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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046649
UUCD1 version UUC-HoS-00853
Ensembl Protein ID ENSP00000326095.4
UniProt Accession Q96A37; B3KQ03; D3DX75; H3BTU8; Q96DM0; RN166_HUMAN
Genbank Protein ID BAG51865.1; BAB71380.1; EAW66784.1; EAW66781.1; EAW66785.1; AAH13948.1; AAH17226.1; ENSP00000326095
Protein Name RING finger protein 166
Genbank Nucleotide ID AK057106; AK057201; AC138028; CH471184; CH471184; BC013948; BC017226; BI911983
Gene Name RNF166
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000158717.10 ENST00000312838.8 ENSP00000326095.4
ENSG00000158717.10 ENST00000567408.1 ENSP00000455617.1
ENSG00000158717.10 ENST00000562544.1 ENSP00000455539.1
ENSG00000158717.10 ENST00000568683.5 ENSP00000457374.1
ENSG00000158717.10 ENST00000567844.1 ENSP00000457336.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 17990982
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.00e-05 26.2 30 90
E3 activity/RING/RING 5.60e-06 28.4 33 73
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedl.vPnltlrr 63
           ++ CpI le+ + Pv +  +G+t+  ++++ +l+     cP++r p++++++ +  ++ ++
   Q: 30   QYTCPICLEVYHRPVAIGsCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVdKATHVEKQ 90
           689************9877****************************99988666665555 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + +++ +++CgH+f+ +Clq       ++ ++ +CPlCr
   Q: 33   CPICLEVYHRPVAIGSCGHTFCGECLQPC-----LQVPSPLCPLCR 73
           **********999************9444.....799********8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG HTFCGECLQP 60
CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG CNKKVTLAKM RVHISSCLKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046649|UBD,UIM;E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTACGATGAC GTCAGCGCGG CGCAGTAGCG GCTGTGACTA GCGGGCCGGC CCGGGCCAGG 60
ACAGCGGGCG GCGGGCGGCG CGGGCCTGGC CCCGGGATGG CTATGTTCCG CAGCCTGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046649|UBD,UIM;E3,U-box;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX
SMART

SM00184--RING
Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
KEGG hsa:115992
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002042 Ailuropoda melanoleuca 67.33 1.00e-66 246.00
IUUC-Apl-003816 Anas platyrhynchos 70.98 8.00e-75 273.00
IUUC-Aca-005379 Anolis carolinensis 87.69 8.00e-104 369.00
IUUC-Ame-011339 Astyanax mexicanus 89.35 9.00e-91 325.00
IUUC-Bta-012575 Bos taurus 94.12 9.00e-116 409.00
IUUC-Cja-019772 Callithrix jacchus 82.84 1.00e-77 281.00
IUUC-Cfa-021271 Canis familiaris 94.57 2.00e-116 411.00
IUUC-Cpo-022471 Cavia porcellus 98.64 8.00e-130 456.00
IUUC-Csa-023435 Chlorocebus sabaeus 100.00 5.00e-131 459.00
IUUC-Dre-027458 Danio rerio 81.78 1.00e-108 385.00
IUUC-Dor-030798 Dipodomys ordii 98.29 9.00e-67 244.00
IUUC-Eca-033686 Equus caballus 96.45 3.00e-96 343.00
IUUC-Eeu-035051 Erinaceus europaeus 94.12 2.00e-125 441.00
IUUC-Fca-035399 Felis catus 88.95 5.00e-100 356.00
IUUC-Fal-036707 Ficedula albicollis 89.60 1.00e-92 332.00
IUUC-Gga-040346 Gallus gallus 88.72 2.00e-105 375.00
IUUC-Gac-042409 Gasterosteus aculeatus 57.95 1.00e-48 186.00
IUUC-Ggo-045264 Gorilla gorilla 100.00 5.00e-131 459.00
IUUC-Itr-048243 Ictidomys tridecemlineatus 98.22 6.00e-97 345.00
IUUC-Loc-052767 Lepisosteus oculatus 72.62 1.00e-102 365.00
IUUC-Laf-053402 Loxodonta africana 96.83 4.00e-128 450.00
IUUC-Mcc-055236 Macaca mulatta 87.39 1.00e-106 378.00
IUUC-Mga-059430 Meleagris gallopavo 89.71 3.00e-94 337.00
IUUC-Mmr-061214 Microcebus murinus 97.29 3.00e-128 450.00
IUUC-Mdo-062112 Monodelphis domestica 86.38 6.00e-116 409.00
IUUC-Mmu-063307 Mus musculus 98.64 8.00e-130 455.00
IUUC-Mpu-066881 Mustela putorius furo 94.08 9.00e-95 339.00
IUUC-Mlu-067382 Myotis lucifugus 95.27 1.00e-95 342.00
IUUC-Nle-069388 Nomascus leucogenys 94.12 2.00e-120 424.00
IUUC-Oan-072786 Ornithorhynchus anatinus 91.81 1.00e-79 288.00
IUUC-Ola-087498 Oryzias latipes 79.61 6.00e-100 356.00
IUUC-Oga-088354 Otolemur garnettii 88.94 3.00e-123 434.00
IUUC-Oar-090300 Ovis aries 93.98 2.00e-112 397.00
IUUC-Ptr-090594 Pan troglodytes 100.00 5.00e-131 459.00
IUUC-Pan-091714 Papio anubis 100.00 5.00e-131 459.00
IUUC-Psi-093536 Pelodiscus sinensis 91.12 1.00e-92 331.00
IUUC-Pma-094178 Petromyzon marinus 45.92 5.00e-51 193.00
IUUC-Pfo-096266 Poecilia formosa 76.75 5.00e-104 370.00
IUUC-Pab-098752 Pongo abelii 100.00 1.00e-98 352.00
IUUC-Pca-101015 Procavia capensis 96.58 5.00e-66 242.00
IUUC-Pva-102695 Pteropus vampyrus 95.48 2.00e-116 411.00
IUUC-Rno-104836 Rattus norvegicus 98.64 8.00e-130 455.00
IUUC-Sha-106920 Sarcophilus harrisii 81.05 5.00e-115 407.00
IUUC-Tgu-117434 Taeniopygia guttata 90.53 6.00e-92 329.00
IUUC-Tru-118479 Takifugu rubripes 75.42 9.00e-104 369.00
IUUC-Tni-119994 Tetraodon nigroviridis 54.20 4.00e-66 244.00
IUUC-Ttr-129306 Tursiops truncatus 79.19 3.00e-90 324.00
IUUC-Xtr-132746 Xenopus tropicalis 86.73 6.00e-112 396.00
Created Date 25-Jun-2017

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