iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059409

UUCD1 version

UUC-MeG-00564

Ensembl Protein ID

ENSMGAP00000013076.2

UniProt Accession

G1NII1; G1NII1_MELGA

Protein Name

Uncharacterized protein

Gene Name

HECTD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000012408.2	ENSMGAT00000013978.2	ENSMGAP00000013076.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-123	412.3	2056	2514

Active Site

Position(s)	Description	Evidence
2483	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l++++  d+e++q++   glk+p                     
   Q: 2056 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDDfpDDESRQVDIGGGLKPPgyyvqrscglftapfpqdsde 2141
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2142 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrsdrdlhctesqseasteeghdslsvgsleedsk 2228
           *************************************99999999999999999999999999999999999999988888877777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e ++p+++++lkeik++a +                                  +ie+lgl+
   Q: 2229 sefildppkpkppawFNGILTWEDFELINPHRARFLKEIKDLAIKrrqilsnkslsedekntklqelmlknpsgsgpplSIEDLGLN 2315
           7777777666666666668***********************933445555566777778889999999999*************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++++g t+++ LkpgGe++ Vt++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2316 FQFCPSSKVYGFTAVD-LKPGGEDETVTMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNRVFPMEKLSSFSHEEVQMILCGN---Q 2398
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2399 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2485
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2486 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2514
           ***********************.****86 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGATG TGGACCCAGA CACATTGCTG GAGTGGCTGC AGATGGGTCA GGGAGATGAA 60
AGGGATATGC AGCTAATAGC ACTGGAACAG CTATGCATGC TACTTCTGAT GTCAGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR010606--Mib_Herc2

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000538	Aegilops tauschii	40.22	2.00e-42	167.00
IUUC-Aml-001987	Ailuropoda melanoleuca	90.92	0.00e+00	2078.00
IUUC-Apl-003493	Anas platyrhynchos	93.67	0.00e+00	2161.00
IUUC-Aca-004521	Anolis carolinensis	98.43	0.00e+00	1966.00
IUUC-Ame-011258	Astyanax mexicanus	95.30	0.00e+00	1930.00
IUUC-Bta-012835	Bos taurus	91.22	0.00e+00	2093.00
IUUC-Bdi-014961	Brachypodium distachyon	30.54	7.00e-64	239.00
IUUC-Cel-018153	Caenorhabditis elegans	52.62	4.00e-172	599.00
IUUC-Cja-019174	Callithrix jacchus	91.14	0.00e+00	2084.00
IUUC-Cfa-021115	Canis familiaris	91.29	0.00e+00	2090.00
IUUC-Cpo-022382	Cavia porcellus	90.85	0.00e+00	2080.00
IUUC-Csa-023230	Chlorocebus sabaeus	91.22	0.00e+00	2087.00
IUUC-Cho-024711	Choloepus hoffmanni	90.01	0.00e+00	1534.00
IUUC-Cin-025342	Ciona intestinalis	52.35	0.00e+00	1115.00
IUUC-Csv-026031	Ciona savignyi	50.60	0.00e+00	1078.00
IUUC-Dre-027435	Danio rerio	95.21	0.00e+00	1924.00
IUUC-Dno-029954	Dasypus novemcinctus	91.29	0.00e+00	2088.00
IUUC-Dor-030734	Dipodomys ordii	93.02	0.00e+00	1419.00
IUUC-Dme-031739	Drosophila melanogaster	57.47	0.00e+00	1276.00
IUUC-Ete-033192	Echinops telfairi	90.05	0.00e+00	1177.00
IUUC-Eca-033434	Equus caballus	91.36	0.00e+00	2090.00
IUUC-Eeu-035031	Erinaceus europaeus	82.07	0.00e+00	1066.00
IUUC-Fca-035998	Felis catus	98.16	0.00e+00	1998.00
IUUC-Fal-037468	Ficedula albicollis	96.82	0.00e+00	1947.00
IUUC-Fox-038035	Fusarium oxysporum	29.85	4.00e-59	222.00
IUUC-Gmo-038495	Gadus morhua	91.21	0.00e+00	1372.00
IUUC-Gga-040736	Gallus gallus	99.72	0.00e+00	1963.00
IUUC-Gac-041777	Gasterosteus aculeatus	92.91	0.00e+00	1863.00
IUUC-Ggo-044677	Gorilla gorilla	87.96	0.00e+00	1991.00
IUUC-Hsa-045879	Homo sapiens	91.22	0.00e+00	2087.00
IUUC-Hvu-047700	Hordeum vulgare	39.52	8.00e-44	172.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	91.07	0.00e+00	2085.00
IUUC-Kpa-049098	Komagataella pastoris	37.20	6.00e-35	143.00
IUUC-Lch-050444	Latimeria chalumnae	85.19	0.00e+00	1944.00
IUUC-Loc-051986	Lepisosteus oculatus	96.13	0.00e+00	1924.00
IUUC-Laf-054230	Loxodonta africana	90.80	0.00e+00	2073.00
IUUC-Mcc-054787	Macaca mulatta	91.22	0.00e+00	2087.00
IUUC-Meu-056502	Macropus eugenii	83.73	0.00e+00	1219.00
IUUC-Mla-058870	Melampsora laricipopulina	38.50	6.00e-40	159.00
IUUC-Mmr-061667	Microcebus murinus	91.07	0.00e+00	2085.00
IUUC-Mdo-061960	Monodelphis domestica	91.80	0.00e+00	2091.00
IUUC-Mmu-063941	Mus musculus	90.43	0.00e+00	2059.00
IUUC-Mpu-065939	Mustela putorius furo	91.14	0.00e+00	2086.00
IUUC-Mlu-068112	Myotis lucifugus	90.92	0.00e+00	2052.00
IUUC-Nle-069001	Nomascus leucogenys	91.14	0.00e+00	2086.00
IUUC-Opr-071222	Ochotona princeps	92.54	0.00e+00	1849.00
IUUC-Ont-072101	Oreochromis niloticus	93.83	0.00e+00	1922.00
IUUC-Oan-072814	Ornithorhynchus anatinus	91.43	0.00e+00	2089.00
IUUC-Ocu-074011	Oryctolagus cuniculus	91.07	0.00e+00	2083.00
IUUC-Obr-076915	Oryza brachyantha	30.45	2.00e-62	234.00
IUUC-Ogl-077055	Oryza glaberrima	30.30	4.00e-61	230.00
IUUC-Oin-079256	Oryza indica	30.00	4.00e-59	223.00
IUUC-Olo-080343	Oryza longistaminata	29.84	7.00e-59	223.00
IUUC-Osa-085972	Oryza sativa	30.30	1.00e-60	227.00
IUUC-Ola-086412	Oryzias latipes	93.11	0.00e+00	1887.00
IUUC-Oar-089668	Ovis aries	91.29	0.00e+00	2088.00
IUUC-Ptr-090517	Pan troglodytes	91.22	0.00e+00	2086.00
IUUC-Pan-091849	Papio anubis	90.12	0.00e+00	2046.00
IUUC-Psi-093390	Pelodiscus sinensis	98.34	0.00e+00	1971.00
IUUC-Pma-094628	Petromyzon marinus	82.33	0.00e+00	1308.00
IUUC-Ppa-095264	Physcomitrella patens	29.66	4.00e-68	253.00
IUUC-Pfo-097075	Poecilia formosa	93.09	0.00e+00	1922.00
IUUC-Pab-098176	Pongo abelii	91.22	0.00e+00	2087.00
IUUC-Pca-101123	Procavia capensis	85.44	0.00e+00	1907.00
IUUC-Pva-103008	Pteropus vampyrus	98.63	0.00e+00	1585.00
IUUC-Rno-105885	Rattus norvegicus	90.70	0.00e+00	2075.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.92	6.00e-27	116.00
IUUC-Sha-107048	Sarcophilus harrisii	91.23	0.00e+00	2102.00
IUUC-Spo-108081	Schizosaccharomyces pombe	37.67	5.00e-38	153.00
IUUC-Sit-110717	Setaria italica	29.46	9.00e-62	232.00
IUUC-Sar-113071	Sorex araneus	92.93	0.00e+00	1268.00
IUUC-Sre-114993	Sporisorium reilianum	40.57	4.00e-41	164.00
IUUC-Ssc-115963	Sus scrofa	90.48	0.00e+00	2067.00
IUUC-Tgu-117167	Taeniopygia guttata	92.61	0.00e+00	2168.00
IUUC-Tru-118626	Takifugu rubripes	92.83	0.00e+00	1903.00
IUUC-Tsy-119504	Tarsius syrichta	91.52	0.00e+00	1572.00
IUUC-Tni-119877	Tetraodon nigroviridis	92.56	0.00e+00	1869.00
IUUC-Tca-121574	Theobroma cacao	28.86	2.00e-49	191.00
IUUC-Tae-124019	Triticum aestivum	34.36	8.00e-60	225.00
IUUC-Tur-126730	Triticum urartu	33.81	5.00e-60	226.00
IUUC-Tbe-127602	Tupaia belangeri	89.05	0.00e+00	1021.00
IUUC-Ttr-128394	Tursiops truncatus	91.07	0.00e+00	2095.00
IUUC-Uma-129365	Ustilago maydis	40.09	7.00e-41	163.00
IUUC-Vpa-130280	Vicugna pacos	96.96	0.00e+00	1963.00
IUUC-Vvi-130904	Vitis vinifera	39.85	1.00e-46	181.00
IUUC-Xtr-131787	Xenopus tropicalis	93.69	0.00e+00	2023.00
IUUC-Xma-133497	Xiphophorus maculatus	70.47	0.00e+00	1617.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence