iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132237

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

SMAD-specific E3 ubiquitin protein ligase 1

Genbank Nucleotide ID

AAMC01000731

Gene Name

smurf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007498.3	ENSXETT00000016335.3	ENSXETP00000016335.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-127	425.6	419	754

Active Site

Position(s)	Description	Evidence
723	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 419  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 506
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g   ++eLkp+G+n +Vt+eNk+eYv+l+v+
   Q: 507  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVN 591
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + ++s+ +qwFw+++e+f++e r+++LqFv
   Q: 592  WRFMRGIEAQFLALQKGFNELIPQHLLKPFEQKELELIIGGLDKIDISDWKANTRLKH-CLANSNIVQWFWQAVESFDEERRARLLQFV 679
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet+gF +
   Q: 680  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETSGFAV 754
           ******************************99999**************************************76 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSNAVTRRGG SSIRVRLTVL CAKNLAKRDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKMDSITISI WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAACG CTGTGACTCG GAGAGGTGGA TCGAGTATCA GAGTTCGTCT GACAGGTAAA 60
GACGAGTCGT ACTCAAGGGT AGTACGGAAT TACTGTATTG AAGCTCTGGA ACGGTAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	82.86	0.00e+00	1308.00
IUUC-Apl-004155	Anas platyrhynchos	88.74	0.00e+00	1367.00
IUUC-Aca-005238	Anolis carolinensis	86.92	0.00e+00	1351.00
IUUC-Ame-010901	Astyanax mexicanus	85.17	0.00e+00	1328.00
IUUC-Bta-013221	Bos taurus	81.76	0.00e+00	1240.00
IUUC-Cja-018985	Callithrix jacchus	87.76	0.00e+00	1376.00
IUUC-Cfa-020568	Canis familiaris	87.14	0.00e+00	1351.00
IUUC-Cpo-022531	Cavia porcellus	87.50	0.00e+00	1371.00
IUUC-Csa-024145	Chlorocebus sabaeus	87.30	0.00e+00	1358.00
IUUC-Cho-024963	Choloepus hoffmanni	76.39	0.00e+00	716.00
IUUC-Dre-028341	Danio rerio	85.45	0.00e+00	1337.00
IUUC-Dno-029705	Dasypus novemcinctus	86.45	0.00e+00	1343.00
IUUC-Dme-031740	Drosophila melanogaster	70.30	4.00e-175	608.00
IUUC-Eca-034125	Equus caballus	87.87	0.00e+00	1347.00
IUUC-Fca-035905	Felis catus	87.57	0.00e+00	1341.00
IUUC-Fal-037336	Ficedula albicollis	87.97	0.00e+00	1345.00
IUUC-Gmo-039486	Gadus morhua	75.54	0.00e+00	847.00
IUUC-Gga-040218	Gallus gallus	89.02	0.00e+00	1389.00
IUUC-Gac-041707	Gasterosteus aculeatus	80.73	0.00e+00	1237.00
IUUC-Ggo-045408	Gorilla gorilla	83.24	0.00e+00	1254.00
IUUC-Hsa-045878	Homo sapiens	87.99	0.00e+00	1380.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	88.23	0.00e+00	1348.00
IUUC-Loc-052628	Lepisosteus oculatus	79.41	0.00e+00	1300.00
IUUC-Laf-053644	Loxodonta africana	82.68	0.00e+00	1285.00
IUUC-Mcc-055479	Macaca mulatta	80.29	0.00e+00	1213.00
IUUC-Meu-056436	Macropus eugenii	55.35	0.00e+00	814.00
IUUC-Mga-059723	Meleagris gallopavo	84.67	0.00e+00	1317.00
IUUC-Mdo-063005	Monodelphis domestica	88.08	0.00e+00	1375.00
IUUC-Mmu-063634	Mus musculus	87.30	0.00e+00	1356.00
IUUC-Mpu-065898	Mustela putorius furo	87.48	0.00e+00	1343.00
IUUC-Mlu-067584	Myotis lucifugus	85.83	0.00e+00	1345.00
IUUC-Nle-069033	Nomascus leucogenys	88.38	0.00e+00	1354.00
IUUC-Ont-072265	Oreochromis niloticus	81.47	0.00e+00	1262.00
IUUC-Oan-073621	Ornithorhynchus anatinus	82.95	0.00e+00	1329.00
IUUC-Ocu-073960	Oryctolagus cuniculus	87.77	0.00e+00	1338.00
IUUC-Ola-086597	Oryzias latipes	72.42	0.00e+00	1113.00
IUUC-Oga-088579	Otolemur garnettii	87.89	0.00e+00	1378.00
IUUC-Oar-090396	Ovis aries	86.16	0.00e+00	1271.00
IUUC-Ptr-091624	Pan troglodytes	87.99	0.00e+00	1380.00
IUUC-Pan-092479	Papio anubis	88.24	0.00e+00	1353.00
IUUC-Pfo-097203	Poecilia formosa	80.47	0.00e+00	1248.00
IUUC-Pab-097540	Pongo abelii	87.45	0.00e+00	1314.00
IUUC-Pca-100379	Procavia capensis	67.60	1.00e-172	600.00
IUUC-Rno-105396	Rattus norvegicus	87.30	0.00e+00	1357.00
IUUC-Sha-107216	Sarcophilus harrisii	87.58	0.00e+00	1362.00
IUUC-Ssc-116413	Sus scrofa	87.06	0.00e+00	1302.00
IUUC-Tgu-116723	Taeniopygia guttata	88.53	0.00e+00	1361.00
IUUC-Tru-117843	Takifugu rubripes	78.39	0.00e+00	1224.00
IUUC-Tsy-119455	Tarsius syrichta	87.45	0.00e+00	1275.00
IUUC-Tni-120037	Tetraodon nigroviridis	79.45	0.00e+00	1185.00
IUUC-Tbe-127879	Tupaia belangeri	74.29	0.00e+00	1082.00
IUUC-Ttr-128423	Tursiops truncatus	87.45	0.00e+00	1296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence