iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-047012

Ensembl Protein ID

ENSP00000340271.5

UniProt Accession

Q5VWG9; Q05DA0; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8; TAF3_HUMAN

Genbank Protein ID

CAC34475.1; CAH73142.1; CAH73142.1; CAH73142.1; CAH73451.1; CAH73451.1; CAH73451.1; CAI15661.1; CAI15661.1; CAI15661.1; AAH17320.1; AAH45106.1; AAH73884.1; AAH62352.1; CAB56032.1

Protein Name

Transcription initiation factor TFIID subunit 3; 140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit

Genbank Nucleotide ID

AJ292190; AL390294; AL159172; AL353754; AL353754; AL159172; AL390294; AL159172; AL353754; AL390294; BC017320; BC045106; BC073884; BC062352; AL117661

Gene Name

TAF3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165632.7	ENST00000344293.5	ENSP00000340271.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	TRANSFAC	TargetScan
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.10e-09	37.6	867	914

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           +C+ C ++++++  ++ C++C++w+H+ C+++   +  p++ +w+CpkC +
   Q: 867  ICPGCNKPDDGS-PMIGCDDCDDWYHWPCVGIM--TAPPEEMQWFCPKCAN 914
           699999999987.7*******************..45555556******86 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.

Protein Sequence
(Fasta)

MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD 60
PILDDVGEAF QLMGVSLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCGGGAGG CGGAGCGAGT CCAAAATGGC GGCTCTCAGG CTGGCGCGCT CCGTGCTGCT 60
GGGGCTTTGA GGTGGTCGCC GGGGGTCCGG GGGACCCTTT CCCCGCCGCG GAAGCCCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011989--ARM-like
IPR006565--BTP
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF07524--Bromo_TP
PF00628--PHD

SMART

SM00576--BTP
SM00249--PHD

Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005669--C:transcription factor TFIID complex
GO:0008270--F:zinc ion binding
GO:0051457--P:maintenance of protein location in nucleus
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter

KEGG

hsa:83860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003831	Anas platyrhynchos	75.13	2.00e-87	317.00
IUUC-Bta-012541	Bos taurus	87.01	0.00e+00	773.00
IUUC-Cel-018700	Caenorhabditis elegans	55.10	4.00e-14	74.30
IUUC-Cja-019753	Callithrix jacchus	97.35	4.00e-137	482.00
IUUC-Cfa-021153	Canis familiaris	87.13	0.00e+00	956.00
IUUC-Cpo-022178	Cavia porcellus	93.44	0.00e+00	712.00
IUUC-Csa-023797	Chlorocebus sabaeus	98.12	0.00e+00	830.00
IUUC-Cho-024357	Choloepus hoffmanni	89.94	1.00e-83	304.00
IUUC-Cin-025173	Ciona intestinalis	65.28	1.00e-27	115.00
IUUC-Csv-026292	Ciona savignyi	60.00	2.00e-24	107.00
IUUC-Dno-029644	Dasypus novemcinctus	85.38	0.00e+00	723.00
IUUC-Dme-031631	Drosophila melanogaster	37.40	7.00e-24	107.00
IUUC-Eeu-034542	Erinaceus europaeus	81.40	0.00e+00	685.00
IUUC-Fca-035867	Felis catus	89.68	1.00e-162	566.00
IUUC-Fal-037442	Ficedula albicollis	76.78	0.00e+00	644.00
IUUC-Gga-041093	Gallus gallus	77.38	2.00e-175	609.00
IUUC-Gac-041347	Gasterosteus aculeatus	44.57	2.00e-88	320.00
IUUC-Itr-048120	Ictidomys tridecemlineatus	85.81	0.00e+00	916.00
IUUC-Lch-049593	Latimeria chalumnae	64.12	1.00e-72	268.00
IUUC-Loc-052228	Lepisosteus oculatus	90.91	4.00e-43	167.00
IUUC-Laf-054492	Loxodonta africana	86.74	0.00e+00	786.00
IUUC-Mcc-054754	Macaca mulatta	98.03	0.00e+00	807.00
IUUC-Mmr-061146	Microcebus murinus	93.37	0.00e+00	789.00
IUUC-Mdo-062034	Monodelphis domestica	86.74	0.00e+00	714.00
IUUC-Mmu-063928	Mus musculus	82.06	0.00e+00	902.00
IUUC-Mpu-066634	Mustela putorius furo	88.69	0.00e+00	745.00
IUUC-Mlu-067116	Myotis lucifugus	83.76	0.00e+00	627.00
IUUC-Nle-069177	Nomascus leucogenys	89.13	0.00e+00	779.00
IUUC-Opr-070692	Ochotona princeps	100.00	8.00e-79	288.00
IUUC-Oan-073680	Ornithorhynchus anatinus	81.97	8.00e-147	514.00
IUUC-Ocu-074944	Oryctolagus cuniculus	86.91	0.00e+00	1011.00
IUUC-Olu-087787	Ostreococcus lucimarinus	39.66	2.00e-07	51.60
IUUC-Oga-088921	Otolemur garnettii	85.28	0.00e+00	1015.00
IUUC-Oar-089568	Ovis aries	84.88	0.00e+00	657.00
IUUC-Ptr-090531	Pan troglodytes	99.71	0.00e+00	854.00
IUUC-Pan-092733	Papio anubis	98.52	0.00e+00	811.00
IUUC-Psi-093411	Pelodiscus sinensis	79.78	1.00e-160	560.00
IUUC-Pma-094511	Petromyzon marinus	43.90	2.00e-29	124.00
IUUC-Pfo-096336	Poecilia formosa	55.03	3.00e-91	330.00
IUUC-Pab-098458	Pongo abelii	97.25	0.00e+00	815.00
IUUC-Pva-102128	Pteropus vampyrus	85.55	0.00e+00	740.00
IUUC-Rno-105180	Rattus norvegicus	81.77	0.00e+00	915.00
IUUC-Sha-107070	Sarcophilus harrisii	76.27	1.00e-108	387.00
IUUC-Ssc-115657	Sus scrofa	86.51	6.00e-134	471.00
IUUC-Tgu-117228	Taeniopygia guttata	76.24	0.00e+00	785.00
IUUC-Tru-117787	Takifugu rubripes	53.00	3.00e-102	366.00
IUUC-Tni-119879	Tetraodon nigroviridis	49.44	9.00e-103	368.00
IUUC-Tbe-127747	Tupaia belangeri	83.50	0.00e+00	830.00
IUUC-Ttr-128397	Tursiops truncatus	70.80	2.00e-99	356.00
IUUC-Xtr-132570	Xenopus tropicalis	69.04	3.00e-158	552.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence