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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064161
UUCD1 version UUC-MuM-00030
Ensembl Protein ID ENSMUSP00000049057.6
UniProt Accession Q6PCX9; Q5SX31; Q8CHC5; TRI37_MOUSE
Genbank Protein ID BAC41455.1; BAE24489.1; AAH58678.1; AAH59070.1
Protein Name E3 ubiquitin-protein ligase TRIM37; RING-type E3 ubiquitin transferase TRIM37; Tripartite motif-containing protein 37
Genbank Nucleotide ID AB093271; AK140822; BC058678; BC059070
Gene Name Trim37; Kiaa0898
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000018548.15 ENSMUST00000041282.12 ENSMUSP00000049057.6
ENSMUSG00000018548.15 ENSMUST00000139532.1 ENSMUSP00000119269.1
ENSMUSG00000018548.15 ENSMUST00000154138.1 ENSMUSP00000118260.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 92.44 0.00e+00 1572.00 IUUC-Hsa-046400
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).
 E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042).
Protein Sequence
(Fasta)
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL 60
RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW 120
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Protein Fasta Sequence


>IUUC-Mmu-064161|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CGCGCCTCTA GCTGCCCTGG TTACCGTTGG TGTTTGCGAA TTCTCTGTGG CGCCTGTTCC 60
GCCCCGGACG GGCCCCGCGG CGGTTTTCAC ACGCGCGCGC CGGCGTCACG TGGGCCAGGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064161|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003649--Bbox_C
IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50144--MATH
PS50119--ZF_BBOX
PS50089--ZF_RING_2
Pfam

PF00917--MATH
PF00643--zf-B_box
SMART

SM00502--BBC
SM00336--BBOX
SM00061--MATH
Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0003682--F:chromatin binding
GO:0042803--F:protein homodimerization activity
GO:0005164--F:tumor necrosis factor receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0046600--P:negative regulation of centriole replication
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865--P:protein autoubiquitination
KEGG mmu:68729
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002402 Ailuropoda melanoleuca 93.04 0.00e+00 1599.00
IUUC-Apl-003421 Anas platyrhynchos 76.85 0.00e+00 1259.00
IUUC-Aca-004895 Anolis carolinensis 75.41 0.00e+00 1218.00
IUUC-Aly-005536 Arabidopsis lyrata 30.00 3.00e-08 53.10
IUUC-Ath-007082 Arabidopsis thaliana 29.46 1.00e-08 54.30
IUUC-Ame-011010 Astyanax mexicanus 71.43 0.00e+00 990.00
IUUC-Bta-012395 Bos taurus 90.97 0.00e+00 1454.00
IUUC-Bol-016312 Brassica oleracea 31.01 4.00e-08 52.80
IUUC-Cja-019077 Callithrix jacchus 91.51 0.00e+00 1566.00
IUUC-Cfa-020944 Canis familiaris 91.28 0.00e+00 1551.00
IUUC-Cpo-021701 Cavia porcellus 88.49 0.00e+00 1531.00
IUUC-Csa-023468 Chlorocebus sabaeus 92.12 0.00e+00 1583.00
IUUC-Cho-024941 Choloepus hoffmanni 85.12 0.00e+00 800.00
IUUC-Cin-025184 Ciona intestinalis 71.73 2.00e-171 595.00
IUUC-Csv-026304 Ciona savignyi 64.94 1.00e-59 221.00
IUUC-Dre-027580 Danio rerio 60.83 0.00e+00 993.00
IUUC-Dno-029665 Dasypus novemcinctus 88.78 0.00e+00 1428.00
IUUC-Dor-030509 Dipodomys ordii 68.06 0.00e+00 683.00
IUUC-Ete-032665 Echinops telfairi 74.20 2.00e-165 577.00
IUUC-Eca-034388 Equus caballus 92.00 0.00e+00 1585.00
IUUC-Eeu-034530 Erinaceus europaeus 59.62 3.00e-56 213.00
IUUC-Fca-035842 Felis catus 92.73 0.00e+00 1598.00
IUUC-Fal-037490 Ficedula albicollis 91.67 0.00e+00 944.00
IUUC-Gmo-039700 Gadus morhua 97.47 8.00e-94 337.00
IUUC-Gga-040199 Gallus gallus 76.71 0.00e+00 1245.00
IUUC-Gac-041724 Gasterosteus aculeatus 74.64 0.00e+00 923.00
IUUC-Ggo-045389 Gorilla gorilla 89.27 0.00e+00 1391.00
IUUC-Hsa-046400 Homo sapiens 92.44 0.00e+00 1579.00
IUUC-Itr-048382 Ictidomys tridecemlineatus 91.19 0.00e+00 1572.00
IUUC-Lch-049653 Latimeria chalumnae 68.01 0.00e+00 1080.00
IUUC-Loc-051900 Lepisosteus oculatus 62.17 0.00e+00 990.00
IUUC-Laf-053606 Loxodonta africana 93.06 0.00e+00 1578.00
IUUC-Mcc-054607 Macaca mulatta 92.33 0.00e+00 1590.00
IUUC-Meu-056746 Macropus eugenii 90.61 0.00e+00 793.00
IUUC-Mga-060028 Meleagris gallopavo 77.02 0.00e+00 1251.00
IUUC-Mmr-061345 Microcebus murinus 91.80 0.00e+00 1551.00
IUUC-Mdo-062615 Monodelphis domestica 81.33 0.00e+00 1363.00
IUUC-Mac-065602 Musa acuminata 28.26 3.00e-07 49.30
IUUC-Mpu-066437 Mustela putorius furo 92.43 0.00e+00 1575.00
IUUC-Mlu-068208 Myotis lucifugus 90.16 0.00e+00 1583.00
IUUC-Nle-069104 Nomascus leucogenys 91.42 0.00e+00 1541.00
IUUC-Opr-070233 Ochotona princeps 98.01 4.00e-89 323.00
IUUC-Ont-071969 Oreochromis niloticus 74.24 0.00e+00 942.00
IUUC-Oan-072914 Ornithorhynchus anatinus 69.29 0.00e+00 689.00
IUUC-Ocu-074943 Oryctolagus cuniculus 90.87 0.00e+00 1544.00
IUUC-Oga-088371 Otolemur garnettii 90.98 0.00e+00 1578.00
IUUC-Oar-090383 Ovis aries 91.07 0.00e+00 1493.00
IUUC-Ptr-091450 Pan troglodytes 92.23 0.00e+00 1586.00
IUUC-Pan-091800 Papio anubis 87.72 0.00e+00 931.00
IUUC-Psi-093665 Pelodiscus sinensis 92.61 0.00e+00 920.00
IUUC-Pma-094559 Petromyzon marinus 84.22 0.00e+00 798.00
IUUC-Ppa-095483 Physcomitrella patens 41.59 7.00e-92 332.00
IUUC-Pfo-097163 Poecilia formosa 60.18 1.00e-137 484.00
IUUC-Pab-098742 Pongo abelii 92.19 0.00e+00 1545.00
IUUC-Pop-099648 Populus trichocarpa 31.39 8.00e-07 47.80
IUUC-Pca-100656 Procavia capensis 77.14 0.00e+00 754.00
IUUC-Ppe-101374 Prunus persica 29.86 9.00e-10 57.80
IUUC-Pva-103231 Pteropus vampyrus 80.12 0.00e+00 1118.00
IUUC-Rno-105564 Rattus norvegicus 98.13 0.00e+00 1711.00
IUUC-Smo-109220 Selaginella moellendorffii 35.28 8.00e-88 318.00
IUUC-Sar-112934 Sorex araneus 81.71 0.00e+00 728.00
IUUC-Ssc-116278 Sus scrofa 88.44 0.00e+00 931.00
IUUC-Tgu-117396 Taeniopygia guttata 92.17 0.00e+00 959.00
IUUC-Tru-118296 Takifugu rubripes 75.68 0.00e+00 953.00
IUUC-Tsy-119188 Tarsius syrichta 87.90 0.00e+00 726.00
IUUC-Tni-120147 Tetraodon nigroviridis 74.19 0.00e+00 929.00
IUUC-Tbe-127682 Tupaia belangeri 88.08 0.00e+00 718.00
IUUC-Ttr-129176 Tursiops truncatus 99.32 0.00e+00 858.00
IUUC-Vpa-130336 Vicugna pacos 84.06 0.00e+00 1301.00
IUUC-Vvi-131514 Vitis vinifera 34.88 1.00e-07 50.80
IUUC-Xtr-132646 Xenopus tropicalis 66.80 0.00e+00 1080.00
Created Date 25-Jun-2017

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