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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064166
UUCD1 version UUC-MuM-01149
Ensembl Protein ID ENSMUSP00000075269.3
UniProt Accession Q69Z66; A2AJE3; B9EKJ6; Q3TPV7; Q8BRP5; Q8C4N1; MYSM1_MOUSE
Genbank Protein ID BAC31657.1; BAC38291.1; BAE37628.1; CAM14751.1; AAI50947.1; AAI51173.1; BAD32578.1
Protein Name Histone H2A deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1
Genbank Nucleotide ID AK043802; AK081684; AK164103; AL732611; BC150946; BC151172; AK173300
Gene Name Mysm1; Kiaa1915
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000062627.9 ENSMUST00000075872.3 ENSMUSP00000075269.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 79.14 0.00e+00 1241.00 IUUC-Hsa-046902
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
 Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
Protein Sequence
(Fasta)
MEAEEADVDV EGDVAAAAQP GNDESTASVF QDHYLDSTWR RENGCLPWTL DSTISDENRA 60
IIEKMLLEEE YYLSNKSLPG KFWVNQKEDN KKYTNSLQKS SKAMVDSPAK PASHSVKWTV 120
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Protein Fasta Sequence


>IUUC-Mmu-064166|DUB,JAMM|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGATCTCGC GAGTACGCCT GCGTCAGGTG CAGTCATGGA GGCGGAGGAG GCGGATGTGG 60
ATGTGGAAGG AGATGTTGCG GCGGCTGCAC AGCCGGGGTG AGGCGCGGAG CGGGGTCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064166|DUB,JAMM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR009057--Homeobox-like
IPR000555--JAMM/MPN+_dom
IPR017930--Myb_dom
IPR033497--MYSM1
IPR001005--SANT/Myb
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50934--SWIRM
Pfam

PF01398--JAB
PF00249--Myb_DNA-binding
PF04433--SWIRM
SMART

SM00232--JAB_MPN
SM00717--SANT
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0032403--F:protein complex binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0006338--P:chromatin remodeling
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0043473--P:pigmentation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0051797--P:regulation of hair follicle development
GO:0006351--P:transcription, DNA-templated
KEGG mmu:320713
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001270 Ailuropoda melanoleuca 80.17 0.00e+00 1281.00
IUUC-Apl-003363 Anas platyrhynchos 70.09 0.00e+00 991.00
IUUC-Aca-005139 Anolis carolinensis 66.83 0.00e+00 1033.00
IUUC-Ame-011693 Astyanax mexicanus 54.01 0.00e+00 690.00
IUUC-Bta-013079 Bos taurus 78.94 0.00e+00 1220.00
IUUC-Cja-019242 Callithrix jacchus 78.07 0.00e+00 1212.00
IUUC-Cfa-020562 Canis familiaris 78.47 0.00e+00 1198.00
IUUC-Cpo-021656 Cavia porcellus 75.15 0.00e+00 1149.00
IUUC-Cre-022774 Chlamydomonas reinhardtii 30.22 1.00e-15 78.20
IUUC-Csa-023482 Chlorocebus sabaeus 78.65 0.00e+00 1220.00
IUUC-Cho-024724 Choloepus hoffmanni 74.23 5.00e-75 276.00
IUUC-Cme-027237 Cyanidioschyzon merolae 40.51 5.00e-30 125.00
IUUC-Dre-028234 Danio rerio 68.43 6.00e-172 597.00
IUUC-Dno-029985 Dasypus novemcinctus 73.95 0.00e+00 1045.00
IUUC-Dor-030957 Dipodomys ordii 71.77 0.00e+00 1041.00
IUUC-Ete-032831 Echinops telfairi 70.17 0.00e+00 1022.00
IUUC-Eca-033285 Equus caballus 77.70 0.00e+00 1211.00
IUUC-Eeu-035164 Erinaceus europaeus 65.25 0.00e+00 899.00
IUUC-Fca-036480 Felis catus 77.78 0.00e+00 1170.00
IUUC-Fal-037081 Ficedula albicollis 66.46 0.00e+00 947.00
IUUC-Gmo-039445 Gadus morhua 62.73 1.00e-161 563.00
IUUC-Gga-040639 Gallus gallus 69.82 0.00e+00 1027.00
IUUC-Gac-042370 Gasterosteus aculeatus 64.11 3.00e-153 535.00
IUUC-Ggo-044894 Gorilla gorilla 79.16 0.00e+00 1230.00
IUUC-Hsa-046902 Homo sapiens 79.04 0.00e+00 1228.00
IUUC-Itr-047908 Ictidomys tridecemlineatus 80.53 0.00e+00 1083.00
IUUC-Lch-049854 Latimeria chalumnae 57.60 0.00e+00 863.00
IUUC-Loc-052310 Lepisosteus oculatus 69.93 0.00e+00 634.00
IUUC-Laf-053369 Loxodonta africana 78.14 0.00e+00 1219.00
IUUC-Mcc-055385 Macaca mulatta 78.92 0.00e+00 1218.00
IUUC-Meu-056008 Macropus eugenii 60.17 0.00e+00 849.00
IUUC-Mga-059526 Meleagris gallopavo 65.65 0.00e+00 931.00
IUUC-Mmr-060949 Microcebus murinus 80.24 0.00e+00 1269.00
IUUC-Mdo-061821 Monodelphis domestica 71.58 0.00e+00 1112.00
IUUC-Mpu-065701 Mustela putorius furo 79.01 0.00e+00 1258.00
IUUC-Mlu-067089 Myotis lucifugus 78.76 0.00e+00 1248.00
IUUC-Nle-069917 Nomascus leucogenys 78.46 0.00e+00 1219.00
IUUC-Opr-070449 Ochotona princeps 70.07 0.00e+00 757.00
IUUC-Ont-071468 Oreochromis niloticus 65.64 1.00e-158 553.00
IUUC-Ocu-073867 Oryctolagus cuniculus 74.20 0.00e+00 679.00
IUUC-Ola-087430 Oryzias latipes 47.40 1.00e-171 597.00
IUUC-Olu-087581 Ostreococcus lucimarinus 35.83 1.00e-30 127.00
IUUC-Oga-088967 Otolemur garnettii 78.43 0.00e+00 1196.00
IUUC-Oar-089773 Ovis aries 78.70 0.00e+00 1215.00
IUUC-Ptr-091260 Pan troglodytes 79.04 0.00e+00 1229.00
IUUC-Pan-092564 Papio anubis 78.67 0.00e+00 1213.00
IUUC-Psi-094097 Pelodiscus sinensis 70.56 0.00e+00 944.00
IUUC-Pma-094538 Petromyzon marinus 66.33 1.00e-37 150.00
IUUC-Pfo-097392 Poecilia formosa 49.02 0.00e+00 696.00
IUUC-Pab-098496 Pongo abelii 78.22 0.00e+00 1212.00
IUUC-Pca-100438 Procavia capensis 61.42 1.00e-104 374.00
IUUC-Pva-103082 Pteropus vampyrus 78.97 0.00e+00 1240.00
IUUC-Rno-105976 Rattus norvegicus 89.79 0.00e+00 1394.00
IUUC-Sha-106498 Sarcophilus harrisii 67.08 0.00e+00 990.00
IUUC-Sar-113274 Sorex araneus 71.76 0.00e+00 1062.00
IUUC-Sre-115088 Sporisorium reilianum 34.09 1.00e-08 56.20
IUUC-Ssc-115653 Sus scrofa 77.60 0.00e+00 1218.00
IUUC-Tgu-117140 Taeniopygia guttata 66.46 0.00e+00 959.00
IUUC-Tru-117818 Takifugu rubripes 64.07 4.00e-151 528.00
IUUC-Tsy-118897 Tarsius syrichta 75.06 0.00e+00 1121.00
IUUC-Tni-119769 Tetraodon nigroviridis 50.51 0.00e+00 676.00
IUUC-Tbe-127944 Tupaia belangeri 88.24 0.00e+00 755.00
IUUC-Ttr-129252 Tursiops truncatus 89.88 0.00e+00 738.00
IUUC-Vpa-130289 Vicugna pacos 78.60 0.00e+00 1162.00
IUUC-Xtr-131964 Xenopus tropicalis 56.44 0.00e+00 822.00
Created Date 25-Jun-2017

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