iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132061

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01128444

Gene Name

usp44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009237.3	ENSXETT00000020288.3	ENSXETP00000020288.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-85	287.3	277	652

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNS+LQ Ls+++ +re++l+   +   +++   +                                            
   Q: 277  TGLRNLGNTCYMNSILQILSHLHVFRECFLQldlN---QTQ---Ellaaagsgktrlsskyppsavlpkvtqkhtkvqrslarrqsfss 359
           7******************************4331...333...33346778888999999999************************* PP
   S: 43   ....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkek 111
                               ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el    
   Q: 360  glsggasnsrnmeliqpkepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL---- 444
           *************999999999999************************************************************.... PP
   S: 112  nkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLe 192
                e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cd++s++ epf+dlsl++p++ + + +         l+++L+
   Q: 445  -----ETTGTRYPTLIPASQRKLIKQVLNIVNNIFHGQLLSQVTCLACDHKSNTIEPFWDLSLEFPERYHFNGKetasqrpcLLTEMLA 528
           .....67788888899999***********************************************7776555577777888******* PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f ++L+++p+c+++++
   Q: 529  KFTETEALEGKI-YACDQCNTKRRkfsskpvvlteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVRFDQMLNMEPYCCREST 615
           *********965.*******999999999999999***********************997.8889********************888 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekg 304
           +  +  + +Y+L++vv+H+G +++sGHY+a+++n +g
   Q: 616  AALRadCFIYDLSSVVMHHGkGFGSGHYTAFCYNPEG 652
           776577***************************9776 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

KLKMDKCKHV GRLRLAQDHS ILNPQKWHCV DCNTTESVWA CLSCSHVACG RYIEEHALRH 60
FQDSKHPLAL EVNELYVFCY LCDDYVLNDN TTGDLKLLRS TLSAIKSQNY DCTTRSGRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTATTGTTG TCCCTGCACC GCTTCTCCCT GACCGGGGAA CAAGCGCAGC AAGCGACAAG 60
TCTGCGCGGT GAGTGCCTGA TTAAACAGCA TCTGGTCAGA CAGTAGCGAC TTGTTCGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	72.60	0.00e+00	947.00
IUUC-Apl-003673	Anas platyrhynchos	82.11	0.00e+00	1035.00
IUUC-Aca-004434	Anolis carolinensis	80.34	0.00e+00	1026.00
IUUC-Ame-010986	Astyanax mexicanus	67.56	0.00e+00	858.00
IUUC-Bta-012774	Bos taurus	72.17	0.00e+00	938.00
IUUC-Cja-019619	Callithrix jacchus	71.54	0.00e+00	925.00
IUUC-Cfa-020957	Canis familiaris	72.21	0.00e+00	956.00
IUUC-Csa-023177	Chlorocebus sabaeus	71.39	0.00e+00	931.00
IUUC-Cho-024877	Choloepus hoffmanni	68.18	0.00e+00	633.00
IUUC-Dre-027878	Danio rerio	69.20	0.00e+00	830.00
IUUC-Dno-029832	Dasypus novemcinctus	72.41	0.00e+00	961.00
IUUC-Ete-032627	Echinops telfairi	70.78	0.00e+00	929.00
IUUC-Eca-033863	Equus caballus	70.35	0.00e+00	920.00
IUUC-Eeu-035225	Erinaceus europaeus	67.99	0.00e+00	868.00
IUUC-Fca-036288	Felis catus	72.87	0.00e+00	948.00
IUUC-Fal-037207	Ficedula albicollis	79.72	0.00e+00	995.00
IUUC-Gga-040457	Gallus gallus	80.52	0.00e+00	994.00
IUUC-Ggo-044926	Gorilla gorilla	72.15	0.00e+00	933.00
IUUC-Hsa-046079	Homo sapiens	72.45	0.00e+00	937.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	72.19	0.00e+00	945.00
IUUC-Lch-050260	Latimeria chalumnae	73.29	0.00e+00	915.00
IUUC-Loc-051981	Lepisosteus oculatus	79.65	0.00e+00	647.00
IUUC-Laf-054491	Loxodonta africana	71.63	0.00e+00	927.00
IUUC-Mcc-055694	Macaca mulatta	70.93	0.00e+00	925.00
IUUC-Mga-059523	Meleagris gallopavo	80.12	0.00e+00	1009.00
IUUC-Mmr-060885	Microcebus murinus	73.06	0.00e+00	964.00
IUUC-Mdo-063018	Monodelphis domestica	80.25	0.00e+00	1004.00
IUUC-Mmu-064012	Mus musculus	65.65	0.00e+00	838.00
IUUC-Mpu-066207	Mustela putorius furo	71.91	0.00e+00	955.00
IUUC-Mlu-066929	Myotis lucifugus	69.59	0.00e+00	926.00
IUUC-Opr-070375	Ochotona princeps	66.62	0.00e+00	852.00
IUUC-Ont-071637	Oreochromis niloticus	69.62	0.00e+00	854.00
IUUC-Oan-073030	Ornithorhynchus anatinus	79.07	0.00e+00	859.00
IUUC-Ocu-074836	Oryctolagus cuniculus	71.30	0.00e+00	911.00
IUUC-Oga-088367	Otolemur garnettii	72.80	0.00e+00	941.00
IUUC-Oar-089953	Ovis aries	71.41	0.00e+00	953.00
IUUC-Ptr-090980	Pan troglodytes	72.15	0.00e+00	933.00
IUUC-Pan-092748	Papio anubis	71.65	0.00e+00	933.00
IUUC-Psi-094078	Pelodiscus sinensis	81.55	0.00e+00	891.00
IUUC-Pma-094155	Petromyzon marinus	58.25	1.00e-86	312.00
IUUC-Pab-098514	Pongo abelii	72.30	0.00e+00	933.00
IUUC-Pva-102984	Pteropus vampyrus	70.64	0.00e+00	957.00
IUUC-Rno-106019	Rattus norvegicus	65.55	0.00e+00	868.00
IUUC-Sha-106965	Sarcophilus harrisii	79.73	0.00e+00	999.00
IUUC-Ssc-115299	Sus scrofa	72.02	0.00e+00	957.00
IUUC-Tgu-117160	Taeniopygia guttata	79.14	0.00e+00	1003.00
IUUC-Tru-118156	Takifugu rubripes	66.97	0.00e+00	832.00
IUUC-Tni-119733	Tetraodon nigroviridis	65.87	0.00e+00	850.00
IUUC-Tbe-128084	Tupaia belangeri	69.51	0.00e+00	930.00
IUUC-Ttr-128928	Tursiops truncatus	71.87	0.00e+00	963.00
IUUC-Vpa-130706	Vicugna pacos	72.48	0.00e+00	965.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence