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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063538
UUCD1 version UUC-MuM-00845
Ensembl Protein ID ENSMUSP00000043462.3
UniProt Accession Q91ZU1; Q8VEC6; ASB6_MOUSE
Genbank Protein ID AAK97489.1; AAH19192.1
Protein Name Ankyrin repeat and SOCS box protein 6
Genbank Nucleotide ID AF398967; BC019192
Gene Name Asb6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039483.10 ENSMUST00000041726.3 ENSMUSP00000043462.3
ENSMUSG00000039483.10 ENSMUST00000129628.7 ENSMUSP00000142231.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.10e-15 58.3 361 411
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLlyed 51
           ++l++l+s p++L+hLCR++Ir cl+ + +  ++++LPLP++Lk+YLl+ +
   Q: 361  ASLRQLESYPPPLKHLCRVSIRLCLRPWPVdTKVKALPLPDRLKWYLLSAH 411
           6799********************************************987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MPFLHGFRRI IFEYQPLVDA ILGALGIQDL ERQEPLDDSA SSEESRILVL TELLEQKAHS 60
PFYQEGVSNA LLKMAELGLT RAAAVLLQSG ANLNFEDPVT YYTALHIAVL RNQPDMVELL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063538|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCCCAGTGC TAGGACCCGA GGAGGGCTCC AATAAATGCA AGTTAATTCT CATGTGTTCT 60
ATGTGTATTT ACACTAAGTA TGCATGTATC CACACGTGCT GTATGTGTGT AGAGGTCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063538|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF07525--SOCS_box
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG mmu:72323
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002347 Ailuropoda melanoleuca 90.62 0.00e+00 762.00
IUUC-Apl-004040 Anas platyrhynchos 70.50 1.00e-167 582.00
IUUC-Aca-005115 Anolis carolinensis 63.69 3.00e-109 387.00
IUUC-Bta-013038 Bos taurus 92.03 0.00e+00 773.00
IUUC-Cja-019234 Callithrix jacchus 90.45 0.00e+00 696.00
IUUC-Cfa-021244 Canis familiaris 90.38 0.00e+00 760.00
IUUC-Cpo-021929 Cavia porcellus 88.89 0.00e+00 743.00
IUUC-Csa-023836 Chlorocebus sabaeus 89.95 0.00e+00 760.00
IUUC-Cho-024476 Choloepus hoffmanni 95.24 2.00e-75 275.00
IUUC-Dre-028690 Danio rerio 50.61 4.00e-92 331.00
IUUC-Dno-029283 Dasypus novemcinctus 81.24 0.00e+00 667.00
IUUC-Dor-030485 Dipodomys ordii 87.94 1.00e-175 608.00
IUUC-Ete-032418 Echinops telfairi 83.17 1.00e-154 538.00
IUUC-Eca-033988 Equus caballus 91.18 0.00e+00 689.00
IUUC-Eeu-034941 Erinaceus europaeus 89.37 0.00e+00 749.00
IUUC-Fca-036496 Felis catus 89.71 0.00e+00 763.00
IUUC-Fal-036984 Ficedula albicollis 67.94 3.00e-151 528.00
IUUC-Gmo-039150 Gadus morhua 62.24 2.00e-64 239.00
IUUC-Gga-041266 Gallus gallus 67.46 2.00e-153 535.00
IUUC-Gac-042080 Gasterosteus aculeatus 51.29 2.00e-106 379.00
IUUC-Ggo-044937 Gorilla gorilla 89.90 0.00e+00 757.00
IUUC-Hsa-046356 Homo sapiens 90.14 0.00e+00 761.00
IUUC-Itr-048455 Ictidomys tridecemlineatus 89.53 0.00e+00 697.00
IUUC-Lch-050601 Latimeria chalumnae 66.59 9.00e-152 529.00
IUUC-Loc-052854 Lepisosteus oculatus 53.74 4.00e-107 381.00
IUUC-Laf-054179 Loxodonta africana 90.87 0.00e+00 767.00
IUUC-Mcc-054853 Macaca mulatta 89.71 0.00e+00 760.00
IUUC-Meu-056311 Macropus eugenii 86.16 5.00e-157 546.00
IUUC-Mga-059491 Meleagris gallopavo 64.13 3.00e-140 491.00
IUUC-Mmr-060741 Microcebus murinus 90.62 0.00e+00 767.00
IUUC-Mdo-061962 Monodelphis domestica 82.54 0.00e+00 659.00
IUUC-Mpu-066576 Mustela putorius furo 89.71 0.00e+00 763.00
IUUC-Mlu-067582 Myotis lucifugus 90.03 0.00e+00 680.00
IUUC-Nle-069380 Nomascus leucogenys 89.01 0.00e+00 686.00
IUUC-Opr-070468 Ochotona princeps 83.13 0.00e+00 699.00
IUUC-Ont-071911 Oreochromis niloticus 52.24 3.00e-104 372.00
IUUC-Ola-087028 Oryzias latipes 54.12 3.00e-110 391.00
IUUC-Oga-088844 Otolemur garnettii 90.62 0.00e+00 767.00
IUUC-Oar-089960 Ovis aries 82.34 0.00e+00 676.00
IUUC-Ptr-091084 Pan troglodytes 90.14 0.00e+00 761.00
IUUC-Pan-092635 Papio anubis 90.69 0.00e+00 695.00
IUUC-Psi-093269 Pelodiscus sinensis 75.77 5.00e-180 623.00
IUUC-Pfo-096198 Poecilia formosa 53.81 3.00e-98 352.00
IUUC-Pab-098489 Pongo abelii 91.92 9.00e-179 619.00
IUUC-Pca-100298 Procavia capensis 86.10 0.00e+00 642.00
IUUC-Pva-102166 Pteropus vampyrus 91.95 0.00e+00 647.00
IUUC-Rno-105914 Rattus norvegicus 97.39 0.00e+00 691.00
IUUC-Sha-106776 Sarcophilus harrisii 82.78 0.00e+00 680.00
IUUC-Ssc-116376 Sus scrofa 91.55 0.00e+00 769.00
IUUC-Tgu-116627 Taeniopygia guttata 68.11 1.00e-149 523.00
IUUC-Tru-118229 Takifugu rubripes 51.43 5.00e-103 368.00
IUUC-Tni-120261 Tetraodon nigroviridis 52.54 3.00e-106 378.00
IUUC-Tbe-127507 Tupaia belangeri 90.00 1.00e-83 303.00
IUUC-Ttr-128163 Tursiops truncatus 91.11 0.00e+00 768.00
IUUC-Xtr-132889 Xenopus tropicalis 73.14 1.00e-174 605.00
Created Date 25-Jun-2017

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