana 89.56 8.00e-157 546.00
IUUC-Mcc-055607 Macaca mulatta 98.19 0.00e+00 627.00
IUUC-Mpo-057595 Magnaporthe poae 29.78 2.00e-19 90.10
IUUC-Mga-059714 Meleagris gallopavo 74.62 2.00e-132 465.00
IUUC-Mmr-061091 Microcebus murinus 96.10 6.00e-175 606.00
IUUC-Mdo-062985 Monodelphis domestica 79.45 1.00e-150 526.00
IUUC-Mmu-064382 Mus musculus 85.50 4.00e-157 547.00
IUUC-Mpu-066168 Mustela putorius furo 96.21 1.00e-180 625.00
IUUC-Mlu-067562 Myotis lucifugus 89.73 2.00e-166 578.00
IUUC-Nfi-068609 Neosartorya fischeri 37.99 2.00e-29 123.00
IUUC-Ncr-068786 Neurospora crassa 34.78 1.00e-24 107.00
IUUC-Nle-069639 Nomascus leucogenys 99.68 0.00e+00 626.00
IUUC-Oan-073007 Ornithorhynchus anatinus 84.87 6.00e-151 526.00
IUUC-Ocu-074507 Oryctolagus cuniculus 93.05 5.00e-176 610.00
IUUC-Oin-079640 Oryza indica 35.25 7.00e-34 138.00
IUUC-Olo-080962 Oryza longistaminata 34.80 2.00e-31 129.00
IUUC-Ome-081766 Oryza meridionalis 35.40 2.00e-31 131.00
IUUC-Opu-083365 Oryza punctata 34.53 4.00e-34 139.00
IUUC-Oga-088292 Otolemur garnettii 83.71 1.00e-147 516.00
IUUC-Oar-090236 Ovis aries 89.97 3.00e-155 540.00
IUUC-Ptr-090664 Pan troglodytes 100.00 0.00e+00 629.00
IUUC-Pan-092072 Papio anubis 98.36 5.00e-177 613.00
IUUC-Psi-093486 Pelodiscus sinensis 80.26 4.00e-133 467.00
IUUC-Pab-097813 Pongo abelii 100.00 0.00e+00 629.00
IUUC-Pca-100985 Procavia capensis 77.61 7.00e-108 383.00
IUUC-Ppe-101417 Prunus persica 34.30 1.00e-33 137.00
IUUC-Pva-102600 Pteropus vampyrus 93.83 1.00e-176 612.00
IUUC-Rno-105047 Rattus norvegicus 88.96 8.00e-162 562.00
IUUC-Sha-106777 Sarcophilus harrisii 83.13 6.00e-75 273.00
IUUC-Sbi-114513 Sorghum bicolor 33.82 2.00e-33 137.00
IUUC-Ssc-115936 Sus scrofa 93.53 8.00e-159 552.00
IUUC-Tgu-116752 Taeniopygia guttata 73.98 6.00e-129 453.00
IUUC-Tsy-119015 Tarsius syrichta 79.87 5.00e-140 490.00
IUUC-Ttr-128760 Tursiops truncatus 93.06 3.00e-165 574.00
IUUC-Vpa-130155 Vicugna pacos 92.41 1.00e-158 552.00
Created Date 25-Jun-2017

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