iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040969

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000464

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000002781.4	ENSGALT00000004392.3	ENSGALP00000004383.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-07	32.3	24	66
E3 activity/RING/U-box	4.80e-06	26.9	20	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ +k+ p+++ C Hvf++ C  k+  l++++++ ++CPlC+
   Q: 24   CPVCLDVIKE-PVSTKCDHVFCRFCMFKL--LSRKKKGVIQCPLCK 66
           ********99.**************8444..6888**********7 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...tcPvtrqplteedlvPnltlrrliqa 67
           + + Cp+ l++ ++Pv +++ +++ r ++ k l++++k   +cP++++++t+++l+ n   ++li+ 
   Q: 20   KNLECPVCLDVIKEPVSTKCDHVFCRFCMFKLLSRKKKgviQCPLCKTEVTKRSLKENSRFKQLIEG 86
           5688*****************************99999999************************86 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MDLSVIAIGD VQNVLSAMQK NLECPVCLDV IKEPVSTKCD HVFCRFCMFK LLSRKKKGVI 60
QCPLCKTEVT KRSLKENSRF KQLIEGLLEA ISAFELDTGV KFLSSRYFPK TSTEVATAEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAAATGTA ACACGGTAGA GGTGATCGGG TTAGTGGTGC TGGGCGTTTT TATTTGGGCC 60
TTTTCTGCTG CAGAGCTCTG AGATGCTGCC GCGCGATGGC TAAAACGTTT GTCTTTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043009--P:chordate embryonic development
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0071158--P:positive regulation of cell cycle arrest
GO:0035066--P:positive regulation of histone acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	62.98	7.00e-80	293.00
IUUC-Apl-003252	Anas platyrhynchos	62.32	0.00e+00	1511.00
IUUC-Aca-004526	Anolis carolinensis	43.13	2.00e-124	439.00
IUUC-Ame-011720	Astyanax mexicanus	51.23	1.00e-58	222.00
IUUC-Bta-013433	Bos taurus	62.73	1.00e-81	298.00
IUUC-Bol-016476	Brassica oleracea	29.19	4.00e-17	83.60
IUUC-Cel-018208	Caenorhabditis elegans	31.03	2.00e-11	63.90
IUUC-Cja-019149	Callithrix jacchus	52.55	2.00e-78	288.00
IUUC-Cfa-020322	Canis familiaris	59.91	1.00e-78	288.00
IUUC-Cpo-021583	Cavia porcellus	55.86	2.00e-75	277.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	30.99	8.00e-09	54.70
IUUC-Csa-024227	Chlorocebus sabaeus	47.37	4.00e-49	189.00
IUUC-Cho-024530	Choloepus hoffmanni	66.04	3.00e-63	238.00
IUUC-Cin-025364	Ciona intestinalis	40.23	2.00e-14	72.80
IUUC-Csv-026245	Ciona savignyi	37.78	2.00e-12	65.50
IUUC-Dno-029247	Dasypus novemcinctus	26.76	3.00e-32	134.00
IUUC-Ete-032472	Echinops telfairi	44.44	1.00e-60	229.00
IUUC-Eca-033446	Equus caballus	63.46	6.00e-81	296.00
IUUC-Eeu-034858	Erinaceus europaeus	50.77	3.00e-49	191.00
IUUC-Fca-035991	Felis catus	29.84	2.00e-89	324.00
IUUC-Fal-036803	Ficedula albicollis	57.82	0.00e+00	1721.00
IUUC-Gmo-038782	Gadus morhua	47.92	7.00e-47	182.00
IUUC-Gac-042296	Gasterosteus aculeatus	47.95	6.00e-57	216.00
IUUC-Ggo-044740	Gorilla gorilla	47.65	2.00e-69	258.00
IUUC-Hsa-046086	Homo sapiens	62.98	4.00e-74	274.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	60.28	2.00e-77	284.00
IUUC-Lch-049789	Latimeria chalumnae	52.88	3.00e-88	320.00
IUUC-Loc-051952	Lepisosteus oculatus	45.29	2.00e-86	314.00
IUUC-Laf-053648	Loxodonta africana	60.73	4.00e-78	287.00
IUUC-Mcc-055210	Macaca mulatta	30.12	6.00e-94	339.00
IUUC-Meu-056342	Macropus eugenii	50.61	3.00e-43	171.00
IUUC-Mga-060163	Meleagris gallopavo	79.93	0.00e+00	2112.00
IUUC-Mmr-061402	Microcebus murinus	29.64	9.00e-27	114.00
IUUC-Mdo-062209	Monodelphis domestica	62.83	6.00e-84	306.00
IUUC-Mmu-064003	Mus musculus	53.14	1.00e-65	245.00
IUUC-Mpu-065825	Mustela putorius furo	51.99	7.00e-78	285.00
IUUC-Mlu-068176	Myotis lucifugus	60.00	2.00e-73	271.00
IUUC-Nle-069178	Nomascus leucogenys	51.81	4.00e-74	273.00
IUUC-Opr-070574	Ochotona princeps	53.36	2.00e-62	235.00
IUUC-Ont-072380	Oreochromis niloticus	39.42	1.00e-63	238.00
IUUC-Oan-073243	Ornithorhynchus anatinus	63.95	9.00e-30	122.00
IUUC-Ocu-074424	Oryctolagus cuniculus	62.02	1.00e-79	291.00
IUUC-Ola-086863	Oryzias latipes	36.97	1.00e-57	218.00
IUUC-Oar-089938	Ovis aries	65.38	4.00e-81	297.00
IUUC-Ptr-090960	Pan troglodytes	52.17	1.00e-74	275.00
IUUC-Pan-092609	Papio anubis	29.11	6.00e-68	253.00
IUUC-Psi-093889	Pelodiscus sinensis	38.25	3.00e-106	379.00
IUUC-Pfo-096328	Poecilia formosa	38.69	1.00e-61	232.00
IUUC-Pab-097982	Pongo abelii	52.90	1.00e-75	278.00
IUUC-Pca-100698	Procavia capensis	52.13	5.00e-76	280.00
IUUC-Pva-102631	Pteropus vampyrus	61.33	3.00e-75	277.00
IUUC-Ptt-103843	Puccinia triticina	34.85	4.00e-07	48.90
IUUC-Rno-105879	Rattus norvegicus	43.88	1.00e-63	238.00
IUUC-Sha-106701	Sarcophilus harrisii	74.32	8.00e-29	122.00
IUUC-Sit-110609	Setaria italica	26.24	5.00e-16	80.10
IUUC-Sar-113047	Sorex araneus	30.35	4.00e-52	201.00
IUUC-Ssc-115846	Sus scrofa	55.31	4.00e-79	290.00
IUUC-Tgu-116785	Taeniopygia guttata	59.11	0.00e+00	1698.00
IUUC-Tru-117895	Takifugu rubripes	48.86	1.00e-59	225.00
IUUC-Tsy-118885	Tarsius syrichta	50.31	6.00e-34	140.00
IUUC-Tni-119654	Tetraodon nigroviridis	43.38	1.00e-48	189.00
IUUC-Tbe-127421	Tupaia belangeri	54.88	7.00e-49	189.00
IUUC-Ttr-128685	Tursiops truncatus	64.42	7.00e-75	276.00
IUUC-Vpa-130216	Vicugna pacos	53.02	6.00e-80	293.00
IUUC-Vvi-131586	Vitis vinifera	30.70	2.00e-11	65.50
IUUC-Xtr-132398	Xenopus tropicalis	60.48	4.00e-70	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence