iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132614

UUCD1 version

UUC-XeT-00588

Ensembl Protein ID

ENSXETP00000043265.3

UniProt Accession

Q28GC0; Q28GC0_XENTR

Genbank Protein ID

AAI21832.1; CAJ83385.1

Protein Name

Autocrine motility factor receptor; Autocrine motility factor receptor, E3 ubiquitin protein ligase

Genbank Nucleotide ID

AAMC01067006; CR761451

Gene Name

amfr; TGas131p20.1-001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000020020.3	ENSXETT00000043265.3	ENSXETP00000043265.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-08	35.7	333	371
UBD/Alpha-Helix/CUE	6.00e-09	35.9	448	489

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 333  CAICWDSMQS-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 371
           ********99.9*****************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ ++ q+ ++FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 448  QLNAMARQVLDMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 489
           5789999******************.***************95 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MPLLFLERFP WPSLRTYTGL SGLLLGLSLL SAYRSLSGEA AERSMLEGEE AGAQLPPEPV 60
DLVELFRYLV SDSLGVWVLV NTVCCLLMLI AKLIQHVVFG PLRVGERQHL KDKFWNFIFY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGTCCAAA TAGGGCCAGC AGCAAGCGGT GCGAGCTGCT CCCACCCGCG GCGGGCCCTC 60
CCTTCGGTGT GACAGGCCCT TTGGACTAAG GCAAGATGCC GCTGTTATTC CTGGAGCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

xtr:549837

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	78.10	0.00e+00	844.00
IUUC-Apl-003404	Anas platyrhynchos	80.53	0.00e+00	833.00
IUUC-Aca-004559	Anolis carolinensis	77.87	0.00e+00	770.00
IUUC-Ame-011640	Astyanax mexicanus	68.72	0.00e+00	758.00
IUUC-Bta-012980	Bos taurus	74.38	0.00e+00	876.00
IUUC-Cel-018598	Caenorhabditis elegans	25.97	9.00e-34	138.00
IUUC-Cja-019577	Callithrix jacchus	77.27	0.00e+00	919.00
IUUC-Cfa-020793	Canis familiaris	81.36	0.00e+00	855.00
IUUC-Cpo-022387	Cavia porcellus	77.14	0.00e+00	894.00
IUUC-Csa-023168	Chlorocebus sabaeus	77.27	0.00e+00	924.00
IUUC-Cho-024433	Choloepus hoffmanni	81.09	0.00e+00	718.00
IUUC-Cin-025215	Ciona intestinalis	44.19	1.00e-141	496.00
IUUC-Csv-026133	Ciona savignyi	46.06	2.00e-131	462.00
IUUC-Dre-027594	Danio rerio	67.67	0.00e+00	733.00
IUUC-Dno-029407	Dasypus novemcinctus	79.26	0.00e+00	846.00
IUUC-Dor-030961	Dipodomys ordii	80.81	0.00e+00	856.00
IUUC-Ete-032962	Echinops telfairi	74.47	0.00e+00	716.00
IUUC-Eca-033683	Equus caballus	73.44	0.00e+00	858.00
IUUC-Eeu-034515	Erinaceus europaeus	83.70	8.00e-68	251.00
IUUC-Fca-035398	Felis catus	80.27	0.00e+00	830.00
IUUC-Fal-036758	Ficedula albicollis	72.65	0.00e+00	772.00
IUUC-Gmo-039014	Gadus morhua	65.84	0.00e+00	719.00
IUUC-Gga-040575	Gallus gallus	77.05	0.00e+00	901.00
IUUC-Gac-041414	Gasterosteus aculeatus	65.29	0.00e+00	707.00
IUUC-Hsa-046272	Homo sapiens	75.89	0.00e+00	917.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	80.88	0.00e+00	840.00
IUUC-Lch-050491	Latimeria chalumnae	72.43	0.00e+00	810.00
IUUC-Loc-052758	Lepisosteus oculatus	68.34	0.00e+00	777.00
IUUC-Laf-053452	Loxodonta africana	79.32	0.00e+00	855.00
IUUC-Mcc-055820	Macaca mulatta	81.18	0.00e+00	848.00
IUUC-Meu-056726	Macropus eugenii	72.05	0.00e+00	709.00
IUUC-Mga-059937	Meleagris gallopavo	79.25	0.00e+00	840.00
IUUC-Mmr-060730	Microcebus murinus	77.39	0.00e+00	891.00
IUUC-Mdo-062771	Monodelphis domestica	75.69	0.00e+00	901.00
IUUC-Mmu-064219	Mus musculus	76.76	0.00e+00	915.00
IUUC-Mpu-066796	Mustela putorius furo	80.23	0.00e+00	847.00
IUUC-Mlu-068189	Myotis lucifugus	79.21	0.00e+00	834.00
IUUC-Nle-069239	Nomascus leucogenys	77.08	0.00e+00	890.00
IUUC-Opr-070702	Ochotona princeps	70.25	3.00e-105	375.00
IUUC-Ont-072033	Oreochromis niloticus	67.21	0.00e+00	758.00
IUUC-Oan-073717	Ornithorhynchus anatinus	76.25	0.00e+00	764.00
IUUC-Ocu-074145	Oryctolagus cuniculus	76.90	0.00e+00	913.00
IUUC-Ogl-077929	Oryza glaberrima	51.16	1.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	65.74	0.00e+00	741.00
IUUC-Oga-088486	Otolemur garnettii	80.95	0.00e+00	842.00
IUUC-Oar-089310	Ovis aries	80.50	0.00e+00	858.00
IUUC-Ptr-090649	Pan troglodytes	81.54	0.00e+00	868.00
IUUC-Pan-091692	Papio anubis	72.89	0.00e+00	853.00
IUUC-Psi-093064	Pelodiscus sinensis	85.93	0.00e+00	710.00
IUUC-Pma-094763	Petromyzon marinus	75.00	2.00e-92	331.00
IUUC-Ppa-095969	Physcomitrella patens	29.29	9.00e-37	148.00
IUUC-Pfo-096810	Poecilia formosa	67.16	0.00e+00	739.00
IUUC-Pab-097859	Pongo abelii	81.57	0.00e+00	848.00
IUUC-Pca-100344	Procavia capensis	75.25	0.00e+00	866.00
IUUC-Pva-103114	Pteropus vampyrus	52.22	1.00e-150	526.00
IUUC-Rno-105880	Rattus norvegicus	74.58	0.00e+00	865.00
IUUC-Sha-107015	Sarcophilus harrisii	81.42	0.00e+00	867.00
IUUC-Sar-113397	Sorex araneus	85.44	0.00e+00	672.00
IUUC-Ssc-115988	Sus scrofa	73.31	3.00e-106	377.00
IUUC-Tgu-116717	Taeniopygia guttata	76.61	0.00e+00	826.00
IUUC-Tru-117805	Takifugu rubripes	65.34	0.00e+00	763.00
IUUC-Tsy-119442	Tarsius syrichta	75.38	0.00e+00	765.00
IUUC-Tni-119777	Tetraodon nigroviridis	66.90	5.00e-161	560.00
IUUC-Tbe-127322	Tupaia belangeri	57.23	1.00e-94	340.00
IUUC-Ttr-128181	Tursiops truncatus	81.19	0.00e+00	861.00
IUUC-Vpa-130483	Vicugna pacos	74.29	1.00e-165	576.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence