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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106237
Ensembl Protein ID YDL015C
UniProt Accession Q99190; D6VRX4; TECR_YEAST
Genbank Protein ID CAA88344.1; CAA98573.1; DAA11834.1
Protein Name Very-long-chain enoyl-CoA reductase; Enoyl reductase TSC13; Temperature-sensitive CSG2 suppressor protein 13; Trans-2-enoyl-CoA reductase
Genbank Nucleotide ID Z48432; Z74063; BK006938
Gene Name TSC13; YDL015C; D2865
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL015C YDL015C YDL015C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 33.75 1.00e-35 144.00 IUUC-Spo-108110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. VLCFAs serve for instance as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress.
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. VLCFAs serve for instance as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress.
Protein Sequence
(Fasta)
MPITIKSRSK GLRDTEIDLS KKPTLDDVLK KISANNHNIS KYRIRLTYKK ESKQVPVISE 60
SFFQEEADDS MEFFIKDLGP QISWRLVFFC EYLGPVLVHS LFYYLSTIPT VVDRWHSASS 120
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Protein Fasta Sequence



>IUUC-Sce-106237|ULD,UBQ_Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGCCTATCA CCATAAAAAG CCGCTCTAAA GGGTTAAGGG ACACTGAAAT TGACTTATCC 60
AAAAAGCCTA CTTTAGATGA TGTTTTGAAA AAAATCTCTG CTAATAACCA CAATATCAGC 120
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Nucleotide Fasta Sequence



>IUUC-Sce-106237|ULD,UBQ_Other|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001104--3-oxo-5_a-steroid_4-DH_C

PROSITE

PS50244--S5A_REDUCTASE

Pfam

PF02544--Steroid_dh

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0009922--F:fatty acid elongase activity
GO:0016491--F:oxidoreductase activity
GO:0016627--F:oxidoreductase activity, acting on the CH-CH group of donors
GO:0006665--P:sphingolipid metabolic process
GO:0042761--P:very long-chain fatty acid biosynthetic process
GO:0000038--P:very long-chain fatty acid metabolic process
GO:0010025--P:wax biosynthetic process

KEGG sce:YDL015C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000125 Aegilops tauschii 31.15 1.00e-32 131.00
IUUC-Aml-001579 Ailuropoda melanoleuca 31.85 3.00e-28 117.00
IUUC-Atr-002693 Amborella trichopoda 27.10 4.00e-23 99.80
IUUC-Apl-004113 Anas platyrhynchos 31.67 3.00e-27 113.00
IUUC-Aca-004681 Anolis carolinensis 32.74 2.00e-27 114.00
IUUC-Aly-005795 Arabidopsis lyrata 30.84 1.00e-28 118.00
IUUC-Ath-007255 Arabidopsis thaliana 30.84 4.00e-28 116.00
IUUC-Ago-007822 Ashbya gossypii 58.84 8.00e-106 374.00
IUUC-Acl-008131 Aspergillus clavatus 32.92 2.00e-31 127.00
IUUC-Afl-008670 Aspergillus flavus 32.32 2.00e-25 107.00
IUUC-Afu-009058 Aspergillus fumigatus 32.61 3.00e-27 113.00
IUUC-Ani-009299 Aspergillus nidulans 32.95 2.00e-26 110.00
IUUC-Ang-009520 Aspergillus niger 32.24 6.00e-29 119.00
IUUC-Aor-010023 Aspergillus oryzae 32.56 5.00e-36 142.00
IUUC-Ate-010593 Aspergillus terreus 31.89 3.00e-32 129.00
IUUC-Ame-011087 Astyanax mexicanus 31.10 1.00e-26 111.00
IUUC-Bgr-012251 Blumeria graminis 34.55 2.00e-26 110.00
IUUC-Bta-013170 Bos taurus 32.57 2.00e-28 117.00
IUUC-Bci-013894 Botrytis cinerea 33.87 2.00e-38 150.00
IUUC-Bdi-015014 Brachypodium distachyon 31.38 1.00e-32 131.00
IUUC-Bol-015761 Brassica oleracea 30.84 1.00e-28 117.00
IUUC-Bra-016894 Brassica rapa 31.17 8.00e-29 118.00
IUUC-Cel-018599 Caenorhabditis elegans 34.88 2.00e-37 147.00
IUUC-Cja-019333 Callithrix jacchus 32.18 1.00e-27 115.00
IUUC-Cfa-020709 Canis familiaris 32.18 1.00e-27 115.00
IUUC-Cpo-022353 Cavia porcellus 32.18 9.00e-28 115.00
IUUC-Cre-023020 Chlamydomonas reinhardtii 31.58 6.00e-28 115.00
IUUC-Csa-023716 Chlorocebus sabaeus 32.18 9.00e-28 115.00
IUUC-Csv-025915 Ciona savignyi 35.08 6.00e-32 129.00
IUUC-Cgl-026580 Colletotrichum gloeosporioides 32.52 2.00e-32 130.00
IUUC-Cne-027086 Cryptococcus neoformans 26.05 6.00e-18 82.40
IUUC-Cme-027185 Cyanidioschyzon merolae 32.99 2.00e-30 123.00
IUUC-Dre-028710 Danio rerio 30.74 5.00e-27 112.00
IUUC-Dno-029631 Dasypus novemcinctus 28.33 2.00e-16 78.20
IUUC-Dor-030220 Dipodomys ordii 32.18 2.00e-27 114.00
IUUC-Dse-031218 Dothistroma septosporum 33.13 1.00e-36 144.00
IUUC-Dme-031792 Drosophila melanogaster 32.78 1.00e-30 124.00
IUUC-Ete-032441 Echinops telfairi 33.33 2.00e-17 80.50
IUUC-Eca-033372 Equus caballus 32.18 7.00e-28 115.00
IUUC-Eeu-035351 Erinaceus europaeus 34.38 9.00e-15 72.00
IUUC-Fca-035630 Felis catus 32.18 1.00e-27 114.00
IUUC-Fal-037646 Ficedula albicollis 33.18 4.00e-23 99.40
IUUC-Fox-037721 Fusarium oxysporum 31.14 9.00e-26 108.00
IUUC-Fso-038379 Fusarium solani 31.62 2.00e-30 124.00
IUUC-Gmo-039616 Gadus morhua 28.52 2.00e-24 104.00
IUUC-Ggr-039727 Gaeumannomyces graminis 28.27 4.00e-24 103.00
IUUC-Gga-040786 Gallus gallus 29.89 4.00e-24 102.00
IUUC-Gac-041971 Gasterosteus aculeatus 28.98 7.00e-26 108.00
IUUC-Gma-043815 Glycine max 29.97 7.00e-28 115.00
IUUC-Ggo-045138 Gorilla gorilla 27.72 2.00e-17 80.90
IUUC-Hsa-045822 Homo sapiens 32.18 1.00e-27 114.00
IUUC-Hvu-047496 Hordeum vulgare 30.80 1.00e-31 127.00
IUUC-Itr-048022 Ictidomys tridecemlineatus 32.18 5.00e-28 115.00
IUUC-Kpa-049334 Komagataella pastoris 31.71 4.00e-38 149.00
IUUC-Lch-050175 Latimeria chalumnae 29.54 2.00e-26 111.00
IUUC-Lpe-051290 Leersia perrieri 30.80 4.00e-32 129.00
IUUC-Loc-052055 Lepisosteus oculatus 31.44 8.00e-26 108.00
IUUC-Lma-053284 Leptosphaeria maculans 31.48 4.00e-35 139.00
IUUC-Laf-053677 Loxodonta africana 30.85 5.00e-28 116.00
IUUC-Mcc-055371 Macaca mulatta 33.20 3.00e-27 113.00
IUUC-Meu-056786 Macropus eugenii 28.62 4.00e-20 89.70
IUUC-Mor-057062 Magnaporthe oryzae 29.91 2.00e-30 124.00
IUUC-Mpo-057319 Magnaporthe poae 29.00 6.00e-27 112.00
IUUC-Mtr-058159 Medicago truncatula 28.66 6.00e-26 108.00
IUUC-Mla-058998 Melampsora laricipopulina 32.38 5.00e-33 132.00
IUUC-Mga-059715 Meleagris gallopavo 30.10 2.00e-27 114.00
IUUC-Mvi-060498 Microbotryum violaceum 35.90 7.00e-34 135.00
IUUC-Mmr-061604 Microcebus murinus 32.95 1.00e-28 117.00
IUUC-Mdo-062723 Monodelphis domestica 32.14 1.00e-28 117.00
IUUC-Mmu-064423 Mus musculus 34.48 9.00e-28 115.00
IUUC-Mac-064557 Musa acuminata 28.75 1.00e-27 114.00
IUUC-Mpu-065790 Mustela putorius furo 32.18 9.00e-28 115.00
IUUC-Mlu-067323 Myotis lucifugus 32.18 2.00e-27 114.00
IUUC-Nfi-068303 Neosartorya fischeri 32.51 4.00e-28 116.00
IUUC-Ncr-068930 Neurospora crassa 29.03 2.00e-30 124.00
IUUC-Nle-069641 Nomascus leucogenys 32.18 9.00e-28 115.00
IUUC-Opr-070264 Ochotona princeps 28.50 1.00e-09 55.10
IUUC-Ont-072619 Oreochromis niloticus 31.10 3.00e-26 110.00
IUUC-Oan-072871 Ornithorhynchus anatinus 32.32 6.00e-28 115.00
IUUC-Ocu-074116 Oryctolagus cuniculus 29.84 2.00e-18 84.70
IUUC-Oba-075519 Oryza barthii 30.18 1.00e-31 128.00
IUUC-Obr-076026 Oryza brachyantha 30.21 2.00e-31 127.00
IUUC-Ogl-077299 Oryza glaberrima 30.18 1.00e-31 128.00
IUUC-Ogu-078328 Oryza glumaepatula 30.42 1.00e-31 128.00
IUUC-Oin-079058 Oryza indica 30.18 1.00e-31 128.00
IUUC-Olo-080760 Oryza longistaminata 31.37 8.00e-29 119.00
IUUC-Ome-081290 Oryza meridionalis 30.18 1.00e-31 128.00
IUUC-Oni-082116 Oryza nivara 30.00 1.00e-31 128.00
IUUC-Opu-083484 Oryza punctata 30.18 2.00e-31 127.00
IUUC-Oru-085234 Oryza rufipogon 30.00 1.00e-31 128.00
IUUC-Osa-085723 Oryza sativa 30.18 1.00e-31 128.00
IUUC-Ola-087142 Oryzias latipes 31.80 9.00e-27 111.00
IUUC-Olu-087663 Ostreococcus lucimarinus 27.78 7.00e-28 115.00
IUUC-Oga-088511 Otolemur garnettii 32.18 1.00e-27 115.00
IUUC-Oar-090337 Ovis aries 36.36 3.00e-20 90.50
IUUC-Ptr-090829 Pan troglodytes 32.18 7.00e-28 115.00
IUUC-Pan-091853 Papio anubis 31.62 3.00e-24 103.00
IUUC-Psi-093244 Pelodiscus sinensis 33.90 4.00e-27 113.00
IUUC-Pno-094768 Phaeosphaeria nodorum 34.27 1.00e-37 148.00
IUUC-Ppa-095402 Physcomitrella patens 29.77 1.00e-31 127.00
IUUC-Pfo-096308 Poecilia formosa 31.45 1.00e-26 111.00
IUUC-Pab-098622 Pongo abelii 31.56 2.00e-22 97.10
IUUC-Pop-099770 Populus trichocarpa 30.94 5.00e-27 112.00
IUUC-Pca-100732 Procavia capensis 30.96 3.00e-29 120.00
IUUC-Ppe-102094 Prunus persica 31.61 1.00e-33 134.00
IUUC-Pva-103208 Pteropus vampyrus 32.18 8.00e-28 115.00
IUUC-Pgr-103639 Puccinia graminis 28.99 1.00e-22 98.20
IUUC-Ptt-103851 Puccinia triticina 31.58 4.00e-32 129.00
IUUC-Pte-104134 Pyrenophora teres 33.44 1.00e-39 154.00
IUUC-Pyt-104660 Pyrenophora triticirepentis 33.44 1.00e-39 154.00
IUUC-Rno-104826 Rattus norvegicus 32.57 2.00e-28 117.00
IUUC-Sha-107453 Sarcophilus harrisii 32.86 2.00e-29 120.00
IUUC-Sja-107686 Schizosaccharomyces japonicus 33.85 3.00e-36 143.00
IUUC-Spo-108110 Schizosaccharomyces pombe 35.33 1.00e-38 151.00
IUUC-Smo-108765 Selaginella moellendorffii 30.03 2.00e-29 120.00
IUUC-Sit-110416 Setaria italica 30.82 1.00e-33 135.00
IUUC-Sly-111184 Solanum lycopersicum 29.22 6.00e-31 125.00
IUUC-Stu-112187 Solanum tuberosum 29.55 2.00e-31 127.00
IUUC-Sar-113576 Sorex araneus 42.11 9.00e-06 42.00
IUUC-Sbi-114251 Sorghum bicolor 31.27 3.00e-33 133.00
IUUC-Sre-114975 Sporisorium reilianum 35.44 2.00e-40 157.00
IUUC-Ssc-115522 Sus scrofa 32.18 1.00e-27 114.00
IUUC-Tgu-116610 Taeniopygia guttata 32.50 3.00e-28 117.00
IUUC-Tru-118204 Takifugu rubripes 31.58 4.00e-26 110.00
IUUC-Tsy-119153 Tarsius syrichta 25.48 2.00e-11 61.20
IUUC-Tni-119738 Tetraodon nigroviridis 29.93 8.00e-24 102.00
IUUC-Tca-120950 Theobroma cacao 28.99 2.00e-30 124.00
IUUC-Tre-122109 Trichoderma reesei 31.05 6.00e-32 129.00
IUUC-Tvi-122473 Trichoderma virens 29.55 7.00e-29 119.00
IUUC-Tae-123617 Triticum aestivum 30.93 2.00e-32 130.00
IUUC-Tur-126035 Triticum urartu 31.54 7.00e-28 115.00
IUUC-Tme-127040 Tuber melanosporum 31.12 3.00e-33 133.00
IUUC-Tbe-127888 Tupaia belangeri 38.57 3.00e-06 43.90
IUUC-Ttr-128486 Tursiops truncatus 32.18 1.00e-27 115.00
IUUC-Uma-129516 Ustilago maydis 37.54 1.00e-43 168.00
IUUC-Vda-129861 Verticillium dahliae 33.33 5.00e-25 105.00
IUUC-Vpa-130704 Vicugna pacos 27.87 3.00e-18 83.60
IUUC-Vvi-131375 Vitis vinifera 30.62 6.00e-33 132.00
IUUC-Xtr-132795 Xenopus tropicalis 31.10 2.00e-27 114.00
IUUC-Xma-133866 Xiphophorus maculatus 31.45 1.00e-26 111.00
IUUC-Yli-134568 Yarrowia lipolytica 34.03 1.00e-36 144.00
IUUC-Zma-134891 Zea mays 31.43 5.00e-34 136.00
Created Date 25-Jun-2017

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