iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062035

Ensembl Protein ID

ENSMODP00000024291.3

UniProt Accession

F6RBD8; F6RBD8_MONDO

Protein Name

Tyrosine-protein kinase

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019471.3	ENSMODT00000024721.3	ENSMODP00000024291.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.90e-16	58.6	93	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v +lydyea ++++L+++kGd++ ++   e++++W+++ + ++ k+G +P+n+v++++
   Q: 93   TVVALYDYEAIHNEDLSFRKGDQMAIL---EKSGEWWRARSLATRKEGYIPSNYVAQVN 148
           799************************...**************************997 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MPQKRRGPQK TEVGAPGAGL KPQKLGHFGR LKARMGCVKS RFNQDGRKIF KKDSPTNNQG 60
PVYVPDPTSP GKRVVNGANQ SISSDASENV DITVVALYDY EAIHNEDLSF RKGDQMAILE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAAGAGAA ATGAGCTATC AATGGAGAGA GTTGAAAAAC CTGAAGGATA ACAGCTTGAT 60
CTCCGCGTCT CCCAGAGCCT CTGCGGCCCT TTCTGTGCTA CAGACTTTGC ATAATGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mdo:100010539

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	85.01	0.00e+00	894.00
IUUC-Apl-003285	Anas platyrhynchos	76.18	0.00e+00	796.00
IUUC-Aca-004724	Anolis carolinensis	75.79	0.00e+00	777.00
IUUC-Ame-011954	Astyanax mexicanus	74.41	0.00e+00	760.00
IUUC-Bta-013060	Bos taurus	84.95	0.00e+00	900.00
IUUC-Cja-019817	Callithrix jacchus	83.43	0.00e+00	875.00
IUUC-Cfa-020511	Canis familiaris	83.96	0.00e+00	894.00
IUUC-Cpo-022538	Cavia porcellus	83.04	0.00e+00	867.00
IUUC-Csa-024143	Chlorocebus sabaeus	82.68	0.00e+00	881.00
IUUC-Dre-028157	Danio rerio	74.75	0.00e+00	782.00
IUUC-Dno-029761	Dasypus novemcinctus	82.54	0.00e+00	874.00
IUUC-Eca-034090	Equus caballus	82.18	0.00e+00	860.00
IUUC-Fca-035937	Felis catus	83.60	0.00e+00	857.00
IUUC-Fal-036624	Ficedula albicollis	77.21	0.00e+00	808.00
IUUC-Gmo-039009	Gadus morhua	71.43	0.00e+00	739.00
IUUC-Gga-040296	Gallus gallus	73.57	0.00e+00	780.00
IUUC-Gac-042362	Gasterosteus aculeatus	72.78	0.00e+00	770.00
IUUC-Ggo-044570	Gorilla gorilla	83.30	0.00e+00	874.00
IUUC-Hsa-046378	Homo sapiens	83.50	0.00e+00	877.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	83.60	0.00e+00	885.00
IUUC-Loc-052904	Lepisosteus oculatus	77.84	0.00e+00	819.00
IUUC-Laf-053654	Loxodonta africana	84.55	0.00e+00	893.00
IUUC-Mcc-055317	Macaca mulatta	84.16	0.00e+00	884.00
IUUC-Mga-060194	Meleagris gallopavo	79.19	0.00e+00	754.00
IUUC-Mmr-061510	Microcebus murinus	84.42	0.00e+00	880.00
IUUC-Mmu-064037	Mus musculus	82.97	0.00e+00	889.00
IUUC-Mpu-066874	Mustela putorius furo	84.58	0.00e+00	894.00
IUUC-Mlu-068202	Myotis lucifugus	79.73	0.00e+00	861.00
IUUC-Nle-069222	Nomascus leucogenys	83.66	0.00e+00	873.00
IUUC-Opr-070705	Ochotona princeps	82.41	0.00e+00	868.00
IUUC-Ont-072347	Oreochromis niloticus	81.35	0.00e+00	753.00
IUUC-Ocu-074490	Oryctolagus cuniculus	81.35	0.00e+00	863.00
IUUC-Ola-086521	Oryzias latipes	79.82	0.00e+00	761.00
IUUC-Oga-088153	Otolemur garnettii	83.60	0.00e+00	875.00
IUUC-Oar-090184	Ovis aries	84.31	0.00e+00	895.00
IUUC-Ptr-090505	Pan troglodytes	79.57	0.00e+00	822.00
IUUC-Pan-092260	Papio anubis	83.96	0.00e+00	882.00
IUUC-Pma-094311	Petromyzon marinus	73.99	0.00e+00	707.00
IUUC-Pfo-096566	Poecilia formosa	75.54	0.00e+00	793.00
IUUC-Pva-103021	Pteropus vampyrus	84.36	0.00e+00	890.00
IUUC-Rno-105309	Rattus norvegicus	83.53	0.00e+00	890.00
IUUC-Sha-107099	Sarcophilus harrisii	91.13	0.00e+00	1030.00
IUUC-Tgu-116912	Taeniopygia guttata	77.17	0.00e+00	798.00
IUUC-Tru-118449	Takifugu rubripes	80.90	0.00e+00	758.00
IUUC-Tbe-128144	Tupaia belangeri	81.92	0.00e+00	757.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence