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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018135
UUCD1 version UUC-CaE-00045
Ensembl Protein ID K04A8.6b
UniProt Accession Q94251; DRE1_CAEEL
Genbank Protein ID CCD68857.1
Protein Name F-box protein dre-1; Daf-12 redundant function protein
Genbank Nucleotide ID FO081056
Gene Name dre-1; K04A8.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00001089 K04A8.6b K04A8.6b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDPINAMentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 17336909
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 3.40e-05 24.2 236 292
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 91   tptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktvt 147
             + ee+ ++++++rlpee+l++++++l+ ++ll++++v+ r++++++++++wk+++
   Q: 236  EEAVEEEDQQDHINRLPEELLLKVFSFLPDKSLLACSSVSYRFNQISNSHEVWKELY 292
           556799999***************************************9****9875 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1 (PubMed:17336909, PubMed:23431138, PubMed:24613396, PubMed:24968003). Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation (PubMed:17336909). Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9 (PubMed:23431138).
 Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1 (PubMed:17336909, PubMed:23431138, PubMed:24613396, PubMed:24968003). Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation (PubMed:17336909). Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9 (PubMed:23431138).
Protein Sequence
(Fasta)
MAEEEEVSSD DVLMESRPSL VSTRAAHLSP KLQRRGSSSA RKFAIRNLPP STQRVTRRST 60
RRGSSTASTS CVPAFEGPTS SLVGQEMSSS SSPFFHPPPQ QVMDDTTQQS PSYSQNSNSP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018135|E3,F-box|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCGGAGG AAGAAGAAGT GTCGAGTGAC GATGTGCTTA TGGAATCGCG GCCTTCTCTC 60
GTTTCAACGA GAGCCGCGCA TCTTTCTCCA AAACTTCAGA GAAGAGGATC CTCATCTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018135|E3,F-box|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR029799--FBX11/DRE-1
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
IPR003126--Znf_UBR
PROSITE

PS50181--FBOX
PS51157--ZF_UBR
Pfam

PF12937--F-box-like
PF02207--zf-UBR
SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1
SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0008406--P:gonad development
GO:0008078--P:mesodermal cell migration
GO:0018996--P:molting cycle, collagen and cuticulin-based cuticle
GO:0002119--P:nematode larval development
GO:0043065--P:positive regulation of apoptotic process
GO:0016567--P:protein ubiquitination
GO:0040034--P:regulation of development, heterochronic
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002291 Ailuropoda melanoleuca 59.03 0.00e+00 949.00
IUUC-Apl-003412 Anas platyrhynchos 59.05 0.00e+00 949.00
IUUC-Aca-004842 Anolis carolinensis 59.05 0.00e+00 948.00
IUUC-Ame-011539 Astyanax mexicanus 59.18 0.00e+00 951.00
IUUC-Bgr-012114 Blumeria graminis 32.00 5.00e-04 39.30
IUUC-Bta-013526 Bos taurus 55.42 2.00e-179 621.00
IUUC-Bci-013711 Botrytis cinerea 36.51 1.00e-07 50.10
IUUC-Cja-019156 Callithrix jacchus 59.18 0.00e+00 952.00
IUUC-Cfa-020503 Canis familiaris 59.18 0.00e+00 953.00
IUUC-Cpo-022148 Cavia porcellus 59.18 0.00e+00 953.00
IUUC-Cre-022959 Chlamydomonas reinhardtii 20.87 3.00e-08 52.40
IUUC-Csa-023799 Chlorocebus sabaeus 59.18 0.00e+00 952.00
IUUC-Cho-024925 Choloepus hoffmanni 59.32 0.00e+00 869.00
IUUC-Cin-025649 Ciona intestinalis 56.72 0.00e+00 905.00
IUUC-Csv-026010 Ciona savignyi 57.03 0.00e+00 879.00
IUUC-Cgl-026674 Colletotrichum gloeosporioides 30.88 4.00e-05 42.00
IUUC-Dre-027855 Danio rerio 59.18 0.00e+00 952.00
IUUC-Dno-029555 Dasypus novemcinctus 58.90 0.00e+00 942.00
IUUC-Dor-030610 Dipodomys ordii 55.27 0.00e+00 811.00
IUUC-Dse-031519 Dothistroma septosporum 36.36 6.00e-04 38.10
IUUC-Dme-031852 Drosophila melanogaster 56.57 0.00e+00 907.00
IUUC-Ete-032999 Echinops telfairi 57.00 0.00e+00 896.00
IUUC-Eca-033942 Equus caballus 59.18 0.00e+00 953.00
IUUC-Eeu-034872 Erinaceus europaeus 59.05 0.00e+00 948.00
IUUC-Fca-035904 Felis catus 57.87 0.00e+00 921.00
IUUC-Fal-036742 Ficedula albicollis 59.05 0.00e+00 949.00
IUUC-Gmo-039082 Gadus morhua 58.54 0.00e+00 941.00
IUUC-Ggr-039881 Gaeumannomyces graminis 26.79 1.00e-05 43.90
IUUC-Gga-040292 Gallus gallus 59.05 0.00e+00 949.00
IUUC-Gac-042106 Gasterosteus aculeatus 59.05 0.00e+00 946.00
IUUC-Ggo-045283 Gorilla gorilla 59.18 0.00e+00 952.00
IUUC-Hsa-046244 Homo sapiens 59.18 0.00e+00 952.00
IUUC-Itr-047990 Ictidomys tridecemlineatus 59.18 0.00e+00 953.00
IUUC-Lch-049831 Latimeria chalumnae 59.05 0.00e+00 947.00
IUUC-Loc-051875 Lepisosteus oculatus 59.05 0.00e+00 950.00
IUUC-Lma-053148 Leptosphaeria maculans 28.57 7.00e-04 37.70
IUUC-Laf-053642 Loxodonta africana 59.18 0.00e+00 950.00
IUUC-Mcc-055761 Macaca mulatta 59.18 0.00e+00 953.00
IUUC-Meu-056886 Macropus eugenii 53.63 1.00e-161 562.00
IUUC-Mga-059470 Meleagris gallopavo 59.05 0.00e+00 949.00
IUUC-Mmr-060959 Microcebus murinus 59.18 0.00e+00 953.00
IUUC-Mdo-062165 Monodelphis domestica 59.18 0.00e+00 953.00
IUUC-Mmu-063590 Mus musculus 59.18 0.00e+00 953.00
IUUC-Mpu-066702 Mustela putorius furo 59.18 0.00e+00 954.00
IUUC-Mlu-067906 Myotis lucifugus 58.88 0.00e+00 944.00
IUUC-Nle-069878 Nomascus leucogenys 59.18 0.00e+00 952.00
IUUC-Opr-070211 Ochotona princeps 63.33 8.00e-67 247.00
IUUC-Ont-072251 Oreochromis niloticus 59.05 0.00e+00 949.00
IUUC-Oan-073077 Ornithorhynchus anatinus 52.85 0.00e+00 644.00
IUUC-Ocu-074419 Oryctolagus cuniculus 59.05 0.00e+00 948.00
IUUC-Osa-086065 Oryza sativa 34.88 1.00e-05 42.70
IUUC-Ola-087171 Oryzias latipes 59.15 0.00e+00 947.00
IUUC-Oga-088010 Otolemur garnettii 59.18 0.00e+00 949.00
IUUC-Oar-089660 Ovis aries 59.18 0.00e+00 954.00
IUUC-Ptr-091220 Pan troglodytes 59.18 0.00e+00 953.00
IUUC-Pan-092606 Papio anubis 64.02 0.00e+00 877.00
IUUC-Psi-093950 Pelodiscus sinensis 59.05 0.00e+00 950.00
IUUC-Pma-094248 Petromyzon marinus 57.42 0.00e+00 936.00
IUUC-Pfo-097361 Poecilia formosa 59.31 0.00e+00 948.00
IUUC-Pab-097736 Pongo abelii 59.18 0.00e+00 952.00
IUUC-Pca-100204 Procavia capensis 54.03 0.00e+00 826.00
IUUC-Pva-102248 Pteropus vampyrus 54.80 0.00e+00 698.00
IUUC-Pgr-103283 Puccinia graminis 40.00 1.00e-06 46.60
IUUC-Ptt-103902 Puccinia triticina 33.33 1.00e-03 37.70
IUUC-Pte-104054 Pyrenophora teres 33.64 4.00e-09 55.10
IUUC-Pyt-104462 Pyrenophora triticirepentis 33.64 3.00e-09 55.10
IUUC-Rno-106009 Rattus norvegicus 59.18 0.00e+00 953.00
IUUC-Sce-106294 Saccharomyces cerevisiae 29.25 1.00e-04 40.80
IUUC-Sha-107330 Sarcophilus harrisii 59.18 0.00e+00 953.00
IUUC-Stu-112725 Solanum tuberosum 28.12 2.00e-06 45.80
IUUC-Sar-112927 Sorex araneus 72.84 3.00e-148 517.00
IUUC-Ssc-115330 Sus scrofa 58.95 0.00e+00 943.00
IUUC-Tgu-116883 Taeniopygia guttata 59.05 0.00e+00 949.00
IUUC-Tru-118021 Takifugu rubripes 59.03 0.00e+00 947.00
IUUC-Tsy-119194 Tarsius syrichta 58.90 0.00e+00 759.00
IUUC-Tni-119690 Tetraodon nigroviridis 59.08 0.00e+00 940.00
IUUC-Tae-123166 Triticum aestivum 34.88 3.00e-05 41.60
IUUC-Tme-127013 Tuber melanosporum 35.29 1.00e-08 53.50
IUUC-Tbe-127560 Tupaia belangeri 62.18 8.00e-96 343.00
IUUC-Ttr-129186 Tursiops truncatus 56.23 0.00e+00 894.00
IUUC-Vda-129883 Verticillium dahliae 27.06 1.00e-04 40.80
IUUC-Vpa-130098 Vicugna pacos 57.51 0.00e+00 910.00
IUUC-Xtr-132162 Xenopus tropicalis 59.05 0.00e+00 948.00
Created Date 25-Jun-2017

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