iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062975

UUCD1 version

UUC-MoD-00530

Ensembl Protein ID

ENSMODP00000037580.2

UniProt Accession

F7A2Q4; F7A2Q4_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000000974.3	ENSMODT00000039178.2	ENSMODP00000037580.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-108	363.0	551	877

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 551  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 634
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l++
   Q: 635  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKDLLEY-EGSVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVSLYA 721
           *************************************.6677775.999**9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 722  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSLIIREFWEIVHSFTDEQKRLFLQ 810
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 811  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 877
           *****************...8888866666**************************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MATACKRSPG EPHSDDIEAS RMKRAAAKHL IERYYHQLTE GCGNEVCTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGT SSAYLENNSK GAHNNSCTDR KMNKKEVQGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCAGGATTC TGTAGGAGCC TGATTTTAGA ATTCACAAGA TCACCTGAAG TACTAGAGAA 60
AATATGGTAT GTTTATATTT TTAAAAAATT AATATGAAAC TAATATCTCA ATGTCAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	96.61	0.00e+00	1590.00
IUUC-Atr-003144	Amborella trichopoda	45.58	1.00e-95	343.00
IUUC-Apl-003742	Anas platyrhynchos	97.28	0.00e+00	1664.00
IUUC-Aca-004873	Anolis carolinensis	96.38	0.00e+00	1678.00
IUUC-Ame-011166	Astyanax mexicanus	87.18	0.00e+00	1481.00
IUUC-Bta-013286	Bos taurus	94.08	0.00e+00	1576.00
IUUC-Cja-019707	Callithrix jacchus	95.76	0.00e+00	1608.00
IUUC-Cfa-020154	Canis familiaris	94.84	0.00e+00	1603.00
IUUC-Cpo-021292	Cavia porcellus	94.98	0.00e+00	1568.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	7.00e-83	300.00
IUUC-Csa-023378	Chlorocebus sabaeus	95.79	0.00e+00	1614.00
IUUC-Cho-025059	Choloepus hoffmanni	93.00	0.00e+00	1511.00
IUUC-Cin-025643	Ciona intestinalis	44.35	0.00e+00	710.00
IUUC-Csv-026282	Ciona savignyi	44.35	0.00e+00	668.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.47	4.00e-102	366.00
IUUC-Dre-027901	Danio rerio	85.90	0.00e+00	1452.00
IUUC-Dno-029320	Dasypus novemcinctus	96.58	0.00e+00	1638.00
IUUC-Dor-030756	Dipodomys ordii	92.03	0.00e+00	715.00
IUUC-Dme-032035	Drosophila melanogaster	42.96	1.00e-166	580.00
IUUC-Eca-033843	Equus caballus	94.28	0.00e+00	1545.00
IUUC-Eeu-035109	Erinaceus europaeus	94.28	0.00e+00	1530.00
IUUC-Fca-036344	Felis catus	95.22	0.00e+00	1618.00
IUUC-Fal-036747	Ficedula albicollis	97.16	0.00e+00	1661.00
IUUC-Gmo-038840	Gadus morhua	63.33	0.00e+00	1106.00
IUUC-Gga-040399	Gallus gallus	97.16	0.00e+00	1660.00
IUUC-Gac-041933	Gasterosteus aculeatus	85.84	0.00e+00	1424.00
IUUC-Ggo-044804	Gorilla gorilla	95.54	0.00e+00	1603.00
IUUC-Hsa-045727	Homo sapiens	95.54	0.00e+00	1603.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	92.17	0.00e+00	1485.00
IUUC-Lch-050197	Latimeria chalumnae	92.66	0.00e+00	1592.00
IUUC-Loc-052743	Lepisosteus oculatus	90.96	0.00e+00	1577.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	3.00e-57	217.00
IUUC-Laf-053615	Loxodonta africana	95.05	0.00e+00	1605.00
IUUC-Mcc-054934	Macaca mulatta	95.86	0.00e+00	1599.00
IUUC-Meu-056061	Macropus eugenii	99.34	0.00e+00	1395.00
IUUC-Mga-059271	Meleagris gallopavo	95.46	0.00e+00	1618.00
IUUC-Mmr-061288	Microcebus murinus	95.63	0.00e+00	1601.00
IUUC-Mmu-063674	Mus musculus	93.74	0.00e+00	1563.00
IUUC-Mpu-066568	Mustela putorius furo	96.70	0.00e+00	1637.00
IUUC-Mlu-067522	Myotis lucifugus	87.78	0.00e+00	1493.00
IUUC-Nle-069505	Nomascus leucogenys	95.54	0.00e+00	1603.00
IUUC-Opr-070570	Ochotona princeps	87.57	0.00e+00	1432.00
IUUC-Ont-071527	Oreochromis niloticus	87.02	0.00e+00	1487.00
IUUC-Oan-073446	Ornithorhynchus anatinus	92.50	0.00e+00	1103.00
IUUC-Ocu-074922	Oryctolagus cuniculus	93.90	0.00e+00	1609.00
IUUC-Ola-086996	Oryzias latipes	85.48	0.00e+00	1490.00
IUUC-Oga-088261	Otolemur garnettii	95.56	0.00e+00	1576.00
IUUC-Oar-090024	Ovis aries	94.08	0.00e+00	1576.00
IUUC-Ptr-090455	Pan troglodytes	95.54	0.00e+00	1603.00
IUUC-Pan-092509	Papio anubis	93.60	0.00e+00	1432.00
IUUC-Psi-092974	Pelodiscus sinensis	97.05	0.00e+00	1635.00
IUUC-Pma-094643	Petromyzon marinus	70.94	0.00e+00	1258.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.58	2.00e-58	221.00
IUUC-Pfo-096905	Poecilia formosa	85.76	0.00e+00	1491.00
IUUC-Pab-097840	Pongo abelii	93.70	0.00e+00	1533.00
IUUC-Pca-100869	Procavia capensis	96.03	0.00e+00	1595.00
IUUC-Pva-103040	Pteropus vampyrus	96.43	0.00e+00	665.00
IUUC-Rno-105453	Rattus norvegicus	93.51	0.00e+00	1560.00
IUUC-Sha-107651	Sarcophilus harrisii	99.77	0.00e+00	1700.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	4.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	95.80	0.00e+00	1576.00
IUUC-Ssc-115979	Sus scrofa	96.03	0.00e+00	1576.00
IUUC-Tgu-116901	Taeniopygia guttata	97.16	0.00e+00	1662.00
IUUC-Tru-118368	Takifugu rubripes	85.94	0.00e+00	1486.00
IUUC-Tsy-119516	Tarsius syrichta	91.82	0.00e+00	1467.00
IUUC-Tni-120143	Tetraodon nigroviridis	86.64	0.00e+00	1485.00
IUUC-Tbe-127484	Tupaia belangeri	90.27	0.00e+00	1079.00
IUUC-Ttr-129078	Tursiops truncatus	94.05	0.00e+00	1549.00
IUUC-Vpa-130312	Vicugna pacos	86.27	0.00e+00	1324.00
IUUC-Xtr-132881	Xenopus tropicalis	93.58	0.00e+00	1604.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence