iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021524

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AAKN02013850

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000015196.3	ENSCPOT00000015343.2	ENSCPOP00000013698.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-58	192.6	742	777
UBD/Beta-Prp	1.80e-91	306.4	612	775

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H +svt ++f +d  ll+s+s Dgt+k+WD+r+ + 
   Q: 742  HLNSVTHCRFsPDdELLASCSADGTLKLWDVRSANE 777
           999********777*****************99765 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghd 137
             h+++v+  +fs+dg+ +++++ D+t++v+  +tg+ +  +k+hed+vl+++fs ++ ++++ s d+ +++w+  tg+ ++ + ++h+
   Q: 612  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEVKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSVTGKLVH-IYDEHT 699
           4466666666666666666666666666666666666666666666666666666666666666666666666666666666.666666 PP
   S: 138  gvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
           + vnc ++  ++   ll+++s+D  ++lWdl+++ +  tl   h +sv++  f+++ + l+s+s dgt+klwd+++ 
   Q: 700  EQVNCCCFTNSSqnLLLATASNDCLLKLWDLNQNYCRNTLIN-HLNSVTHCRFSPDDELLASCSADGTLKLWDVRSA 775
           666665555444323456666666666666666666666664.6666666666666666666666666666666643 PP

Organism

Cavia porcellus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGVLTISEE ERVKNQPSNH QRAATLIKMI 60
LNKDNPSYIS FYNALLREGY KDLAALLHSG MPVFSSSSGK DSASGITSYV TTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCCA AAGCTCGAAA TTGTTTGCTT CAACATAGAG AAGCTCTGGA AAAGGACATC 60
AAAACATCCT ACATCATGGA TCACATGATT AGTGATGGAG TTTTAACAAT ATCAGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	88.18	0.00e+00	2256.00
IUUC-Apl-004201	Anas platyrhynchos	70.10	0.00e+00	1828.00
IUUC-Aca-004638	Anolis carolinensis	68.24	0.00e+00	1812.00
IUUC-Afu-008928	Aspergillus fumigatus	28.88	9.00e-58	219.00
IUUC-Ani-009285	Aspergillus nidulans	25.42	2.00e-68	254.00
IUUC-Ang-009637	Aspergillus niger	25.00	2.00e-29	125.00
IUUC-Ame-011062	Astyanax mexicanus	54.99	0.00e+00	1394.00
IUUC-Bta-012865	Bos taurus	88.23	0.00e+00	2306.00
IUUC-Cja-018815	Callithrix jacchus	79.01	0.00e+00	1993.00
IUUC-Cfa-020222	Canis familiaris	83.60	0.00e+00	2116.00
IUUC-Csa-023861	Chlorocebus sabaeus	88.15	0.00e+00	2276.00
IUUC-Cho-024484	Choloepus hoffmanni	76.16	0.00e+00	1170.00
IUUC-Dre-028006	Danio rerio	53.35	0.00e+00	1274.00
IUUC-Dno-029591	Dasypus novemcinctus	87.83	0.00e+00	2297.00
IUUC-Dor-030237	Dipodomys ordii	73.41	0.00e+00	1058.00
IUUC-Ete-032620	Echinops telfairi	83.39	0.00e+00	1074.00
IUUC-Eca-033569	Equus caballus	88.15	0.00e+00	2280.00
IUUC-Eeu-035354	Erinaceus europaeus	64.45	8.00e-178	617.00
IUUC-Fca-036337	Felis catus	88.40	0.00e+00	2296.00
IUUC-Fal-037077	Ficedula albicollis	69.90	0.00e+00	1815.00
IUUC-Gmo-039687	Gadus morhua	51.01	0.00e+00	941.00
IUUC-Ggr-039828	Gaeumannomyces graminis	24.73	6.00e-44	173.00
IUUC-Gga-040299	Gallus gallus	68.59	0.00e+00	1823.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.52	0.00e+00	1295.00
IUUC-Ggo-045563	Gorilla gorilla	88.47	0.00e+00	2282.00
IUUC-Hsa-046771	Homo sapiens	88.23	0.00e+00	2278.00
IUUC-Lch-050200	Latimeria chalumnae	64.20	0.00e+00	1630.00
IUUC-Loc-052090	Lepisosteus oculatus	58.76	0.00e+00	1517.00
IUUC-Laf-053861	Loxodonta africana	87.36	0.00e+00	2251.00
IUUC-Mcc-055543	Macaca mulatta	88.71	0.00e+00	2285.00
IUUC-Meu-056688	Macropus eugenii	79.31	0.00e+00	2019.00
IUUC-Mga-059243	Meleagris gallopavo	69.19	0.00e+00	1843.00
IUUC-Mmr-061134	Microcebus murinus	83.14	0.00e+00	1942.00
IUUC-Mdo-062913	Monodelphis domestica	78.59	0.00e+00	2033.00
IUUC-Mmu-063811	Mus musculus	86.15	0.00e+00	2256.00
IUUC-Mpu-066780	Mustela putorius furo	88.48	0.00e+00	2259.00
IUUC-Mlu-067276	Myotis lucifugus	87.20	0.00e+00	2266.00
IUUC-Nfi-068459	Neosartorya fischeri	27.49	3.00e-60	227.00
IUUC-Nle-069129	Nomascus leucogenys	88.07	0.00e+00	2271.00
IUUC-Opr-071007	Ochotona princeps	65.57	0.00e+00	1101.00
IUUC-Ont-071348	Oreochromis niloticus	54.85	0.00e+00	1407.00
IUUC-Oan-072717	Ornithorhynchus anatinus	80.19	0.00e+00	2097.00
IUUC-Ocu-074286	Oryctolagus cuniculus	88.22	0.00e+00	1958.00
IUUC-Ola-086895	Oryzias latipes	50.17	0.00e+00	1197.00
IUUC-Oga-088678	Otolemur garnettii	87.83	0.00e+00	2273.00
IUUC-Oar-089359	Ovis aries	87.91	0.00e+00	2294.00
IUUC-Ptr-091062	Pan troglodytes	88.15	0.00e+00	2276.00
IUUC-Pan-092528	Papio anubis	92.10	0.00e+00	1371.00
IUUC-Psi-093430	Pelodiscus sinensis	73.21	0.00e+00	1914.00
IUUC-Pma-094690	Petromyzon marinus	38.43	2.00e-152	532.00
IUUC-Pfo-097204	Poecilia formosa	54.16	0.00e+00	1375.00
IUUC-Pab-097690	Pongo abelii	88.31	0.00e+00	2275.00
IUUC-Pca-100778	Procavia capensis	68.74	0.00e+00	1146.00
IUUC-Pva-102870	Pteropus vampyrus	85.24	0.00e+00	2041.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	28.07	5.00e-62	233.00
IUUC-Rno-104889	Rattus norvegicus	86.07	0.00e+00	2223.00
IUUC-Sha-107465	Sarcophilus harrisii	79.04	0.00e+00	2073.00
IUUC-Sar-113268	Sorex araneus	86.04	0.00e+00	643.00
IUUC-Ssc-115654	Sus scrofa	87.51	0.00e+00	2289.00
IUUC-Tgu-117302	Taeniopygia guttata	69.98	0.00e+00	1825.00
IUUC-Tru-118363	Takifugu rubripes	54.05	0.00e+00	1379.00
IUUC-Tsy-119007	Tarsius syrichta	84.95	0.00e+00	2174.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.79	0.00e+00	1320.00
IUUC-Tur-126636	Triticum urartu	22.41	2.00e-23	105.00
IUUC-Tbe-127413	Tupaia belangeri	75.80	0.00e+00	1399.00
IUUC-Ttr-129213	Tursiops truncatus	81.99	0.00e+00	2093.00
IUUC-Vpa-130146	Vicugna pacos	82.69	0.00e+00	1592.00
IUUC-Xtr-132559	Xenopus tropicalis	61.18	0.00e+00	1570.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence