iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091339

UUCD1 version

UUC-PaT-01082

Ensembl Protein ID

ENSPTRP00000012080.3

UniProt Accession

H2Q9F0; H2Q9F0_PANTR

Genbank Protein ID

JAA44480.1; JAA44481.1; JAA44482.1; JAA44483.1

Protein Name

Ubiquitin specific peptidase 8

Genbank Nucleotide ID

AACZ03098412; GABE01000258; GABE01000257; GABE01000256

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000007065.4	ENSPTRT00000013043.3	ENSPTRP00000012080.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-109	364.7	777	1107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 777  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 863
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 864  YSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
           *********************8855544444444401134566666***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 951  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1032
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1033 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1107
           ***********9988...69*************************88888*******************...********8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGCAAATC GGGAAAAGGG GATGAGCTGG GCTGGCTTCC GTTCTGGTAG CCAAGGCTAA 60
TTCTCCCTCG AGTTCTTGGG AGATGGGCAT TTGGCGAGAA GGCTGGCGTT AGTGAAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:453931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	91.61	0.00e+00	1899.00
IUUC-Apl-003226	Anas platyrhynchos	68.12	0.00e+00	1450.00
IUUC-Aca-004936	Anolis carolinensis	65.27	0.00e+00	1304.00
IUUC-Ago-007959	Ashbya gossypii	35.62	1.00e-54	208.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	9.00e-51	195.00
IUUC-Afl-008604	Aspergillus flavus	32.05	1.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.39	6.00e-50	192.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	9.00e-50	192.00
IUUC-Ang-009844	Aspergillus niger	32.43	6.00e-49	189.00
IUUC-Aor-010098	Aspergillus oryzae	32.05	6.00e-49	189.00
IUUC-Ate-010585	Aspergillus terreus	31.64	5.00e-49	189.00
IUUC-Ame-011029	Astyanax mexicanus	59.23	2.00e-70	258.00
IUUC-Bta-013008	Bos taurus	88.55	0.00e+00	1814.00
IUUC-Bol-015281	Brassica oleracea	38.21	1.00e-46	181.00
IUUC-Bra-017228	Brassica rapa	39.10	1.00e-48	187.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	6.00e-52	199.00
IUUC-Cja-019173	Callithrix jacchus	96.60	0.00e+00	2020.00
IUUC-Cfa-021243	Canis familiaris	91.59	0.00e+00	1904.00
IUUC-Cpo-021522	Cavia porcellus	85.78	0.00e+00	1757.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	2.00e-82	298.00
IUUC-Csa-023616	Chlorocebus sabaeus	97.67	0.00e+00	1725.00
IUUC-Cho-024381	Choloepus hoffmanni	77.65	0.00e+00	1555.00
IUUC-Cin-025287	Ciona intestinalis	50.13	6.00e-99	355.00
IUUC-Csv-026253	Ciona savignyi	48.16	3.00e-87	317.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	2.00e-74	274.00
IUUC-Dre-028440	Danio rerio	68.80	0.00e+00	733.00
IUUC-Dno-029039	Dasypus novemcinctus	90.16	0.00e+00	1924.00
IUUC-Dor-031043	Dipodomys ordii	96.55	1.00e-133	471.00
IUUC-Dse-031463	Dothistroma septosporum	28.36	1.00e-41	165.00
IUUC-Dme-032089	Drosophila melanogaster	44.25	3.00e-84	306.00
IUUC-Ete-033040	Echinops telfairi	81.03	0.00e+00	1529.00
IUUC-Eca-033449	Equus caballus	92.31	0.00e+00	1917.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	6.00e-132	465.00
IUUC-Fca-035794	Felis catus	98.74	0.00e+00	931.00
IUUC-Fal-037322	Ficedula albicollis	69.80	0.00e+00	1452.00
IUUC-Gmo-038584	Gadus morhua	67.14	0.00e+00	664.00
IUUC-Gga-041188	Gallus gallus	83.54	0.00e+00	938.00
IUUC-Gac-041850	Gasterosteus aculeatus	73.05	0.00e+00	746.00
IUUC-Ggo-045565	Gorilla gorilla	99.37	0.00e+00	2095.00
IUUC-Hsa-046438	Homo sapiens	99.55	0.00e+00	2097.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	89.27	0.00e+00	1848.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	9.00e-49	188.00
IUUC-Lch-050485	Latimeria chalumnae	84.31	0.00e+00	866.00
IUUC-Loc-052769	Lepisosteus oculatus	75.15	0.00e+00	773.00
IUUC-Lma-053021	Leptosphaeria maculans	33.04	2.00e-53	204.00
IUUC-Laf-053432	Loxodonta africana	84.81	0.00e+00	1042.00
IUUC-Mcc-055823	Macaca mulatta	98.12	0.00e+00	2078.00
IUUC-Meu-056099	Macropus eugenii	97.03	4.00e-164	572.00
IUUC-Mla-059089	Melampsora laricipopulina	39.88	2.00e-71	264.00
IUUC-Mga-059739	Meleagris gallopavo	83.36	0.00e+00	934.00
IUUC-Mvi-060559	Microbotryum violaceum	40.84	5.00e-77	283.00
IUUC-Mmr-061158	Microcebus murinus	91.41	0.00e+00	1880.00
IUUC-Mdo-061801	Monodelphis domestica	90.71	0.00e+00	1020.00
IUUC-Mmu-063665	Mus musculus	81.66	0.00e+00	1691.00
IUUC-Mpu-066738	Mustela putorius furo	91.59	0.00e+00	1878.00
IUUC-Mlu-067307	Myotis lucifugus	88.04	0.00e+00	1829.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	3.00e-50	194.00
IUUC-Nle-069314	Nomascus leucogenys	98.75	0.00e+00	2078.00
IUUC-Opr-070378	Ochotona princeps	80.59	0.00e+00	1228.00
IUUC-Ont-071545	Oreochromis niloticus	76.88	0.00e+00	766.00
IUUC-Oan-073537	Ornithorhynchus anatinus	75.95	0.00e+00	1531.00
IUUC-Ocu-074193	Oryctolagus cuniculus	88.82	0.00e+00	1848.00
IUUC-Ola-086622	Oryzias latipes	57.27	0.00e+00	1084.00
IUUC-Oga-088271	Otolemur garnettii	89.20	0.00e+00	1845.00
IUUC-Oar-090431	Ovis aries	88.76	0.00e+00	1823.00
IUUC-Pan-091783	Papio anubis	97.21	0.00e+00	1145.00
IUUC-Psi-093187	Pelodiscus sinensis	64.77	0.00e+00	1019.00
IUUC-Pma-094626	Petromyzon marinus	58.43	6.00e-142	496.00
IUUC-Pfo-096463	Poecilia formosa	75.86	0.00e+00	756.00
IUUC-Pab-097645	Pongo abelii	98.93	0.00e+00	2087.00
IUUC-Pva-103222	Pteropus vampyrus	83.02	0.00e+00	941.00
IUUC-Pgr-103408	Puccinia graminis	35.66	1.00e-53	205.00
IUUC-Ptt-103699	Puccinia triticina	45.80	1.00e-67	252.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	7.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	81.22	0.00e+00	1717.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.54	2.00e-51	197.00
IUUC-Sha-106879	Sarcophilus harrisii	89.42	0.00e+00	1009.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.57	4.00e-48	186.00
IUUC-Sar-113019	Sorex araneus	83.27	0.00e+00	1776.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	9.00e-69	255.00
IUUC-Ssc-116334	Sus scrofa	89.11	0.00e+00	1869.00
IUUC-Tgu-117062	Taeniopygia guttata	81.21	0.00e+00	922.00
IUUC-Tru-117908	Takifugu rubripes	57.12	0.00e+00	1156.00
IUUC-Tsy-118867	Tarsius syrichta	88.76	0.00e+00	1107.00
IUUC-Tni-120206	Tetraodon nigroviridis	54.60	0.00e+00	1058.00
IUUC-Tme-127144	Tuber melanosporum	40.00	9.00e-79	288.00
IUUC-Tbe-127877	Tupaia belangeri	88.07	9.00e-107	381.00
IUUC-Ttr-128580	Tursiops truncatus	86.76	0.00e+00	1754.00
IUUC-Uma-129340	Ustilago maydis	35.99	3.00e-71	263.00
IUUC-Vpa-130541	Vicugna pacos	90.25	0.00e+00	1882.00
IUUC-Xtr-132161	Xenopus tropicalis	59.31	0.00e+00	1215.00
IUUC-Xma-134271	Xiphophorus maculatus	75.86	0.00e+00	754.00
IUUC-Yli-134561	Yarrowia lipolytica	36.10	4.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence