iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048386

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01059560

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000007860.2	ENSSTOT00000007872.2	ENSSTOP00000007045.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	6.40e-40	136.8	93	262
UBD/ZnF/ZnF_A20	1.40e-24	85.8	757	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+ q+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++        +de++++ k+++++   
   Q: 93   VALKTNGDGNCLMHAACQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLIKMASTDtpa 181
           789**********************************************9************************************665 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a++       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  ARSglqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 262
           55269999***********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k++C++ +C+++Gn ++ngyC++C++++++++
   Q: 757  PPKQRCRApACDHFGNTKCNGYCNECFQFKQMYG 790
           9*******************************96 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHKALID RSIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAACQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTAATCTC TGGGGCCAGC TAGTATCCTG GGAGTAGAGG TGACTAAGAT CTTTTGCCTA 60
CAGATTAGGG TAAGGACAAG ATCAAACACC GGGGTTTCCT GCAGGCAGGT ACATAGGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	91.01	0.00e+00	1499.00
IUUC-Apl-003501	Anas platyrhynchos	65.83	0.00e+00	1039.00
IUUC-Aca-004245	Anolis carolinensis	63.81	0.00e+00	1062.00
IUUC-Ame-011789	Astyanax mexicanus	46.35	0.00e+00	695.00
IUUC-Bta-012664	Bos taurus	86.08	0.00e+00	1371.00
IUUC-Cja-019895	Callithrix jacchus	91.77	0.00e+00	1503.00
IUUC-Cfa-020754	Canis familiaris	90.89	0.00e+00	1501.00
IUUC-Cpo-021780	Cavia porcellus	90.91	0.00e+00	1485.00
IUUC-Csa-023568	Chlorocebus sabaeus	92.66	0.00e+00	1528.00
IUUC-Cho-024300	Choloepus hoffmanni	89.50	0.00e+00	651.00
IUUC-Cme-027299	Cyanidioschyzon merolae	28.77	3.80e-01	29.30
IUUC-Dre-028577	Danio rerio	48.63	0.00e+00	685.00
IUUC-Dno-029382	Dasypus novemcinctus	83.04	0.00e+00	1340.00
IUUC-Dor-030874	Dipodomys ordii	88.61	0.00e+00	1439.00
IUUC-Ete-032721	Echinops telfairi	91.63	0.00e+00	805.00
IUUC-Eca-033596	Equus caballus	87.09	0.00e+00	1411.00
IUUC-Eeu-035159	Erinaceus europaeus	87.10	0.00e+00	1129.00
IUUC-Fca-035847	Felis catus	91.65	0.00e+00	1506.00
IUUC-Fal-036681	Ficedula albicollis	64.39	0.00e+00	1050.00
IUUC-Gmo-038521	Gadus morhua	58.82	2.00e-147	515.00
IUUC-Gga-040975	Gallus gallus	63.82	0.00e+00	1052.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.30	5.00e-154	538.00
IUUC-Ggo-045258	Gorilla gorilla	92.28	0.00e+00	1524.00
IUUC-Hsa-046071	Homo sapiens	92.41	0.00e+00	1526.00
IUUC-Lch-050326	Latimeria chalumnae	57.47	0.00e+00	919.00
IUUC-Loc-051945	Lepisosteus oculatus	46.45	1.00e-177	616.00
IUUC-Laf-053722	Loxodonta africana	88.99	0.00e+00	1446.00
IUUC-Mcc-055503	Macaca mulatta	92.15	0.00e+00	1521.00
IUUC-Meu-056481	Macropus eugenii	75.70	0.00e+00	1192.00
IUUC-Mga-059690	Meleagris gallopavo	61.46	0.00e+00	959.00
IUUC-Mmr-061233	Microcebus murinus	90.78	0.00e+00	1458.00
IUUC-Mdo-062446	Monodelphis domestica	79.92	0.00e+00	1301.00
IUUC-Mmu-063436	Mus musculus	88.61	0.00e+00	1428.00
IUUC-Mpu-066808	Mustela putorius furo	91.01	0.00e+00	1497.00
IUUC-Mlu-067339	Myotis lucifugus	90.63	0.00e+00	1460.00
IUUC-Nle-069888	Nomascus leucogenys	92.41	0.00e+00	1526.00
IUUC-Opr-070303	Ochotona princeps	88.78	0.00e+00	1441.00
IUUC-Ont-072283	Oreochromis niloticus	58.55	9.00e-149	520.00
IUUC-Oan-072925	Ornithorhynchus anatinus	76.69	0.00e+00	1250.00
IUUC-Ocu-073889	Oryctolagus cuniculus	90.64	0.00e+00	1444.00
IUUC-Ola-087417	Oryzias latipes	59.13	5.00e-149	521.00
IUUC-Oga-088708	Otolemur garnettii	87.22	0.00e+00	1376.00
IUUC-Oar-089271	Ovis aries	86.71	0.00e+00	1390.00
IUUC-Ptr-091296	Pan troglodytes	92.41	0.00e+00	1525.00
IUUC-Pan-092474	Papio anubis	92.28	0.00e+00	1524.00
IUUC-Psi-093447	Pelodiscus sinensis	68.85	0.00e+00	1119.00
IUUC-Pfo-096511	Poecilia formosa	59.38	1.00e-150	526.00
IUUC-Pab-098700	Pongo abelii	92.41	0.00e+00	1525.00
IUUC-Pca-100246	Procavia capensis	75.95	0.00e+00	1195.00
IUUC-Pva-102606	Pteropus vampyrus	78.17	2.00e-179	622.00
IUUC-Rno-105818	Rattus norvegicus	89.38	0.00e+00	1461.00
IUUC-Sha-106559	Sarcophilus harrisii	79.17	0.00e+00	1281.00
IUUC-Sit-110516	Setaria italica	42.86	8.20e-02	33.10
IUUC-Sar-113454	Sorex araneus	93.90	0.00e+00	649.00
IUUC-Ssc-116064	Sus scrofa	88.61	0.00e+00	1415.00
IUUC-Tgu-117212	Taeniopygia guttata	64.43	0.00e+00	1043.00
IUUC-Tru-118230	Takifugu rubripes	59.42	1.00e-151	530.00
IUUC-Tsy-119066	Tarsius syrichta	88.10	0.00e+00	1448.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.06	0.00e+00	673.00
IUUC-Tur-126383	Triticum urartu	50.00	9.00e-03	31.20
IUUC-Tbe-127601	Tupaia belangeri	96.65	0.00e+00	672.00
IUUC-Ttr-128930	Tursiops truncatus	86.84	0.00e+00	1406.00
IUUC-Vpa-130450	Vicugna pacos	94.76	0.00e+00	799.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence