iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001201

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01040184

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000018371.1	ENSAMET00000020180.1	ENSAMEP00000019411.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-135	449.6	989	1318

Active Site

Position(s)	Description	Evidence
1288	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 989  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1075
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1076 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKIGGSEIVVTNKNKKEYIYLV 1157
           ***********************************99...6666..79*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++
   Q: 1158 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRL 1244
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1245 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1318
           *************************************************************************8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ESSGDDLESN VPMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIQENVKSQE RSSVLSPENV NKKSSCLQIS LQPTRYSGCL QSSHVLADGE DASFMCVLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA TCCTCTGTCA 60
GAAAGCTCCG GAGATGATTT GGAGAGCAAT GTTCCCATGT GCTTCAAAAG ACCAACCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003886	Anas platyrhynchos	75.72	0.00e+00	1269.00
IUUC-Ame-011138	Astyanax mexicanus	83.96	0.00e+00	854.00
IUUC-Bgr-012148	Blumeria graminis	46.86	5.00e-155	541.00
IUUC-Bta-012453	Bos taurus	90.07	0.00e+00	2300.00
IUUC-Bci-013785	Botrytis cinerea	47.36	2.00e-157	550.00
IUUC-Cja-019034	Callithrix jacchus	93.77	0.00e+00	1416.00
IUUC-Cfa-020258	Canis familiaris	94.10	0.00e+00	2377.00
IUUC-Cpo-021648	Cavia porcellus	89.79	0.00e+00	1463.00
IUUC-Csa-023334	Chlorocebus sabaeus	95.14	0.00e+00	1505.00
IUUC-Cho-024672	Choloepus hoffmanni	81.73	0.00e+00	696.00
IUUC-Cin-025157	Ciona intestinalis	56.42	0.00e+00	884.00
IUUC-Csv-026098	Ciona savignyi	58.08	0.00e+00	656.00
IUUC-Dno-029159	Dasypus novemcinctus	89.81	0.00e+00	1333.00
IUUC-Dor-030729	Dipodomys ordii	79.11	0.00e+00	1053.00
IUUC-Dme-032166	Drosophila melanogaster	67.99	0.00e+00	716.00
IUUC-Ete-032409	Echinops telfairi	85.95	0.00e+00	1196.00
IUUC-Eca-033441	Equus caballus	95.15	0.00e+00	1462.00
IUUC-Eeu-034546	Erinaceus europaeus	78.06	0.00e+00	1190.00
IUUC-Fca-036384	Felis catus	94.42	0.00e+00	2439.00
IUUC-Fal-037547	Ficedula albicollis	80.40	0.00e+00	1311.00
IUUC-Gga-040524	Gallus gallus	81.89	0.00e+00	1314.00
IUUC-Gac-042607	Gasterosteus aculeatus	67.64	0.00e+00	1110.00
IUUC-Hsa-046479	Homo sapiens	91.31	0.00e+00	2355.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.00	0.00e+00	1218.00
IUUC-Lch-050445	Latimeria chalumnae	59.94	0.00e+00	1483.00
IUUC-Loc-052645	Lepisosteus oculatus	73.34	0.00e+00	1198.00
IUUC-Lma-052980	Leptosphaeria maculans	44.33	2.00e-89	322.00
IUUC-Laf-053638	Loxodonta africana	83.94	0.00e+00	1360.00
IUUC-Mcc-055585	Macaca mulatta	91.08	0.00e+00	2322.00
IUUC-Meu-056897	Macropus eugenii	95.47	2.00e-171	596.00
IUUC-Mga-059362	Meleagris gallopavo	75.89	0.00e+00	1284.00
IUUC-Mvi-060395	Microbotryum violaceum	53.58	4.00e-150	525.00
IUUC-Mmr-061061	Microcebus murinus	91.09	0.00e+00	2353.00
IUUC-Mmu-063318	Mus musculus	79.58	0.00e+00	1273.00
IUUC-Mpu-066567	Mustela putorius furo	96.90	0.00e+00	1582.00
IUUC-Mlu-068148	Myotis lucifugus	89.12	0.00e+00	2292.00
IUUC-Nle-069225	Nomascus leucogenys	90.93	0.00e+00	2343.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.34	0.00e+00	1383.00
IUUC-Ocu-074409	Oryctolagus cuniculus	86.72	0.00e+00	2207.00
IUUC-Oga-088241	Otolemur garnettii	85.97	0.00e+00	2113.00
IUUC-Oar-089797	Ovis aries	94.53	0.00e+00	1524.00
IUUC-Ptr-091629	Pan troglodytes	94.44	0.00e+00	1392.00
IUUC-Psi-093618	Pelodiscus sinensis	68.08	0.00e+00	1637.00
IUUC-Pab-098394	Pongo abelii	95.27	0.00e+00	1524.00
IUUC-Pca-100568	Procavia capensis	78.04	0.00e+00	1156.00
IUUC-Pva-102303	Pteropus vampyrus	90.59	0.00e+00	1090.00
IUUC-Rno-106095	Rattus norvegicus	79.20	0.00e+00	1271.00
IUUC-Sha-107370	Sarcophilus harrisii	67.40	0.00e+00	1752.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.54	2.00e-158	552.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.61	4.00e-158	551.00
IUUC-Sre-114929	Sporisorium reilianum	47.46	3.00e-155	542.00
IUUC-Tgu-117474	Taeniopygia guttata	81.14	0.00e+00	1324.00
IUUC-Tru-117675	Takifugu rubripes	65.55	0.00e+00	1076.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.77	0.00e+00	1068.00
IUUC-Tre-122203	Trichoderma reesei	46.64	2.00e-153	535.00
IUUC-Tbe-127408	Tupaia belangeri	86.83	0.00e+00	1163.00
IUUC-Ttr-128437	Tursiops truncatus	86.70	0.00e+00	1215.00
IUUC-Uma-129332	Ustilago maydis	47.63	2.00e-148	519.00
IUUC-Vpa-130503	Vicugna pacos	88.74	0.00e+00	1302.00
IUUC-Xtr-132431	Xenopus tropicalis	70.51	0.00e+00	1197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence