iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0031187	FBtr0339506	FBpp0308589
FBgn0031187	FBtr0077347	FBpp0077039
FBgn0031187	FBtr0309238	FBpp0301177
FBgn0031187	FBtr0077350	FBpp0077042
FBgn0031187	FBtr0339507	FBpp0308590
FBgn0031187	FBtr0339508	FBpp0308591

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-92	309.6	625	949

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +Gl+N+gNtC+mNSv+QcLs+++el+++l +++ ++      +++++++l++++kl++e+w+ + + v+p el++a++++++++s y+qqDaqEfl+f
   Q: 625  CGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRS----LSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRF 718
           7*****************************9333322....257899*************************************************** PP
   S: 99   lldqleeelkkeknkpkeeeeee.dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesft 195
           +ld+l+++l++  + ++ +  ++ +++++ d  +e  +++++sl+ dlF gqlks++kc +c+n+s++++pf+dls+p+p+++ +   +l+ cL+ f 
   Q: 719  FLDSLHSALNSGVKGETLNIDDNlSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRC---KLEACLDLFI 813
           *********99666666666555144567778***************************************************99...********** PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefp...leLdlspfctspeekqkekkkYeLiavvvHsGsl 290
           +ee l+g+++  c kck +++++k+++++++P++L++hLkRf  se+++s  k+++ vefp    eL++ ++ +++++    ++ Y+L+a+ +H+Gs+
   Q: 814  REEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRF--SETRWS--KLSNIVEFPtsdSELNMGSYGANSNS----NVHYSLYAISNHMGST 903
           ******************************************..776665..9********77556999999988554....789************* PP
   S: 291  ssGHYvayvkn.ekgkWllfdDskVtev.keeevleetgstaYvlfYkr 337
            +GHYva++k+  ++kW +f+D+ V+   +e+  ++   s+aY+lfY+r
   Q: 904  AGGHYVALCKHpVSRKWHEFNDNIVSDAlSENHLVS---SSAYILFYER 949
           ***********44555**********8857888888...********98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MMLDIKKTRG FHKIPQASKL QSTTKTSSVV ATSASSQNEV PSPGGSAGSK VGATNPVRAA 60
NQRFFLVSSY KDPTFLKAEC DLAHAHVTTS KVKTTLQPHR RSRAGEDSRN NNYNTSRAPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGTGACGG TGACTTCGTT TCGGCGTGCG GCCACACTAG CAAAAAAAAT AGGATTAAAA 60
AGTGAGTTCT GTGTTGTGCA AAAAAAAATT GCTTTAATTC GACCGGAAAA AGGCCCTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0002785--P:negative regulation of antimicrobial peptide production
GO:1900425--P:negative regulation of defense response to bacterium
GO:0045824--P:negative regulation of innate immune response
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001988	Ailuropoda melanoleuca	47.63	9.00e-82	296.00
IUUC-Aca-005132	Anolis carolinensis	49.58	9.00e-95	340.00
IUUC-Ago-007959	Ashbya gossypii	33.24	6.00e-48	185.00
IUUC-Acl-008102	Aspergillus clavatus	31.23	6.00e-50	192.00
IUUC-Afl-008604	Aspergillus flavus	31.23	4.00e-49	188.00
IUUC-Ani-009291	Aspergillus nidulans	30.46	7.00e-49	188.00
IUUC-Aor-010098	Aspergillus oryzae	31.23	1.00e-48	187.00
IUUC-Ame-011102	Astyanax mexicanus	48.66	1.00e-84	305.00
IUUC-Bta-012529	Bos taurus	44.91	6.00e-81	294.00
IUUC-Cel-018186	Caenorhabditis elegans	29.79	9.00e-42	164.00
IUUC-Cja-019016	Callithrix jacchus	41.63	2.00e-71	262.00
IUUC-Cfa-020714	Canis familiaris	44.78	2.00e-82	298.00
IUUC-Cpo-021727	Cavia porcellus	47.77	7.00e-81	293.00
IUUC-Csa-023071	Chlorocebus sabaeus	47.49	7.00e-79	286.00
IUUC-Cin-025797	Ciona intestinalis	43.07	3.00e-72	264.00
IUUC-Csv-026132	Ciona savignyi	42.82	2.00e-76	279.00
IUUC-Dre-027476	Danio rerio	49.26	1.00e-75	275.00
IUUC-Dno-029329	Dasypus novemcinctus	48.38	1.00e-90	326.00
IUUC-Dor-030574	Dipodomys ordii	43.92	1.00e-81	296.00
IUUC-Ete-032416	Echinops telfairi	40.30	8.00e-52	197.00
IUUC-Eca-033361	Equus caballus	47.63	1.00e-81	296.00
IUUC-Eeu-035272	Erinaceus europaeus	48.91	3.00e-39	155.00
IUUC-Fca-036497	Felis catus	47.63	4.00e-82	298.00
IUUC-Fal-036766	Ficedula albicollis	49.85	1.00e-85	309.00
IUUC-Gmo-039129	Gadus morhua	46.86	1.00e-80	292.00
IUUC-Gga-040889	Gallus gallus	49.01	5.00e-73	267.00
IUUC-Gac-042475	Gasterosteus aculeatus	46.53	4.00e-82	297.00
IUUC-Ggo-044814	Gorilla gorilla	43.70	1.00e-68	253.00
IUUC-Hsa-045937	Homo sapiens	47.37	3.00e-80	291.00
IUUC-Itr-048171	Ictidomys tridecemlineatus	44.67	1.00e-83	303.00
IUUC-Lch-050527	Latimeria chalumnae	49.11	2.00e-92	332.00
IUUC-Loc-052697	Lepisosteus oculatus	46.49	4.00e-81	295.00
IUUC-Laf-054167	Loxodonta africana	46.94	2.00e-85	309.00
IUUC-Mcc-055584	Macaca mulatta	47.34	2.00e-80	292.00
IUUC-Meu-056542	Macropus eugenii	47.34	3.00e-81	295.00
IUUC-Mga-060020	Meleagris gallopavo	50.45	1.00e-86	312.00
IUUC-Mmr-060989	Microcebus murinus	47.63	6.00e-82	297.00
IUUC-Mdo-062761	Monodelphis domestica	47.34	4.00e-81	294.00
IUUC-Mmu-063710	Mus musculus	47.21	7.00e-82	297.00
IUUC-Mpu-066573	Mustela putorius furo	47.63	4.00e-82	298.00
IUUC-Nle-070013	Nomascus leucogenys	47.96	2.00e-76	279.00
IUUC-Opr-070907	Ochotona princeps	47.49	7.00e-81	293.00
IUUC-Ont-071944	Oreochromis niloticus	48.52	1.00e-86	312.00
IUUC-Oan-073105	Ornithorhynchus anatinus	46.15	2.00e-66	245.00
IUUC-Ocu-073941	Oryctolagus cuniculus	47.34	2.00e-81	296.00
IUUC-Ola-086724	Oryzias latipes	47.46	2.00e-86	311.00
IUUC-Oga-088973	Otolemur garnettii	47.63	4.00e-82	298.00
IUUC-Oar-089916	Ovis aries	44.91	2.00e-88	319.00
IUUC-Ptr-090998	Pan troglodytes	47.37	2.00e-80	292.00
IUUC-Pan-092686	Papio anubis	47.34	1.00e-80	293.00
IUUC-Psi-093216	Pelodiscus sinensis	42.86	4.00e-74	271.00
IUUC-Pfo-097352	Poecilia formosa	48.26	4.00e-90	324.00
IUUC-Pab-098691	Pongo abelii	38.92	5.00e-69	254.00
IUUC-Pca-100205	Procavia capensis	45.24	2.00e-80	292.00
IUUC-Pva-103188	Pteropus vampyrus	47.49	3.00e-79	288.00
IUUC-Pte-104348	Pyrenophora teres	32.33	1.00e-41	164.00
IUUC-Rno-105853	Rattus norvegicus	43.83	2.00e-82	299.00
IUUC-Sce-106435	Saccharomyces cerevisiae	32.97	3.00e-48	186.00
IUUC-Sha-107237	Sarcophilus harrisii	47.34	4.00e-81	295.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	33.43	4.00e-42	165.00
IUUC-Spo-108065	Schizosaccharomyces pombe	31.65	2.00e-37	149.00
IUUC-Smo-108711	Selaginella moellendorffii	33.70	6.00e-42	163.00
IUUC-Sit-109798	Setaria italica	33.23	4.00e-41	162.00
IUUC-Sly-111672	Solanum lycopersicum	33.54	8.00e-37	147.00
IUUC-Sar-113103	Sorex araneus	47.20	2.00e-76	278.00
IUUC-Ssc-115955	Sus scrofa	44.08	5.00e-79	287.00
IUUC-Tgu-116894	Taeniopygia guttata	49.55	2.00e-84	305.00
IUUC-Tru-117703	Takifugu rubripes	46.40	5.00e-77	280.00
IUUC-Tsy-118879	Tarsius syrichta	47.48	1.00e-79	289.00
IUUC-Tni-119866	Tetraodon nigroviridis	49.21	3.00e-85	307.00
IUUC-Tbe-127465	Tupaia belangeri	43.60	1.00e-47	183.00
IUUC-Ttr-128773	Tursiops truncatus	43.00	4.00e-77	281.00
IUUC-Vpa-130402	Vicugna pacos	49.53	4.00e-49	188.00
IUUC-Xtr-132658	Xenopus tropicalis	50.30	9.00e-84	303.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence