iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074490

Ensembl Protein ID

ENSOCUP00000008404.3

UniProt Accession

G1SXU8; G1SXU8_RABIT

Genbank Protein ID

ENSOCUP00000008404

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAGW02060497

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000009751.3	ENSOCUT00000009756.3	ENSOCUP00000008404.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.60e-15	56.2	59	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +l+dyea + ++L+++kGd++ v+   e++++W+k+ + +++ +G +P+n+v++++
   Q: 59   IVVALFDYEAIHREDLSFQKGDQLVVL---EESGEWWKARSLATQEEGYIPSNYVARVN 114
           689************************...99*************************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MGCMKSKFLQ GGRKISKTEP STNLHTTVYV PDPTSSIKPG SSSSHDKPPG LAEGSEDIIV 60
VALFDYEAIH REDLSFQKGD QLVVLEESGE WWKARSLATQ EEGYIPSNYV ARVNSLETEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTTAGCC TCTCCCGAGC GCGGCCGGGG CGTCACTGCG CCCCCGGTGC CAGCAGGGGA 60
GCTTGGCAGT GCTTTGCGCG CAGGAGGAGT CCTCGAAGAC CGGCACGCCA CCCAGAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

KEGG

ocu:100343961

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	30.68	1.00e-22	102.00
IUUC-Aml-001284	Ailuropoda melanoleuca	88.51	0.00e+00	925.00
IUUC-Apl-003285	Anas platyrhynchos	77.36	0.00e+00	798.00
IUUC-Aca-004724	Anolis carolinensis	76.73	0.00e+00	784.00
IUUC-Ame-011954	Astyanax mexicanus	74.11	0.00e+00	757.00
IUUC-Bta-013060	Bos taurus	88.27	0.00e+00	932.00
IUUC-Bdi-014122	Brachypodium distachyon	31.78	7.00e-23	102.00
IUUC-Cja-019817	Callithrix jacchus	88.32	0.00e+00	914.00
IUUC-Cfa-020511	Canis familiaris	87.67	0.00e+00	927.00
IUUC-Cpo-022538	Cavia porcellus	88.89	0.00e+00	929.00
IUUC-Csa-024143	Chlorocebus sabaeus	89.29	0.00e+00	929.00
IUUC-Dre-028157	Danio rerio	74.51	0.00e+00	780.00
IUUC-Dno-029761	Dasypus novemcinctus	85.71	0.00e+00	906.00
IUUC-Eca-034090	Equus caballus	85.49	0.00e+00	897.00
IUUC-Fca-035937	Felis catus	85.88	0.00e+00	881.00
IUUC-Fal-036624	Ficedula albicollis	76.82	0.00e+00	796.00
IUUC-Gmo-039009	Gadus morhua	73.16	0.00e+00	759.00
IUUC-Gga-040296	Gallus gallus	74.36	0.00e+00	781.00
IUUC-Gac-042362	Gasterosteus aculeatus	73.96	0.00e+00	774.00
IUUC-Ggo-044570	Gorilla gorilla	89.11	0.00e+00	925.00
IUUC-Hsa-046378	Homo sapiens	89.11	0.00e+00	928.00
IUUC-Hvu-047855	Hordeum vulgare	30.68	8.00e-23	102.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	87.30	0.00e+00	921.00
IUUC-Loc-052904	Lepisosteus oculatus	78.35	0.00e+00	817.00
IUUC-Laf-053654	Loxodonta africana	87.67	0.00e+00	929.00
IUUC-Mcc-055317	Macaca mulatta	89.68	0.00e+00	937.00
IUUC-Mga-060194	Meleagris gallopavo	79.96	0.00e+00	760.00
IUUC-Mmr-061510	Microcebus murinus	86.51	0.00e+00	914.00
IUUC-Mdo-062035	Monodelphis domestica	81.35	0.00e+00	863.00
IUUC-Mmu-064037	Mus musculus	88.07	0.00e+00	937.00
IUUC-Mpu-066874	Mustela putorius furo	88.29	0.00e+00	931.00
IUUC-Mlu-068202	Myotis lucifugus	83.50	0.00e+00	869.00
IUUC-Nle-069222	Nomascus leucogenys	89.68	0.00e+00	932.00
IUUC-Opr-070705	Ochotona princeps	89.29	0.00e+00	928.00
IUUC-Ont-072347	Oreochromis niloticus	81.39	0.00e+00	758.00
IUUC-Ola-086521	Oryzias latipes	80.49	0.00e+00	772.00
IUUC-Oga-088153	Otolemur garnettii	86.51	0.00e+00	909.00
IUUC-Oar-090184	Ovis aries	87.75	0.00e+00	925.00
IUUC-Ptr-090505	Pan troglodytes	85.15	0.00e+00	872.00
IUUC-Pan-092260	Papio anubis	89.48	0.00e+00	937.00
IUUC-Pma-094311	Petromyzon marinus	74.05	0.00e+00	731.00
IUUC-Pfo-096566	Poecilia formosa	75.15	0.00e+00	783.00
IUUC-Pva-103021	Pteropus vampyrus	87.90	0.00e+00	929.00
IUUC-Rno-105309	Rattus norvegicus	88.07	0.00e+00	937.00
IUUC-Sha-107099	Sarcophilus harrisii	79.88	0.00e+00	851.00
IUUC-Tgu-116912	Taeniopygia guttata	76.13	0.00e+00	787.00
IUUC-Tru-118449	Takifugu rubripes	80.00	0.00e+00	753.00
IUUC-Tae-123706	Triticum aestivum	31.95	1.00e-23	105.00
IUUC-Tur-126022	Triticum urartu	31.95	2.00e-23	105.00
IUUC-Tbe-128144	Tupaia belangeri	83.56	0.00e+00	786.00
IUUC-Xma-133902	Xiphophorus maculatus	74.85	0.00e+00	783.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence