iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062075

UUCD1 version

UUC-MoD-00167

Ensembl Protein ID

ENSMODP00000024756.3

UniProt Accession

F6SAI1; F6SAI1_MONDO

Protein Name

Uncharacterized protein

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019837.3	ENSMODT00000025194.3	ENSMODP00000024756.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.10e-07	30.5	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIVKSIRDAGHKCPVDNAILLETQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSLLNCEDSC GTSHPESDCC AGVASACSTG TKDDSVNGST IPGNLPSSLR EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIVKSIRD AGHKCPVDNA ILLETQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAGCCGAG ATCACTTCCT TATTCTTCGC ATCACCAAGA CCAAGCCTAC AACACGCTCT 60
CCACTTACCG GATCCGGGCG AGCCGGGATG GAATTCACCC TGGCAATCCC GAAAAGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

mdo:100010055

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	81.58	0.00e+00	860.00
IUUC-Apl-004062	Anas platyrhynchos	73.50	0.00e+00	828.00
IUUC-Aca-004636	Anolis carolinensis	69.91	0.00e+00	761.00
IUUC-Ame-011682	Astyanax mexicanus	52.71	1.00e-160	560.00
IUUC-Bta-012692	Bos taurus	79.45	0.00e+00	867.00
IUUC-Bdi-014466	Brachypodium distachyon	32.99	5.00e-08	51.60
IUUC-Cja-019426	Callithrix jacchus	79.63	0.00e+00	868.00
IUUC-Cfa-020948	Canis familiaris	80.24	0.00e+00	763.00
IUUC-Cpo-021378	Cavia porcellus	79.08	0.00e+00	851.00
IUUC-Csa-024045	Chlorocebus sabaeus	79.85	0.00e+00	882.00
IUUC-Cho-024973	Choloepus hoffmanni	64.11	3.00e-90	325.00
IUUC-Csv-026300	Ciona savignyi	41.28	9.00e-47	179.00
IUUC-Dre-027557	Danio rerio	55.81	6.00e-168	583.00
IUUC-Dno-030032	Dasypus novemcinctus	74.70	2.00e-127	448.00
IUUC-Dor-030790	Dipodomys ordii	80.37	0.00e+00	874.00
IUUC-Dse-031478	Dothistroma septosporum	25.93	5.00e-11	62.80
IUUC-Dme-031921	Drosophila melanogaster	26.96	1.00e-42	167.00
IUUC-Ete-032952	Echinops telfairi	78.76	2.00e-155	541.00
IUUC-Eca-033924	Equus caballus	76.33	0.00e+00	788.00
IUUC-Eeu-034734	Erinaceus europaeus	75.05	0.00e+00	788.00
IUUC-Fca-036222	Felis catus	75.09	0.00e+00	774.00
IUUC-Fal-036834	Ficedula albicollis	73.22	0.00e+00	729.00
IUUC-Fox-037935	Fusarium oxysporum	29.44	6.00e-20	92.00
IUUC-Gmo-039061	Gadus morhua	60.89	2.00e-84	306.00
IUUC-Ggr-040084	Gaeumannomyces graminis	25.61	5.00e-15	75.90
IUUC-Gga-040599	Gallus gallus	74.50	0.00e+00	838.00
IUUC-Gac-041977	Gasterosteus aculeatus	54.91	5.00e-166	577.00
IUUC-Gma-042951	Glycine max	29.06	1.00e-08	54.30
IUUC-Ggo-044508	Gorilla gorilla	75.87	0.00e+00	812.00
IUUC-Hsa-046349	Homo sapiens	80.41	0.00e+00	908.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	80.56	0.00e+00	886.00
IUUC-Kpa-049242	Komagataella pastoris	42.25	6.00e-08	50.40
IUUC-Lch-049821	Latimeria chalumnae	68.52	0.00e+00	759.00
IUUC-Lpe-051025	Leersia perrieri	27.71	4.00e-06	45.40
IUUC-Loc-051995	Lepisosteus oculatus	60.31	0.00e+00	627.00
IUUC-Laf-054115	Loxodonta africana	78.45	0.00e+00	862.00
IUUC-Mcc-055298	Macaca mulatta	79.67	0.00e+00	879.00
IUUC-Mor-057263	Magnaporthe oryzae	28.09	2.00e-15	77.40
IUUC-Mpo-057517	Magnaporthe poae	28.43	3.00e-14	73.20
IUUC-Mga-059340	Meleagris gallopavo	74.13	0.00e+00	810.00
IUUC-Mvi-060553	Microbotryum violaceum	27.68	6.00e-15	75.50
IUUC-Mmr-061063	Microcebus murinus	79.56	0.00e+00	862.00
IUUC-Mmu-063780	Mus musculus	79.26	0.00e+00	840.00
IUUC-Mpu-065748	Mustela putorius furo	80.29	0.00e+00	868.00
IUUC-Mlu-067888	Myotis lucifugus	79.37	0.00e+00	857.00
IUUC-Nle-069234	Nomascus leucogenys	80.41	0.00e+00	889.00
IUUC-Opr-070393	Ochotona princeps	91.08	1.00e-116	413.00
IUUC-Ont-072459	Oreochromis niloticus	53.53	2.00e-174	605.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.47	0.00e+00	899.00
IUUC-Ocu-074201	Oryctolagus cuniculus	81.18	0.00e+00	882.00
IUUC-Oba-075457	Oryza barthii	25.00	1.00e-07	50.40
IUUC-Ogl-077406	Oryza glaberrima	25.00	1.00e-07	50.80
IUUC-Ogu-078803	Oryza glumaepatula	25.00	2.00e-07	50.40
IUUC-Oin-079307	Oryza indica	25.00	1.00e-07	50.80
IUUC-Olo-080508	Oryza longistaminata	25.60	4.00e-08	52.00
IUUC-Ome-081315	Oryza meridionalis	24.40	8.00e-08	51.60
IUUC-Oru-085055	Oryza rufipogon	25.00	1.00e-07	50.40
IUUC-Osa-085780	Oryza sativa	25.00	9.00e-08	51.20
IUUC-Ola-087319	Oryzias latipes	59.00	7.00e-87	314.00
IUUC-Olu-087748	Ostreococcus lucimarinus	24.52	4.00e-11	62.40
IUUC-Oga-087936	Otolemur garnettii	80.37	0.00e+00	870.00
IUUC-Oar-089379	Ovis aries	79.27	0.00e+00	870.00
IUUC-Ptr-090758	Pan troglodytes	80.41	0.00e+00	884.00
IUUC-Pan-092590	Papio anubis	79.85	0.00e+00	880.00
IUUC-Psi-093948	Pelodiscus sinensis	72.21	0.00e+00	798.00
IUUC-Pma-094434	Petromyzon marinus	42.20	4.00e-125	441.00
IUUC-Pfo-096912	Poecilia formosa	55.36	6.00e-167	580.00
IUUC-Pab-097651	Pongo abelii	80.41	0.00e+00	885.00
IUUC-Pop-099898	Populus trichocarpa	24.16	1.00e-08	53.90
IUUC-Pca-100958	Procavia capensis	78.83	0.00e+00	642.00
IUUC-Ppe-101547	Prunus persica	27.59	2.00e-08	54.70
IUUC-Pva-103247	Pteropus vampyrus	80.95	9.00e-115	407.00
IUUC-Pte-104279	Pyrenophora teres	27.31	9.00e-12	65.90
IUUC-Rno-104994	Rattus norvegicus	77.96	0.00e+00	851.00
IUUC-Sha-106494	Sarcophilus harrisii	89.50	0.00e+00	1009.00
IUUC-Sar-113375	Sorex araneus	79.70	0.00e+00	853.00
IUUC-Sre-115218	Sporisorium reilianum	27.59	1.00e-14	75.10
IUUC-Ssc-115417	Sus scrofa	80.29	0.00e+00	883.00
IUUC-Tgu-117232	Taeniopygia guttata	72.11	0.00e+00	775.00
IUUC-Tru-118321	Takifugu rubripes	54.16	5.00e-169	587.00
IUUC-Tni-120475	Tetraodon nigroviridis	57.52	1.00e-163	569.00
IUUC-Tbe-127719	Tupaia belangeri	70.85	0.00e+00	736.00
IUUC-Ttr-129264	Tursiops truncatus	77.08	1.00e-107	383.00
IUUC-Uma-129620	Ustilago maydis	27.12	9.00e-16	79.00
IUUC-Vpa-130244	Vicugna pacos	77.87	9.00e-112	397.00
IUUC-Vvi-131070	Vitis vinifera	25.66	2.00e-07	50.10
IUUC-Xtr-131948	Xenopus tropicalis	66.19	0.00e+00	733.00
IUUC-Xma-133132	Xiphophorus maculatus	56.58	1.00e-168	586.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence