iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045879

UUCD1 version

UUC-HoS-00446

Ensembl Protein ID

ENSP00000450697.1

UniProt Accession

Q9ULT8; D3DS86; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; HECD1_HUMAN

Genbank Protein ID

AAP13073.1; EAW65950.1; EAW65952.1; BAA86445.2; CAB53681.1; AAH11658.2; AAH63686.1

Protein Name

E3 ubiquitin-protein ligase HECTD1; E3 ligase for inhibin receptor; EULIR; HECT domain-containing protein 1; HECT-type E3 ubiquitin transferase HECTD1

Genbank Nucleotide ID

AY254380; AL121808; CH471078; AB032957; AL110222; BC011658; BC063686

Gene Name

HECTD1; KIAA1131

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000092148.12	ENST00000554882.5	ENSP00000451260.1
ENSG00000092148.12	ENST00000553700.5	ENSP00000450697.1
ENSG00000092148.12	ENST00000553957.5	ENSP00000451860.1
ENSG00000092148.12	ENST00000555915.1	ENSP00000450920.1
ENSG00000092148.12	ENST00000557369.1	ENSP00000452233.1
ENSG00000092148.12	ENST00000554471.2	ENSP00000479695.1
ENSG00000092148.12	ENST00000611816.4	ENSP00000484981.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20175895

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	9.40e-124	414.8	2152	2610

Active Site

Position(s)	Description	Evidence
2579	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp.......................e 66
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   glk+p                       +
   Q: 2152 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsdeleR 2240
           6899****************.******************************************988************************ PP
   S: 67   hlklFeflGrllgkalqdgrlldlplsksfykll........................................................ 100
            +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                        
   Q: 2241 ITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsksefild 2330
           **********************************99999999999999999999999999999999999999988888888887777777 PP
   S: 101  .........lgkklsledleevdpelykslkeikenaes..................................dieelgldltfsvseei 147
                    ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+++f++s++i
   Q: 2331 ppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLNFQFCPSSRI 2420
           7777766666668***********************9334455555666777788899999999999*********************** PP
   S: 148  lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket..ky 235
           +g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +++++++e+  +y
   Q: 2421 YGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---QSPSWAAEDiiNY 2506
           ****999.******************************************************************...6666666665555 PP
   S: 236  ...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilke 321
              k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++yLkLPeYss+ei++e
   Q: 2507 tepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVHYLKLPEYSSEEIMRE 2596
           555*************************************************************************************** PP
   S: 322  kLlyAieetkgFels 336
           +Ll+A++e kgF+l+
   Q: 2597 RLLAATME-KGFHLN 2610
           ********.****86 PP

Organism

Homo sapiens

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure.

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATTTGCTC CGCCTCCGCC GGGCTCGGCT GCCCTCGGCA GCTTCCCCGC CTGGCTCTCC 60
CTCGACCCTC CTCCCCTCCC CCTCCCGGTT CGCGATGGAC TGGGCCTCCC CGCCGCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

hsa:25831

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	99.54	0.00e+00	4685.00
IUUC-Apl-003493	Anas platyrhynchos	95.58	0.00e+00	4516.00
IUUC-Aca-004521	Anolis carolinensis	96.59	0.00e+00	2816.00
IUUC-Ame-011258	Astyanax mexicanus	91.32	0.00e+00	2390.00
IUUC-Bta-012835	Bos taurus	99.66	0.00e+00	4702.00
IUUC-Cel-018153	Caenorhabditis elegans	52.31	5.00e-169	590.00
IUUC-Cja-019174	Callithrix jacchus	98.70	0.00e+00	4613.00
IUUC-Cfa-021115	Canis familiaris	99.50	0.00e+00	4646.00
IUUC-Cpo-022382	Cavia porcellus	95.38	0.00e+00	4436.00
IUUC-Csa-023230	Chlorocebus sabaeus	100.00	0.00e+00	4705.00
IUUC-Cho-024711	Choloepus hoffmanni	96.50	0.00e+00	1652.00
IUUC-Cin-025342	Ciona intestinalis	53.48	0.00e+00	1384.00
IUUC-Csv-026031	Ciona savignyi	51.86	0.00e+00	1406.00
IUUC-Dre-027435	Danio rerio	87.10	0.00e+00	4125.00
IUUC-Dno-029954	Dasypus novemcinctus	99.46	0.00e+00	4654.00
IUUC-Dor-030734	Dipodomys ordii	98.17	0.00e+00	1504.00
IUUC-Dme-031739	Drosophila melanogaster	59.66	0.00e+00	1622.00
IUUC-Ete-033192	Echinops telfairi	90.96	0.00e+00	1184.00
IUUC-Eca-033434	Equus caballus	98.97	0.00e+00	4648.00
IUUC-Eeu-035031	Erinaceus europaeus	83.22	0.00e+00	1076.00
IUUC-Fca-035998	Felis catus	98.01	0.00e+00	4580.00
IUUC-Fal-037468	Ficedula albicollis	95.56	0.00e+00	2808.00
IUUC-Gmo-038495	Gadus morhua	90.71	0.00e+00	1367.00
IUUC-Gga-040736	Gallus gallus	97.55	0.00e+00	2822.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.43	0.00e+00	2404.00
IUUC-Ggo-044677	Gorilla gorilla	95.38	0.00e+00	4418.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	99.73	0.00e+00	4697.00
IUUC-Lch-050444	Latimeria chalumnae	92.13	0.00e+00	4213.00
IUUC-Loc-051986	Lepisosteus oculatus	88.29	0.00e+00	4169.00
IUUC-Laf-054230	Loxodonta africana	98.97	0.00e+00	4600.00
IUUC-Mcc-054787	Macaca mulatta	100.00	0.00e+00	4705.00
IUUC-Meu-056502	Macropus eugenii	89.29	0.00e+00	1335.00
IUUC-Mga-059409	Meleagris gallopavo	91.22	0.00e+00	2078.00
IUUC-Mmr-061667	Microcebus murinus	99.08	0.00e+00	4656.00
IUUC-Mdo-061960	Monodelphis domestica	97.36	0.00e+00	4586.00
IUUC-Mmu-063941	Mus musculus	98.32	0.00e+00	4603.00
IUUC-Mpu-065939	Mustela putorius furo	99.66	0.00e+00	4695.00
IUUC-Mlu-068112	Myotis lucifugus	99.23	0.00e+00	4648.00
IUUC-Nle-069001	Nomascus leucogenys	99.92	0.00e+00	4702.00
IUUC-Opr-071222	Ochotona princeps	94.39	0.00e+00	2100.00
IUUC-Ont-072101	Oreochromis niloticus	86.46	0.00e+00	2627.00
IUUC-Oan-072814	Ornithorhynchus anatinus	97.70	0.00e+00	4589.00
IUUC-Ocu-074011	Oryctolagus cuniculus	99.73	0.00e+00	4694.00
IUUC-Ola-086412	Oryzias latipes	91.36	0.00e+00	2400.00
IUUC-Oar-089668	Ovis aries	99.73	0.00e+00	4697.00
IUUC-Ptr-090517	Pan troglodytes	99.35	0.00e+00	4649.00
IUUC-Pan-091849	Papio anubis	97.28	0.00e+00	4531.00
IUUC-Psi-093390	Pelodiscus sinensis	94.26	0.00e+00	2723.00
IUUC-Pma-094628	Petromyzon marinus	83.40	0.00e+00	1582.00
IUUC-Pfo-097075	Poecilia formosa	92.27	0.00e+00	2451.00
IUUC-Pab-098176	Pongo abelii	100.00	0.00e+00	4705.00
IUUC-Pca-101123	Procavia capensis	94.04	0.00e+00	2489.00
IUUC-Pva-103008	Pteropus vampyrus	94.91	0.00e+00	1925.00
IUUC-Rno-105885	Rattus norvegicus	98.97	0.00e+00	4658.00
IUUC-Sha-107048	Sarcophilus harrisii	95.81	0.00e+00	4500.00
IUUC-Sar-113071	Sorex araneus	94.10	0.00e+00	1277.00
IUUC-Ssc-115963	Sus scrofa	99.35	0.00e+00	4676.00
IUUC-Tgu-117167	Taeniopygia guttata	93.86	0.00e+00	2624.00
IUUC-Tru-118626	Takifugu rubripes	92.59	0.00e+00	2470.00
IUUC-Tsy-119504	Tarsius syrichta	96.50	0.00e+00	2305.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.67	0.00e+00	2411.00
IUUC-Tbe-127602	Tupaia belangeri	97.41	0.00e+00	994.00
IUUC-Ttr-128394	Tursiops truncatus	98.76	0.00e+00	3157.00
IUUC-Vpa-130280	Vicugna pacos	98.65	0.00e+00	4450.00
IUUC-Xtr-131787	Xenopus tropicalis	86.65	0.00e+00	2601.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence