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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045909
Ensembl Protein ID ENSP00000352264.5
UniProt Accession Q9Y5K6; A6NL34; Q5VYA3; Q9UG97; CD2AP_HUMAN
Genbank Protein ID AAD34595.1; AAF80495.1; CAH73238.1; CAH73238.1; CAI16839.1; CAI16839.1; EAX04319.1; AAH69444.1; CAB43274.1
Protein Name CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains
Genbank Nucleotide ID AF146277; AF164377; AL355353; AL358178; AL358178; AL355353; CH471081; BC069444; AL050105
Gene Name CD2AP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198087.7 ENST00000359314.5 ENSP00000352264.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 24039852
Classification
Family E-value Score Start End
UBD/SH3 9.10e-67 222.6 270 329
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +ke++++l+ ye++n+deLt+k+G+++++i+ke+ ++gW++g  el+gk+G+fP+nF ++++
   Q: 270  AKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG--ELNGKEGVFPDNFAVQIN 329
           689***************************************..9**************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
 Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Protein Sequence
(Fasta)
MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE 60
TEFKDDSLPI KRERHGNVAS LVQRISTYGL PAGGIQPHPQ TKNIKKKTKK RQCKVLFEYI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045909|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTGTCTGG GTCCCCACCT TAGTCTACGG TGTCGCCTTT TCTAACTGCG AGTGCTAAGG 60
AAGAGGCGAG GGGCGGGCTC CGAGGCTAGG CGGGCGCTCG GGGTTGGAGC CGAGGGTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045909|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
KW-0832--Ubl conjugation
Interpro

IPR028445--CD2AP
IPR001452--SH3_domain
PROSITE

PS50002--SH3
Pfam

PF00018--SH3_1
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030139--C:endocytic vesicle
GO:0070062--C:extracellular exosome
GO:0031941--C:filamentous actin
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0045296--F:cadherin binding
GO:0017124--F:SH3 domain binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0032911--P:negative regulation of transforming growth factor beta1 production
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006461--P:protein complex assembly
GO:2000249--P:regulation of actin cytoskeleton reorganization
GO:0048259--P:regulation of receptor-mediated endocytosis
GO:0007165--P:signal transduction
GO:0016337--P:single organismal cell-cell adhesion
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0016050--P:vesicle organization
KEGG hsa:23607
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001574 Ailuropoda melanoleuca 88.92 0.00e+00 966.00
IUUC-Apl-003573 Anas platyrhynchos 63.32 3.00e-160 558.00
IUUC-Aca-005118 Anolis carolinensis 64.78 2.00e-168 585.00
IUUC-Ame-010657 Astyanax mexicanus 53.26 9.00e-91 327.00
IUUC-Bta-012577 Bos taurus 86.47 0.00e+00 871.00
IUUC-Cja-020010 Callithrix jacchus 93.74 0.00e+00 1002.00
IUUC-Cfa-020040 Canis familiaris 91.38 0.00e+00 956.00
IUUC-Cpo-021906 Cavia porcellus 83.23 0.00e+00 815.00
IUUC-Csa-024008 Chlorocebus sabaeus 95.93 0.00e+00 976.00
IUUC-Cho-024359 Choloepus hoffmanni 73.21 7.00e-61 228.00
IUUC-Csv-026228 Ciona savignyi 40.37 2.00e-24 104.00
IUUC-Dre-027661 Danio rerio 54.76 5.00e-92 332.00
IUUC-Dno-029568 Dasypus novemcinctus 87.83 0.00e+00 879.00
IUUC-Dor-030286 Dipodomys ordii 78.21 0.00e+00 731.00
IUUC-Ete-032576 Echinops telfairi 67.70 1.00e-180 626.00
IUUC-Eca-033438 Equus caballus 90.30 0.00e+00 988.00
IUUC-Eeu-034588 Erinaceus europaeus 73.01 1.00e-152 532.00
IUUC-Fca-036597 Felis catus 90.95 0.00e+00 993.00
IUUC-Fal-037305 Ficedula albicollis 63.74 3.00e-166 578.00
IUUC-Gmo-039516 Gadus morhua 46.33 4.00e-67 249.00
IUUC-Gga-040979 Gallus gallus 66.00 5.00e-180 624.00
IUUC-Gac-041945 Gasterosteus aculeatus 52.03 4.00e-80 292.00
IUUC-Ggo-044488 Gorilla gorilla 99.06 0.00e+00 1042.00
IUUC-Itr-049058 Ictidomys tridecemlineatus 91.17 3.00e-126 444.00
IUUC-Lch-049481 Latimeria chalumnae 55.81 1.00e-156 546.00
IUUC-Loc-052715 Lepisosteus oculatus 51.65 5.00e-143 501.00
IUUC-Laf-053444 Loxodonta africana 86.43 0.00e+00 916.00
IUUC-Mcc-054844 Macaca mulatta 96.24 0.00e+00 978.00
IUUC-Meu-056491 Macropus eugenii 65.44 0.00e+00 632.00
IUUC-Mga-060154 Meleagris gallopavo 66.36 1.00e-179 623.00
IUUC-Mmr-061099 Microcebus murinus 90.61 0.00e+00 918.00
IUUC-Mdo-062769 Monodelphis domestica 71.19 0.00e+00 769.00
IUUC-Mmu-063136 Mus musculus 85.92 0.00e+00 802.00
IUUC-Mpu-066509 Mustela putorius furo 90.37 0.00e+00 893.00
IUUC-Mlu-067174 Myotis lucifugus 86.74 0.00e+00 892.00
IUUC-Nle-070147 Nomascus leucogenys 97.97 0.00e+00 1039.00
IUUC-Opr-070752 Ochotona princeps 84.27 2.00e-174 606.00
IUUC-Ont-071810 Oreochromis niloticus 55.94 3.00e-101 363.00
IUUC-Oan-072731 Ornithorhynchus anatinus 72.94 3.00e-168 585.00
IUUC-Ocu-074331 Oryctolagus cuniculus 90.50 0.00e+00 915.00
IUUC-Ola-086404 Oryzias latipes 46.71 4.00e-91 328.00
IUUC-Oga-088200 Otolemur garnettii 91.08 0.00e+00 1007.00
IUUC-Oar-090423 Ovis aries 85.23 0.00e+00 840.00
IUUC-Ptr-091230 Pan troglodytes 99.37 0.00e+00 1047.00
IUUC-Pan-091823 Papio anubis 95.93 0.00e+00 974.00
IUUC-Psi-093127 Pelodiscus sinensis 63.25 8.00e-164 570.00
IUUC-Pfo-096539 Poecilia formosa 49.56 6.00e-89 322.00
IUUC-Pab-097666 Pongo abelii 98.12 0.00e+00 1023.00
IUUC-Pca-100812 Procavia capensis 82.14 4.00e-132 465.00
IUUC-Pva-102260 Pteropus vampyrus 83.22 0.00e+00 775.00
IUUC-Rno-106038 Rattus norvegicus 84.82 0.00e+00 826.00
IUUC-Sha-106975 Sarcophilus harrisii 72.90 0.00e+00 739.00
IUUC-Sar-113386 Sorex araneus 88.21 1.00e-109 390.00
IUUC-Ssc-115569 Sus scrofa 91.50 2.00e-113 401.00
IUUC-Tgu-117104 Taeniopygia guttata 64.72 5.00e-180 624.00
IUUC-Tru-117649 Takifugu rubripes 51.15 6.00e-97 348.00
IUUC-Tsy-119258 Tarsius syrichta 82.60 0.00e+00 846.00
IUUC-Tni-120755 Tetraodon nigroviridis 45.21 2.00e-123 436.00
IUUC-Tbe-127842 Tupaia belangeri 72.06 0.00e+00 667.00
IUUC-Ttr-129205 Tursiops truncatus 89.55 0.00e+00 815.00
IUUC-Vpa-130434 Vicugna pacos 86.30 0.00e+00 785.00
Created Date 25-Jun-2017

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