iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	8.40e-16	59.2	128	196

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           aDv +vvg     ++ + hk+vLa  SsvF+a+f++el e   k+++ i dv+p +f a+lk++Y++++d+
   Q: 128  ADVHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAED--KDEIRIPDVEPAAFLAMLKYIYCDEIDL 196
           69*****555569***************************8..6************************997 PP

Organism

Mus musculus

Functional Description
(View)

Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed.

Protein Sequence
(Fasta)

MVDDKEKNMK CLTFFLMLPE TVKNRSKKGS KKANSSGGGG GGGSVGSGSS KLPPVCYEII 60
TLKTKKKKKM AADIFPRKKP ANSSSTTVQQ QHQHNLCNNN LIPAPNWQGL YPTIRERNAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGCGCCT CCCGGCCCCT CCTGGCGCTC GGGTGTGCGT TCACGGTCCC GGGGAGCGTG 60
CCCTGCGTGC GGGTGCCCGC CTCGCCCGCC GGGCTCTGGA TCCCTGAGTT CCTGGACCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0021987--P:cerebral cortex development
GO:0048813--P:dendrite morphogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

mmu:228662

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002161	Ailuropoda melanoleuca	96.23	0.00e+00	988.00
IUUC-Apl-003517	Anas platyrhynchos	92.64	0.00e+00	963.00
IUUC-Aca-005304	Anolis carolinensis	95.66	0.00e+00	915.00
IUUC-Ame-010761	Astyanax mexicanus	88.94	0.00e+00	803.00
IUUC-Bta-012570	Bos taurus	95.09	0.00e+00	966.00
IUUC-Bci-013714	Botrytis cinerea	31.68	2.00e-05	43.10
IUUC-Cja-019511	Callithrix jacchus	95.47	0.00e+00	1011.00
IUUC-Cfa-020647	Canis familiaris	98.92	0.00e+00	956.00
IUUC-Cpo-021351	Cavia porcellus	95.68	0.00e+00	1004.00
IUUC-Csa-024059	Chlorocebus sabaeus	98.70	0.00e+00	955.00
IUUC-Cho-025005	Choloepus hoffmanni	95.09	0.00e+00	1004.00
IUUC-Cin-025639	Ciona intestinalis	65.13	5.00e-175	607.00
IUUC-Csv-026142	Ciona savignyi	67.73	1.00e-171	595.00
IUUC-Dre-028307	Danio rerio	86.60	0.00e+00	877.00
IUUC-Dno-029035	Dasypus novemcinctus	97.91	0.00e+00	961.00
IUUC-Dor-030552	Dipodomys ordii	97.99	1.00e-142	499.00
IUUC-Dme-032181	Drosophila melanogaster	68.53	0.00e+00	627.00
IUUC-Ete-032361	Echinops telfairi	92.26	0.00e+00	967.00
IUUC-Eca-034159	Equus caballus	98.54	0.00e+00	973.00
IUUC-Eeu-035112	Erinaceus europaeus	92.47	3.00e-138	485.00
IUUC-Fca-036566	Felis catus	96.04	0.00e+00	1013.00
IUUC-Fal-036746	Ficedula albicollis	96.31	0.00e+00	913.00
IUUC-Gmo-039441	Gadus morhua	83.96	0.00e+00	885.00
IUUC-Gga-040851	Gallus gallus	93.21	0.00e+00	961.00
IUUC-Gac-042237	Gasterosteus aculeatus	85.28	0.00e+00	866.00
IUUC-Ggo-044742	Gorilla gorilla	95.09	0.00e+00	1002.00
IUUC-Hsa-045970	Homo sapiens	95.47	0.00e+00	1002.00
IUUC-Itr-048115	Ictidomys tridecemlineatus	96.42	0.00e+00	1007.00
IUUC-Lch-050181	Latimeria chalumnae	86.63	0.00e+00	909.00
IUUC-Loc-051843	Lepisosteus oculatus	93.93	0.00e+00	872.00
IUUC-Laf-053856	Loxodonta africana	94.15	0.00e+00	974.00
IUUC-Mcc-054976	Macaca mulatta	98.70	0.00e+00	955.00
IUUC-Meu-056720	Macropus eugenii	93.77	0.00e+00	986.00
IUUC-Mga-059773	Meleagris gallopavo	93.21	0.00e+00	961.00
IUUC-Mmr-060616	Microcebus murinus	88.94	0.00e+00	862.00
IUUC-Mdo-062550	Monodelphis domestica	94.34	0.00e+00	970.00
IUUC-Mpu-066911	Mustela putorius furo	98.92	0.00e+00	956.00
IUUC-Mlu-067224	Myotis lucifugus	95.87	0.00e+00	1011.00
IUUC-Nle-069698	Nomascus leucogenys	98.54	0.00e+00	969.00
IUUC-Opr-070684	Ochotona princeps	96.04	0.00e+00	998.00
IUUC-Ont-072550	Oreochromis niloticus	87.92	0.00e+00	884.00
IUUC-Oan-072789	Ornithorhynchus anatinus	94.15	0.00e+00	968.00
IUUC-Ocu-074474	Oryctolagus cuniculus	98.92	0.00e+00	956.00
IUUC-Ola-087257	Oryzias latipes	86.60	0.00e+00	878.00
IUUC-Oga-088423	Otolemur garnettii	96.04	0.00e+00	1004.00
IUUC-Oar-089546	Ovis aries	95.28	0.00e+00	1001.00
IUUC-Ptr-090861	Pan troglodytes	95.47	0.00e+00	1002.00
IUUC-Pan-092637	Papio anubis	98.70	0.00e+00	955.00
IUUC-Psi-093667	Pelodiscus sinensis	96.53	0.00e+00	914.00
IUUC-Pma-094204	Petromyzon marinus	83.59	0.00e+00	683.00
IUUC-Pfo-097155	Poecilia formosa	82.83	0.00e+00	871.00
IUUC-Pab-097700	Pongo abelii	98.54	0.00e+00	969.00
IUUC-Pca-100199	Procavia capensis	95.15	0.00e+00	829.00
IUUC-Pva-102923	Pteropus vampyrus	95.85	0.00e+00	1007.00
IUUC-Rno-105022	Rattus norvegicus	96.79	0.00e+00	990.00
IUUC-Sar-113399	Sorex araneus	95.28	0.00e+00	1003.00
IUUC-Ssc-115621	Sus scrofa	95.66	0.00e+00	1013.00
IUUC-Tgu-116670	Taeniopygia guttata	93.21	0.00e+00	961.00
IUUC-Tru-118366	Takifugu rubripes	84.99	0.00e+00	864.00
IUUC-Tsy-119141	Tarsius syrichta	96.23	0.00e+00	1014.00
IUUC-Tni-120629	Tetraodon nigroviridis	86.04	0.00e+00	874.00
IUUC-Tbe-127769	Tupaia belangeri	85.50	0.00e+00	867.00
IUUC-Vpa-130749	Vicugna pacos	94.91	0.00e+00	999.00
IUUC-Xtr-131984	Xenopus tropicalis	88.11	0.00e+00	878.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence