iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025342

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

EAAA01000712

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000023878.1	ENSCINT00000033162.1	ENSCINP00000030124.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-88	296.7	2034	2486

Active Site

Position(s)	Description	Evidence
2455	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................e 66
           ++ k+ levef gEeg++l G+t+ef++l+++elq+++lg++l ++n    +q++p + +  +                       +
   Q: 2034 AEKKSMLEVEFIGEEGTGL-GPTLEFYSLVAAELQRKELGMWLVDDN---FIQVDPPEVHGMKrfdyyvqksgglfpsplpqnnidQ 2116
           566889*************.**********************88765...455555554433356777778899999999999999* PP
   S: 67   hlklFeflGrllgkalqdgrlldlplsksfykll..................................................... 100
           + klF+flG+ll+k+lqd rl+dlplsk+f+kl+                                                     
   Q: 2117 VVKLFHFLGILLAKCLQDARLIDLPLSKTFLKLMcseqqssaveqsrfptfldilefclndvstscsghfhqikmnlikfgyqcilk 2203
           **********************************66666666666666666666666666666666666666666666666666666 PP
   S: 101  ...............................lgkklsledleevdpelykslkeikenaes.......................... 130
                                          l                            s                          
   Q: 2204 ffisniknmkiitfvillviflliklfrhtfL----------------------------Skllelcdvrdsilcdlsltdvektsq 2262
           66666666666666665555555555555551............................044444444444444444444444444 PP
   S: 131  .............dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviple 204
                        ++e+lgl+++f +s++++++t+   L  +G+ni+ + eN+++Yv+l++++ +k g ++q++af eGfn+v+p++
   Q: 2263 lnelyleyngtkcKVEDLGLTFQFLPSSSVYNYTSYP-LTKEGANIDLNLENARQYVNLTLNFYFKVGLEKQMAAFTEGFNRVFPIS 2348
           4444444445666999********9999988876655.************************************************* PP
   S: 205  llslFteeelellicGe..eeidvedlkketkykggyte....dspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkpr 285
            l lFt+ el l +cG+  ++++ +d+ + t+ + g+t+    +s+++  +++v+++++ +erk fLqF+Tg+s+lP+gG+a+l+pr
   Q: 2349 NLLLFTPDELHLNLCGDqtPQWSRDDVLAYTEPRLGFTKesslNSRGFLHLVNVICDLTGHERKSFLQFATGCSSLPPGGLANLSPR 2435
           *****************445555556666665456665511116789**************************************** PP
   S: 286  lfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           l+++rk d+ d ++Ps+nTC++yLkLP+Ys++ ilke+Ll+A++e kgF+l+
   Q: 2436 LTIVRKvDSGDGSYPSVNTCVHYLKLPDYSTEAILKERLLAATRE-KGFHLN 2486
           ******99999**********************************.****86 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGVGQE RDMQLIALEQ LCMLLLMSDN VDRCFEMCPP RSFLPALCKI 60
FLDETAPDNV VEVAARAMTY YLDVSADCTR RIVAVDGAVK AICNRLSLRL SDDRTNKDLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGATG TAGATCCAGA TACTTTATTG GAATGGCTCC AGATGGGAGT GGGCCAGGAA 60
AGGGACATGC AACTCATTGC ACTGGAACAG CTTTGTATGT TACTTCTGAT GTCTGATAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	52.81	0.00e+00	1306.00
IUUC-Apl-003493	Anas platyrhynchos	52.33	0.00e+00	1301.00
IUUC-Aca-004521	Anolis carolinensis	52.21	0.00e+00	1288.00
IUUC-Ame-011258	Astyanax mexicanus	52.58	0.00e+00	1286.00
IUUC-Bta-012835	Bos taurus	52.74	0.00e+00	1308.00
IUUC-Cel-018153	Caenorhabditis elegans	47.08	2.00e-150	526.00
IUUC-Cja-019174	Callithrix jacchus	51.99	0.00e+00	1282.00
IUUC-Cfa-021115	Canis familiaris	52.30	0.00e+00	1277.00
IUUC-Cpo-022382	Cavia porcellus	49.16	0.00e+00	1145.00
IUUC-Csa-023230	Chlorocebus sabaeus	52.89	0.00e+00	1308.00
IUUC-Cho-024711	Choloepus hoffmanni	42.84	9.00e-176	610.00
IUUC-Csv-026031	Ciona savignyi	72.04	0.00e+00	2234.00
IUUC-Dre-027435	Danio rerio	52.06	0.00e+00	1285.00
IUUC-Dno-029954	Dasypus novemcinctus	52.67	0.00e+00	1295.00
IUUC-Dor-030734	Dipodomys ordii	50.68	0.00e+00	755.00
IUUC-Dme-031739	Drosophila melanogaster	47.71	0.00e+00	1189.00
IUUC-Ete-033192	Echinops telfairi	48.94	0.00e+00	647.00
IUUC-Eca-033434	Equus caballus	52.44	0.00e+00	1292.00
IUUC-Eeu-035031	Erinaceus europaeus	44.39	3.00e-157	547.00
IUUC-Fca-035998	Felis catus	52.69	0.00e+00	1308.00
IUUC-Fal-037468	Ficedula albicollis	51.06	0.00e+00	1285.00
IUUC-Gmo-038495	Gadus morhua	56.02	0.00e+00	844.00
IUUC-Gga-040736	Gallus gallus	52.36	0.00e+00	1289.00
IUUC-Gac-041777	Gasterosteus aculeatus	52.30	0.00e+00	1263.00
IUUC-Ggo-044677	Gorilla gorilla	49.37	0.00e+00	1176.00
IUUC-Hsa-045879	Homo sapiens	52.89	0.00e+00	1308.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	52.89	0.00e+00	1308.00
IUUC-Lch-050444	Latimeria chalumnae	51.75	0.00e+00	1235.00
IUUC-Loc-051986	Lepisosteus oculatus	52.59	0.00e+00	1293.00
IUUC-Laf-054230	Loxodonta africana	52.24	0.00e+00	1280.00
IUUC-Mcc-054787	Macaca mulatta	52.89	0.00e+00	1308.00
IUUC-Meu-056502	Macropus eugenii	39.74	6.00e-134	471.00
IUUC-Mga-059409	Meleagris gallopavo	51.63	0.00e+00	1025.00
IUUC-Mmr-061667	Microcebus murinus	52.43	0.00e+00	1296.00
IUUC-Mdo-061960	Monodelphis domestica	52.74	0.00e+00	1302.00
IUUC-Mmu-063941	Mus musculus	52.54	0.00e+00	1296.00
IUUC-Mpu-065939	Mustela putorius furo	52.89	0.00e+00	1309.00
IUUC-Mlu-068112	Myotis lucifugus	52.74	0.00e+00	1305.00
IUUC-Nle-069001	Nomascus leucogenys	52.89	0.00e+00	1308.00
IUUC-Opr-071222	Ochotona princeps	51.17	0.00e+00	1134.00
IUUC-Ont-072101	Oreochromis niloticus	52.37	0.00e+00	1285.00
IUUC-Oan-072814	Ornithorhynchus anatinus	52.73	0.00e+00	1299.00
IUUC-Ocu-074011	Oryctolagus cuniculus	52.89	0.00e+00	1305.00
IUUC-Ola-086412	Oryzias latipes	52.25	0.00e+00	1277.00
IUUC-Oar-089668	Ovis aries	52.74	0.00e+00	1308.00
IUUC-Ptr-090517	Pan troglodytes	52.17	0.00e+00	1288.00
IUUC-Pan-091849	Papio anubis	50.67	0.00e+00	1217.00
IUUC-Psi-093390	Pelodiscus sinensis	52.32	0.00e+00	1302.00
IUUC-Pma-094628	Petromyzon marinus	48.61	0.00e+00	839.00
IUUC-Pfo-097075	Poecilia formosa	52.91	0.00e+00	1291.00
IUUC-Pab-098176	Pongo abelii	52.89	0.00e+00	1308.00
IUUC-Pca-101123	Procavia capensis	59.90	0.00e+00	646.00
IUUC-Pva-103008	Pteropus vampyrus	54.22	0.00e+00	888.00
IUUC-Rno-105885	Rattus norvegicus	52.96	0.00e+00	1308.00
IUUC-Sha-107048	Sarcophilus harrisii	52.24	0.00e+00	1295.00
IUUC-Sar-113071	Sorex araneus	52.71	0.00e+00	729.00
IUUC-Ssc-115963	Sus scrofa	52.74	0.00e+00	1305.00
IUUC-Tgu-117488	Taeniopygia guttata	55.44	0.00e+00	793.00
IUUC-Tru-118626	Takifugu rubripes	52.55	0.00e+00	1291.00
IUUC-Tsy-119504	Tarsius syrichta	46.49	0.00e+00	901.00
IUUC-Tni-119877	Tetraodon nigroviridis	52.10	0.00e+00	1267.00
IUUC-Tbe-127602	Tupaia belangeri	62.52	0.00e+00	666.00
IUUC-Ttr-128394	Tursiops truncatus	42.87	5.00e-178	618.00
IUUC-Vpa-130280	Vicugna pacos	52.44	0.00e+00	1296.00
IUUC-Xtr-131787	Xenopus tropicalis	53.28	0.00e+00	1325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence