iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090093

Ensembl Protein ID

ENSOARP00000016901.1

UniProt Accession

W5Q2G3; W5Q2G3_SHEEP

Genbank Protein ID

ENSOARP00000016901

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01051687

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015710.1	ENSOART00000017140.1	ENSOARP00000016901.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-86	291.4	4468	4797

Active Site

Position(s)	Description	Evidence
4766	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l +p      h+++F+flG+llg+a+++g +l
   Q: 4468 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLFSPaarapVHTNMFRFLGVLLGIAIRTGSPL 4554
           4566****************************************************99999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4555 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEYVR 4636
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFwev+e+fs++er+
   Q: 4637 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPSAPLIQWFWEVMESFSNTERS 4721
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4722 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4797
           *************.8*************999988888***********************************99875 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MPSDSFCLAA QTRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELSQNGELPP 60
RKDDGVDTQI GTKKEDLNDK EKKEEEETPA PAYRAKSILE SWVWGQQPDV NELKECLSVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTGAATTT TGATTAATTT ATTTCACGCA CCAGTTGGTG CTCTGAGGTA AAGCGGATAA 60
TGCATGCTGG TGTCATTTGT CGTGGAGACG TGGGGTTCCT GCAGTTTGTG TGTTAACCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	97.18	0.00e+00	7217.00
IUUC-Atr-003065	Amborella trichopoda	35.29	5.00e-51	196.00
IUUC-Apl-003983	Anas platyrhynchos	90.78	0.00e+00	8373.00
IUUC-Aca-004300	Anolis carolinensis	89.69	0.00e+00	8235.00
IUUC-Aly-006441	Arabidopsis lyrata	34.15	1.00e-44	175.00
IUUC-Ame-010621	Astyanax mexicanus	84.89	0.00e+00	6930.00
IUUC-Bta-013067	Bos taurus	99.13	0.00e+00	8945.00
IUUC-Bdi-014093	Brachypodium distachyon	33.25	4.00e-49	190.00
IUUC-Bol-015203	Brassica oleracea	34.55	1.00e-52	202.00
IUUC-Bra-016737	Brassica rapa	34.55	7.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	93.86	0.00e+00	8423.00
IUUC-Cfa-020672	Canis familiaris	97.11	0.00e+00	8831.00
IUUC-Cpo-021819	Cavia porcellus	92.75	0.00e+00	8430.00
IUUC-Csa-023817	Chlorocebus sabaeus	95.74	0.00e+00	8669.00
IUUC-Cho-024387	Choloepus hoffmanni	94.19	0.00e+00	1880.00
IUUC-Cin-025709	Ciona intestinalis	54.62	0.00e+00	2234.00
IUUC-Csv-026336	Ciona savignyi	42.02	0.00e+00	3021.00
IUUC-Dre-027717	Danio rerio	82.16	0.00e+00	7274.00
IUUC-Dno-029296	Dasypus novemcinctus	95.04	0.00e+00	8640.00
IUUC-Dor-030979	Dipodomys ordii	89.71	0.00e+00	2883.00
IUUC-Dme-032171	Drosophila melanogaster	60.67	0.00e+00	1553.00
IUUC-Ete-032687	Echinops telfairi	85.29	0.00e+00	2887.00
IUUC-Eca-034046	Equus caballus	96.43	0.00e+00	8762.00
IUUC-Eeu-034859	Erinaceus europaeus	84.34	0.00e+00	1952.00
IUUC-Fca-036262	Felis catus	97.00	0.00e+00	8825.00
IUUC-Fal-037562	Ficedula albicollis	90.46	0.00e+00	8294.00
IUUC-Gmo-039054	Gadus morhua	86.48	0.00e+00	1088.00
IUUC-Gga-040359	Gallus gallus	90.67	0.00e+00	8328.00
IUUC-Gac-041879	Gasterosteus aculeatus	90.57	0.00e+00	1040.00
IUUC-Ggo-044692	Gorilla gorilla	96.74	0.00e+00	4306.00
IUUC-Hsa-045995	Homo sapiens	95.89	0.00e+00	8721.00
IUUC-Hvu-047529	Hordeum vulgare	35.65	4.00e-49	190.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	93.73	0.00e+00	2407.00
IUUC-Lch-049808	Latimeria chalumnae	86.91	0.00e+00	3361.00
IUUC-Loc-052685	Lepisosteus oculatus	84.51	0.00e+00	7579.00
IUUC-Laf-053372	Loxodonta africana	94.63	0.00e+00	8586.00
IUUC-Mcc-054693	Macaca mulatta	95.78	0.00e+00	8706.00
IUUC-Meu-056660	Macropus eugenii	95.82	0.00e+00	1924.00
IUUC-Mga-059371	Meleagris gallopavo	90.82	0.00e+00	7179.00
IUUC-Mmr-060787	Microcebus murinus	96.20	0.00e+00	8817.00
IUUC-Mdo-062518	Monodelphis domestica	88.99	0.00e+00	8045.00
IUUC-Mmu-063690	Mus musculus	94.40	0.00e+00	8564.00
IUUC-Mpu-066478	Mustela putorius furo	96.80	0.00e+00	8763.00
IUUC-Mlu-067596	Myotis lucifugus	91.05	0.00e+00	4408.00
IUUC-Nle-069445	Nomascus leucogenys	95.95	0.00e+00	2192.00
IUUC-Opr-070990	Ochotona princeps	87.70	0.00e+00	2987.00
IUUC-Ont-072285	Oreochromis niloticus	83.05	0.00e+00	7373.00
IUUC-Oan-072721	Ornithorhynchus anatinus	86.09	0.00e+00	3450.00
IUUC-Ocu-074273	Oryctolagus cuniculus	95.55	0.00e+00	8711.00
IUUC-Oba-075573	Oryza barthii	33.42	3.00e-45	177.00
IUUC-Obr-076107	Oryza brachyantha	33.77	6.00e-50	192.00
IUUC-Ogl-077193	Oryza glaberrima	33.42	2.00e-45	177.00
IUUC-Ogu-078817	Oryza glumaepatula	33.42	2.00e-45	177.00
IUUC-Oin-079609	Oryza indica	32.49	7.00e-49	189.00
IUUC-Olo-080629	Oryza longistaminata	33.42	3.00e-45	177.00
IUUC-Opu-084137	Oryza punctata	33.68	7.00e-46	179.00
IUUC-Oru-085013	Oryza rufipogon	33.42	2.00e-45	177.00
IUUC-Osa-085597	Oryza sativa	33.42	3.00e-45	177.00
IUUC-Ola-087346	Oryzias latipes	92.45	0.00e+00	1206.00
IUUC-Oga-088742	Otolemur garnettii	95.29	0.00e+00	8600.00
IUUC-Ptr-091034	Pan troglodytes	90.15	0.00e+00	5670.00
IUUC-Pan-092783	Papio anubis	93.41	0.00e+00	8462.00
IUUC-Psi-094027	Pelodiscus sinensis	90.56	0.00e+00	7974.00
IUUC-Pfo-096208	Poecilia formosa	80.60	0.00e+00	6029.00
IUUC-Pab-097681	Pongo abelii	92.23	0.00e+00	2560.00
IUUC-Pca-100705	Procavia capensis	94.74	0.00e+00	1171.00
IUUC-Pva-103147	Pteropus vampyrus	87.70	0.00e+00	2531.00
IUUC-Rno-105458	Rattus norvegicus	94.46	0.00e+00	8557.00
IUUC-Sha-106959	Sarcophilus harrisii	81.10	0.00e+00	6979.00
IUUC-Sit-109917	Setaria italica	36.47	3.00e-48	186.00
IUUC-Sly-110961	Solanum lycopersicum	35.33	7.00e-53	202.00
IUUC-Sar-113532	Sorex araneus	84.46	0.00e+00	1810.00
IUUC-Sbi-114352	Sorghum bicolor	32.13	3.00e-49	190.00
IUUC-Ssc-115337	Sus scrofa	95.21	0.00e+00	3118.00
IUUC-Tgu-116789	Taeniopygia guttata	90.55	0.00e+00	8318.00
IUUC-Tru-118129	Takifugu rubripes	82.14	0.00e+00	7382.00
IUUC-Tsy-119302	Tarsius syrichta	83.99	0.00e+00	1258.00
IUUC-Tni-120374	Tetraodon nigroviridis	80.70	0.00e+00	7225.00
IUUC-Tca-121094	Theobroma cacao	35.31	1.00e-53	205.00
IUUC-Tae-124157	Triticum aestivum	33.51	2.00e-49	191.00
IUUC-Tbe-128137	Tupaia belangeri	87.67	0.00e+00	2328.00
IUUC-Ttr-128273	Tursiops truncatus	92.86	0.00e+00	6509.00
IUUC-Vpa-130471	Vicugna pacos	83.85	0.00e+00	1488.00
IUUC-Xtr-132185	Xenopus tropicalis	85.39	0.00e+00	7753.00
IUUC-Xma-133233	Xiphophorus maculatus	82.76	0.00e+00	7368.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence