iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008851.4	ENSCAFT00000014077.4	ENSCAFP00000013022.3
ENSCAFG00000008851.4	ENSCAFT00000014076.3	ENSCAFP00000013021.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-79	268.3	3905	4265

Active Site

Position(s)	Description	Evidence
4239	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3905 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3987
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3988 ADVPLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspegpnkpccrftylTMTG 4072
           ************************9*************56666677799999999999999532..334699*********655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++ ++rl+e + +e+v+a+r+G+  +ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 4073 EEVELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNAECVTAVRAGLGAIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 4159
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 4160 GLMETDQHIEFFWGALETFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 4246
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 4247 QYSSLEIMLEKLRCAIHYR 4265
           ****************986 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGLLLVFPLI QSQSRTDPSL CNITAEVLLN CLRDCQPLSL TKEPADCLNG IETLLCSWLE 60
DTSDTGRHIP HKQKENAAAA LVALACARGS LKTFVHTVHL LQKQTDLGSL PVADVLYRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCTCC TGCTGGTCTT CCCCCTCATT CAGTCCCAGA GCAGAACGGA CCCCTCTCTC 60
TGTAACATAA CTGCTGAGGT GCTATTGAAC TGCCTTCGCG ACTGCCAGCC TTTGAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.57	0.00e+00	7272.00
IUUC-Apl-004161	Anas platyrhynchos	92.56	0.00e+00	5167.00
IUUC-Aca-005341	Anolis carolinensis	88.74	0.00e+00	6623.00
IUUC-Ame-011574	Astyanax mexicanus	81.79	0.00e+00	4880.00
IUUC-Bta-012514	Bos taurus	97.85	0.00e+00	1944.00
IUUC-Cja-019148	Callithrix jacchus	97.02	0.00e+00	5289.00
IUUC-Cpo-021894	Cavia porcellus	96.97	0.00e+00	2764.00
IUUC-Csa-023079	Chlorocebus sabaeus	97.96	0.00e+00	7802.00
IUUC-Cho-024415	Choloepus hoffmanni	92.85	0.00e+00	5074.00
IUUC-Dre-027452	Danio rerio	80.10	0.00e+00	4858.00
IUUC-Dno-029595	Dasypus novemcinctus	97.06	0.00e+00	7750.00
IUUC-Dor-030849	Dipodomys ordii	96.76	0.00e+00	1793.00
IUUC-Ete-032563	Echinops telfairi	90.61	0.00e+00	1614.00
IUUC-Eca-034202	Equus caballus	97.10	0.00e+00	7159.00
IUUC-Eeu-035175	Erinaceus europaeus	97.65	0.00e+00	1081.00
IUUC-Fca-036295	Felis catus	98.41	0.00e+00	7158.00
IUUC-Fal-037003	Ficedula albicollis	92.73	0.00e+00	6714.00
IUUC-Gmo-038579	Gadus morhua	84.80	0.00e+00	2857.00
IUUC-Gga-040961	Gallus gallus	92.89	0.00e+00	7497.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.64	0.00e+00	2890.00
IUUC-Ggo-045099	Gorilla gorilla	97.67	0.00e+00	6417.00
IUUC-Hsa-046331	Homo sapiens	97.81	0.00e+00	7850.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	97.23	0.00e+00	2164.00
IUUC-Lch-049923	Latimeria chalumnae	83.75	0.00e+00	2629.00
IUUC-Loc-052630	Lepisosteus oculatus	84.06	0.00e+00	4040.00
IUUC-Laf-053394	Loxodonta africana	97.48	0.00e+00	7622.00
IUUC-Mcc-055763	Macaca mulatta	97.96	0.00e+00	7809.00
IUUC-Meu-056039	Macropus eugenii	89.04	0.00e+00	5079.00
IUUC-Mga-059500	Meleagris gallopavo	91.37	0.00e+00	6937.00
IUUC-Mmr-060868	Microcebus murinus	94.39	0.00e+00	7528.00
IUUC-Mdo-062772	Monodelphis domestica	94.27	0.00e+00	7601.00
IUUC-Mmu-063606	Mus musculus	96.54	0.00e+00	7745.00
IUUC-Mpu-065860	Mustela putorius furo	95.72	0.00e+00	7146.00
IUUC-Mlu-067376	Myotis lucifugus	96.02	0.00e+00	5348.00
IUUC-Nle-069693	Nomascus leucogenys	95.52	0.00e+00	7618.00
IUUC-Opr-071065	Ochotona princeps	95.25	0.00e+00	1208.00
IUUC-Ont-072470	Oreochromis niloticus	82.38	0.00e+00	4616.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.25	0.00e+00	5193.00
IUUC-Ocu-074032	Oryctolagus cuniculus	96.04	0.00e+00	7735.00
IUUC-Ola-087433	Oryzias latipes	83.08	0.00e+00	1573.00
IUUC-Oga-088546	Otolemur garnettii	97.80	0.00e+00	6972.00
IUUC-Oar-089643	Ovis aries	91.89	0.00e+00	761.00
IUUC-Ptr-090504	Pan troglodytes	96.78	0.00e+00	7294.00
IUUC-Pan-092543	Papio anubis	97.87	0.00e+00	7799.00
IUUC-Psi-093952	Pelodiscus sinensis	89.31	0.00e+00	6819.00
IUUC-Pfo-096356	Poecilia formosa	81.18	0.00e+00	6611.00
IUUC-Pab-098240	Pongo abelii	97.80	0.00e+00	7794.00
IUUC-Pca-100994	Procavia capensis	97.05	0.00e+00	2995.00
IUUC-Pva-102263	Pteropus vampyrus	96.17	0.00e+00	7154.00
IUUC-Rno-104888	Rattus norvegicus	96.44	0.00e+00	7490.00
IUUC-Sha-106944	Sarcophilus harrisii	92.36	0.00e+00	7069.00
IUUC-Sar-113556	Sorex araneus	83.91	0.00e+00	988.00
IUUC-Ssc-116187	Sus scrofa	98.22	0.00e+00	5197.00
IUUC-Tgu-116655	Taeniopygia guttata	92.05	0.00e+00	5111.00
IUUC-Tru-118093	Takifugu rubripes	83.76	0.00e+00	2988.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.28	0.00e+00	1601.00
IUUC-Tbe-127962	Tupaia belangeri	92.21	0.00e+00	1215.00
IUUC-Ttr-128819	Tursiops truncatus	93.54	0.00e+00	2886.00
IUUC-Vpa-130482	Vicugna pacos	94.11	0.00e+00	4450.00
IUUC-Xtr-132222	Xenopus tropicalis	85.98	0.00e+00	6566.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence