iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	JASPAR	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.70e-10	42.2	38	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklden 68
           +Dv+l vgg+  +ahk+vL a+S +Fy+ f +    +   +   + +  ++  f  ll+F+Yt++l+++
   Q: 38   TDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGLG--VDVLSLPGgPEARGFAPLLDFMYTSRLRLS 104
           7*****************************9988877..688889966*****************9875 PP

Organism

Mus musculus

Functional Description
(View)

Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.

Protein Sequence
(Fasta)

MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS 60
GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCCGGCTG AATAAAGGAG CAGAGACCGA AAGAGGAGAG AGACCCCGCC CCCCTCGAGA 60
AGAGAAGCCG CAGCCCCTGC GGGACAGGGG TAAGAACCAA ACCCTGAGGG TATCAGATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002634--BolA
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0050727--P:regulation of inflammatory response
GO:0042092--P:type 2 immune response

KEGG

mmu:12029

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002419	Ailuropoda melanoleuca	90.11	0.00e+00	706.00
IUUC-Bta-013175	Bos taurus	88.61	0.00e+00	736.00
IUUC-Cja-018749	Callithrix jacchus	88.26	0.00e+00	765.00
IUUC-Cfa-020386	Canis familiaris	88.21	0.00e+00	702.00
IUUC-Csa-023792	Chlorocebus sabaeus	90.74	0.00e+00	755.00
IUUC-Cho-025094	Choloepus hoffmanni	84.64	1.00e-104	372.00
IUUC-Dno-029013	Dasypus novemcinctus	88.63	0.00e+00	735.00
IUUC-Dor-030873	Dipodomys ordii	90.95	0.00e+00	792.00
IUUC-Ete-033032	Echinops telfairi	85.81	4.00e-177	613.00
IUUC-Eca-034190	Equus caballus	90.03	3.00e-160	558.00
IUUC-Fca-036275	Felis catus	85.88	1.00e-134	473.00
IUUC-Gac-042094	Gasterosteus aculeatus	51.77	1.00e-113	403.00
IUUC-Ggo-045349	Gorilla gorilla	90.00	0.00e+00	781.00
IUUC-Hsa-046420	Homo sapiens	90.19	0.00e+00	782.00
IUUC-Itr-048884	Ictidomys tridecemlineatus	88.00	0.00e+00	779.00
IUUC-Laf-053423	Loxodonta africana	88.63	0.00e+00	758.00
IUUC-Mcc-054929	Macaca mulatta	90.95	0.00e+00	753.00
IUUC-Meu-056583	Macropus eugenii	70.00	3.00e-163	568.00
IUUC-Mdo-062982	Monodelphis domestica	82.14	6.00e-93	334.00
IUUC-Mpu-066664	Mustela putorius furo	89.68	0.00e+00	742.00
IUUC-Mlu-067140	Myotis lucifugus	90.13	0.00e+00	731.00
IUUC-Nle-069642	Nomascus leucogenys	89.12	0.00e+00	769.00
IUUC-Opr-070308	Ochotona princeps	86.34	0.00e+00	704.00
IUUC-Ocu-074174	Oryctolagus cuniculus	77.48	2.00e-121	428.00
IUUC-Oga-088996	Otolemur garnettii	51.20	3.00e-130	458.00
IUUC-Oar-090313	Ovis aries	86.50	0.00e+00	729.00
IUUC-Ptr-090601	Pan troglodytes	90.19	0.00e+00	781.00
IUUC-Pan-092651	Papio anubis	90.74	0.00e+00	751.00
IUUC-Pab-098548	Pongo abelii	90.15	0.00e+00	778.00
IUUC-Pca-100214	Procavia capensis	86.11	0.00e+00	712.00
IUUC-Pva-103170	Pteropus vampyrus	75.52	1.00e-165	576.00
IUUC-Rno-105150	Rattus norvegicus	95.80	0.00e+00	836.00
IUUC-Sha-107591	Sarcophilus harrisii	71.04	4.00e-165	574.00
IUUC-Sar-113228	Sorex araneus	79.04	6.00e-179	620.00
IUUC-Ssc-116067	Sus scrofa	88.02	0.00e+00	728.00
IUUC-Tru-117948	Takifugu rubripes	49.30	1.00e-110	393.00
IUUC-Tsy-119245	Tarsius syrichta	86.82	6.00e-172	596.00
IUUC-Tbe-127318	Tupaia belangeri	92.42	0.00e+00	769.00
IUUC-Ttr-128316	Tursiops truncatus	88.94	1.00e-179	622.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence