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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032170
UUCD1 version UUC-DrM-00429
Ensembl Protein ID FBpp0075260
UniProt Accession Q9VUU5; Q9NGX7; KLHDB_DROME
Genbank Protein ID BAD06413.1; AAF43447.1; AAF49578.1; AAQ23590.1
Protein Name Kelch-like protein diablo
Genbank Nucleotide ID AB027612; AF237711; AE014296; BT010272
Gene Name dbo; CG6224
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0040230 FBtr0075505 FBpp0075260
FBgn0040230 FBtr0332133 FBpp0304443
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNAmiRecordsRAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 23487316
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.00e-23 81.6 72 138
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.10e-10 40.6 171 202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+vgg+++fah+++L+a+Ss+F a+f++elees+ + +v+i+d++  +++ l++F+Yt  +  +
   Q: 72   CDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELEESR-QTEVTIRDIDENAMELLIDFCYTAHIIVE 138
           9*************************************.***********************988765 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclgi++fAd+++c++L   a++f++++F+
   Q: 171  PTNCLGIRAFADTHSCRELLRIADKFTQHNFQ 202
           78*****************************6 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.
 Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth.
Protein Sequence
(Fasta)
MGDLPGSGST AQPRDAAVTG TGGNSTAGGG SSVGSTAVDR PPSPARLSHT SEKHPKVTLT 60
ELNMLRRHRE LCDVVLNVGG RKIFAHRVIL SACSSYFCAM FTGELEESRQ TEVTIRDIDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032170|E3,BTB_3-box|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTCACATCT CTATCGCCAT ACCAATCGTT TCGTGTTTCG ACTTTTCCAG GCCAACCAAA 60
AAACGATTTT TCCGTACTGA AAAGTGCAAT TCGCGCAAGG AAAATCTTCG ATGTGGTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032170|E3,BTB_3-box|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0003779--F:actin binding
GO:0042803--F:protein homodimerization activity
GO:0016049--P:cell growth
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0048812--P:neuron projection morphogenesis
GO:0016567--P:protein ubiquitination
GO:0050807--P:regulation of synapse organization
KEGG dme:Dmel_CG6224
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000721 Aegilops tauschii 34.06 3.00e-32 133.00
IUUC-Aml-001974 Ailuropoda melanoleuca 80.94 0.00e+00 961.00
IUUC-Apl-003481 Anas platyrhynchos 80.77 0.00e+00 960.00
IUUC-Aca-004877 Anolis carolinensis 80.59 0.00e+00 959.00
IUUC-Aly-005957 Arabidopsis lyrata 34.41 1.00e-39 156.00
IUUC-Ath-007066 Arabidopsis thaliana 34.44 3.00e-38 152.00
IUUC-Aor-010180 Aspergillus oryzae 26.53 5.00e-07 47.80
IUUC-Ame-011440 Astyanax mexicanus 80.77 0.00e+00 961.00
IUUC-Bta-012603 Bos taurus 80.94 0.00e+00 961.00
IUUC-Bra-016881 Brassica rapa 27.27 7.00e-17 81.60
IUUC-Cel-018464 Caenorhabditis elegans 60.97 0.00e+00 694.00
IUUC-Cja-019119 Callithrix jacchus 80.94 0.00e+00 961.00
IUUC-Cfa-020169 Canis familiaris 80.94 0.00e+00 961.00
IUUC-Cpo-021519 Cavia porcellus 80.94 0.00e+00 959.00
IUUC-Csa-024173 Chlorocebus sabaeus 80.94 0.00e+00 961.00
IUUC-Cho-024820 Choloepus hoffmanni 78.93 5.00e-180 623.00
IUUC-Cin-025270 Ciona intestinalis 72.77 0.00e+00 841.00
IUUC-Csv-026308 Ciona savignyi 73.04 0.00e+00 837.00
IUUC-Dre-027423 Danio rerio 80.77 0.00e+00 961.00
IUUC-Dno-029350 Dasypus novemcinctus 80.94 0.00e+00 958.00
IUUC-Dse-031294 Dothistroma septosporum 36.96 1.00e-04 38.10
IUUC-Ete-033187 Echinops telfairi 83.25 0.00e+00 665.00
IUUC-Eca-033751 Equus caballus 80.94 0.00e+00 959.00
IUUC-Eeu-034901 Erinaceus europaeus 80.59 0.00e+00 958.00
IUUC-Fca-035752 Felis catus 81.20 0.00e+00 869.00
IUUC-Fal-037630 Ficedula albicollis 80.74 0.00e+00 956.00
IUUC-Gmo-039481 Gadus morhua 80.77 0.00e+00 960.00
IUUC-Gga-040971 Gallus gallus 80.77 0.00e+00 960.00
IUUC-Gac-042602 Gasterosteus aculeatus 80.94 0.00e+00 961.00
IUUC-Ggo-044588 Gorilla gorilla 80.94 0.00e+00 960.00
IUUC-Hsa-046641 Homo sapiens 80.94 0.00e+00 961.00
IUUC-Itr-048394 Ictidomys tridecemlineatus 80.94 0.00e+00 961.00
IUUC-Lch-049968 Latimeria chalumnae 80.94 0.00e+00 961.00
IUUC-Loc-052720 Lepisosteus oculatus 80.77 0.00e+00 960.00
IUUC-Laf-054156 Loxodonta africana 80.94 0.00e+00 959.00
IUUC-Mcc-054629 Macaca mulatta 80.94 0.00e+00 961.00
IUUC-Meu-056605 Macropus eugenii 82.46 1.00e-133 469.00
IUUC-Mga-060014 Meleagris gallopavo 80.10 0.00e+00 943.00
IUUC-Mvi-060215 Microbotryum violaceum 30.14 7.00e-04 38.50
IUUC-Mmr-060814 Microcebus murinus 80.94 0.00e+00 962.00
IUUC-Mdo-062242 Monodelphis domestica 80.77 0.00e+00 959.00
IUUC-Mmu-064309 Mus musculus 80.94 0.00e+00 961.00
IUUC-Mpu-066587 Mustela putorius furo 80.94 0.00e+00 961.00
IUUC-Mlu-066958 Myotis lucifugus 80.77 0.00e+00 960.00
IUUC-Nle-069059 Nomascus leucogenys 79.37 0.00e+00 937.00
IUUC-Ont-072129 Oreochromis niloticus 80.94 0.00e+00 962.00
IUUC-Oan-073073 Ornithorhynchus anatinus 80.77 0.00e+00 960.00
IUUC-Ocu-073909 Oryctolagus cuniculus 80.07 0.00e+00 948.00
IUUC-Obr-076181 Oryza brachyantha 33.78 6.00e-36 145.00
IUUC-Ola-086392 Oryzias latipes 80.66 0.00e+00 958.00
IUUC-Olu-087696 Ostreococcus lucimarinus 33.33 1.00e-29 122.00
IUUC-Oga-088693 Otolemur garnettii 80.94 0.00e+00 961.00
IUUC-Oar-089905 Ovis aries 80.77 0.00e+00 958.00
IUUC-Ptr-091059 Pan troglodytes 80.94 0.00e+00 961.00
IUUC-Pan-091833 Papio anubis 77.97 0.00e+00 649.00
IUUC-Psi-093499 Pelodiscus sinensis 80.56 0.00e+00 955.00
IUUC-Pma-094404 Petromyzon marinus 72.16 0.00e+00 810.00
IUUC-Pfo-096891 Poecilia formosa 81.12 0.00e+00 964.00
IUUC-Pab-097715 Pongo abelii 76.92 0.00e+00 900.00
IUUC-Ppe-101154 Prunus persica 32.21 2.00e-38 153.00
IUUC-Pva-102944 Pteropus vampyrus 66.78 0.00e+00 783.00
IUUC-Rno-104878 Rattus norvegicus 80.94 0.00e+00 961.00
IUUC-Sha-107444 Sarcophilus harrisii 80.77 0.00e+00 960.00
IUUC-Ssc-115565 Sus scrofa 80.94 0.00e+00 960.00
IUUC-Tgu-116902 Taeniopygia guttata 80.77 0.00e+00 960.00
IUUC-Tru-118692 Takifugu rubripes 80.94 0.00e+00 962.00
IUUC-Tsy-119031 Tarsius syrichta 74.13 0.00e+00 850.00
IUUC-Tbe-127517 Tupaia belangeri 75.87 0.00e+00 885.00
IUUC-Ttr-128366 Tursiops truncatus 80.94 0.00e+00 961.00
IUUC-Vpa-130465 Vicugna pacos 80.77 0.00e+00 957.00
IUUC-Vvi-131673 Vitis vinifera 34.33 2.00e-44 172.00
IUUC-Xtr-132243 Xenopus tropicalis 80.49 0.00e+00 955.00
IUUC-Xma-133192 Xiphophorus maculatus 81.12 0.00e+00 964.00
Created Date 25-Jun-2017

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