iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098592

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ABGA01105576

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000016604.2	ENSPPYT00000019309.2	ENSPPYP00000018570.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-67	228.6	253	576

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++k+++  p                                               
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPkatngktqlsgkptnssatelslrsdraeaceregfcwnggasisrs 341
           7******************************7777777777777777888999999999999999999999999999999999999999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 342  leliqnkepSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 421
           99999999989999************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 422  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCTEKgfvplnqtecLLTEMLAKFTETEALE 510
           8999999***************************************************99888************************** PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + 
   Q: 511  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQV 576
           965.*******9999999*******************************997.8889******99865 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRGSLL AVRGQKQDTP VRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTA CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCTCAGAAGT GGTGCTGCTT AGAGTGTGCC ACCACCGAGT CCGTGTGGGC CTGCCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	76.66	0.00e+00	851.00
IUUC-Aca-005278	Anolis carolinensis	77.68	0.00e+00	873.00
IUUC-Bta-012911	Bos taurus	89.27	0.00e+00	919.00
IUUC-Cja-019171	Callithrix jacchus	96.71	0.00e+00	1050.00
IUUC-Cfa-020408	Canis familiaris	89.77	0.00e+00	955.00
IUUC-Cpo-022233	Cavia porcellus	81.65	0.00e+00	858.00
IUUC-Csa-024272	Chlorocebus sabaeus	98.29	0.00e+00	1085.00
IUUC-Cho-025051	Choloepus hoffmanni	88.41	2.00e-156	546.00
IUUC-Dno-029856	Dasypus novemcinctus	90.12	0.00e+00	972.00
IUUC-Ete-032761	Echinops telfairi	79.85	0.00e+00	761.00
IUUC-Eca-033851	Equus caballus	82.01	0.00e+00	845.00
IUUC-Fal-037290	Ficedula albicollis	75.86	0.00e+00	769.00
IUUC-Ggo-044979	Gorilla gorilla	98.44	0.00e+00	1075.00
IUUC-Hsa-046743	Homo sapiens	98.27	0.00e+00	1070.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	91.85	0.00e+00	1009.00
IUUC-Loc-051961	Lepisosteus oculatus	67.16	0.00e+00	647.00
IUUC-Mcc-055048	Macaca mulatta	98.09	0.00e+00	1069.00
IUUC-Meu-055971	Macropus eugenii	66.67	5.00e-147	514.00
IUUC-Mdo-062073	Monodelphis domestica	80.20	0.00e+00	881.00
IUUC-Mmu-064095	Mus musculus	90.99	0.00e+00	995.00
IUUC-Mpu-066318	Mustela putorius furo	93.60	0.00e+00	639.00
IUUC-Mlu-067090	Myotis lucifugus	87.87	0.00e+00	941.00
IUUC-Nle-069486	Nomascus leucogenys	99.13	0.00e+00	1082.00
IUUC-Opr-070563	Ochotona princeps	91.21	0.00e+00	1003.00
IUUC-Ocu-074851	Oryctolagus cuniculus	87.50	0.00e+00	971.00
IUUC-Ola-086413	Oryzias latipes	56.01	3.00e-162	565.00
IUUC-Oga-088862	Otolemur garnettii	92.03	0.00e+00	990.00
IUUC-Ptr-091525	Pan troglodytes	98.44	0.00e+00	1071.00
IUUC-Pan-092363	Papio anubis	98.09	0.00e+00	1065.00
IUUC-Psi-093353	Pelodiscus sinensis	79.08	0.00e+00	864.00
IUUC-Pma-094155	Petromyzon marinus	59.73	8.00e-84	303.00
IUUC-Pca-100449	Procavia capensis	89.48	0.00e+00	983.00
IUUC-Pva-102868	Pteropus vampyrus	89.08	0.00e+00	951.00
IUUC-Rno-105190	Rattus norvegicus	90.64	0.00e+00	1012.00
IUUC-Sha-107337	Sarcophilus harrisii	80.03	0.00e+00	880.00
IUUC-Sar-113561	Sorex araneus	73.74	1.00e-73	270.00
IUUC-Ssc-115735	Sus scrofa	90.12	0.00e+00	940.00
IUUC-Tgu-117025	Taeniopygia guttata	75.81	0.00e+00	782.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence